SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rjw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 149
VAL A 286
TRP A  87
 None
ETF  A 501 ( 4.8A)
ETF  A 501 (-3.7A)
 0.95A 1c4dC-1rjwA:
undetectable
1c4dD-1rjwA:
undetectable		 1c4dC-1rjwA:
4.00
1c4dD-1rjwA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 ALA A 156
GLY A 177
THR A 237
ILE A 170
 None
 0.74A 1gtnI-1rjwA:
undetectable
1gtnJ-1rjwA:
undetectable		 1gtnI-1rjwA:
12.39
1gtnJ-1rjwA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A  36
ALA A 144
ILE A 134
GLY A  84
ILE A  85
VAL A 151
 None
 1.29A 1muiB-1rjwA:
undetectable		 1muiB-1rjwA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 CYH A  38
ARG A 331
CYH A 148
 ZN  A 402 (-2.2A)
None
ZN  A 402 (-2.4A)
 1.50A 1p9gA-1rjwA:
undetectable		 1p9gA-1rjwA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 LEU A 336
ALA A   4
ILE A  58
GLY A  60
PHE A 320
 None
 1.35A 1sv9A-1rjwA:
undetectable		 1sv9A-1rjwA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 149
VAL A 286
TRP A  87
 None
ETF  A 501 ( 4.8A)
ETF  A 501 (-3.7A)
 0.91A 1tkqB-1rjwA:
undetectable		 1tkqB-1rjwA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 7 CYH A  98
TYR A  97
CYH A  92
HIS A 108
 ZN  A 401 ( 2.3A)
None
ZN  A 401 ( 2.2A)
None
 1.29A 1yvmA-1rjwA:
undetectable		 1yvmA-1rjwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  64
GLY A  65
LEU A 296
LEU A 138
ALA A 143
 None
 0.77A 2egvA-1rjwA:
2.9		 2egvA-1rjwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  64
GLY A  65
LEU A 296
LEU A 138
ALA A 143
 None
 0.80A 2egvB-1rjwA:
2.7		 2egvB-1rjwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 11 GLY A  36
ILE A  58
GLY A 113
VAL A  30
ILE A  32
 None
 0.88A 2fxeB-1rjwA:
undetectable		 2fxeB-1rjwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A  36
ALA A 144
ILE A 134
GLY A  84
ILE A  85
VAL A 151
 None
 1.45A 2q5kB-1rjwA:
undetectable		 2q5kB-1rjwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 THR A 104
VAL A 151
THR A 152
VAL A 159
 None
 0.97A 2qbmA-1rjwA:
undetectable		 2qbmA-1rjwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A  36
ALA A 144
ILE A 134
GLY A  84
ILE A  85
VAL A 151
 None
 1.41A 2r5pD-1rjwA:
undetectable		 2r5pD-1rjwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 8 HIS A  61
ASP A  41
ARG A 331
ALA A 149
 ZN  A 402 (-3.2A)
None
None
None
 1.32A 2rk8A-1rjwA:
undetectable		 2rk8A-1rjwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A  64
GLY A  65
LEU A 296
LEU A 138
ALA A 143
 None
 0.96A 2v3kA-1rjwA:
undetectable		 2v3kA-1rjwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 9 ILE A  85
ALA A 128
VAL A 131
LYS A 133
 None
 0.96A 2vufB-1rjwA:
undetectable		 2vufB-1rjwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A  64
GLY A  65
LEU A 296
LEU A 138
ALA A 143
 None
 0.84A 2z0yB-1rjwA:
undetectable		 2z0yB-1rjwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A 119
GLY A 113
GLY A  60
 None
 0.41A 3bogC-1rjwA:
undetectable		 3bogC-1rjwA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  36
ILE A  58
GLY A 113
VAL A  30
ILE A  32
 None
 0.83A 3d1xA-1rjwA:
undetectable		 3d1xA-1rjwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A  62
VAL A  37
CYH A  38
 None
None
ZN  A 402 (-2.2A)
 1.07A 3fbxA-1rjwA:
undetectable		 3fbxA-1rjwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  84
GLU A  62
ALA A 149
ASP A  41
ARG A 331
 None
 1.27A 3jzjA-1rjwA:
undetectable		 3jzjA-1rjwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 11 ALA A 143
ILE A 146
SER A 139
LEU A 138
ALA A 299
 None
 1.24A 3kw2B-1rjwA:
2.3		 3kw2B-1rjwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  36
ILE A  58
GLY A 113
VAL A  30
ILE A  32
 None
 0.90A 3ndtB-1rjwA:
undetectable		 3ndtB-1rjwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 GLY A  36
ALA A 144
ILE A 134
GLY A  84
ILE A  85
VAL A 151
 None
 1.33A 3tl9B-1rjwA:
undetectable		 3tl9B-1rjwA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 306
GLY A 177
GLY A 175
GLY A 330
ALA A 180
 None
 0.99A 4uciA-1rjwA:
3.7		 4uciA-1rjwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 306
GLY A 177
GLY A 175
GLY A 330
ALA A 180
 None
 1.00A 4uciB-1rjwA:
3.6		 4uciB-1rjwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 8 GLY A  84
VAL A  64
ALA A  34
LEU A 336
GLY A  60
 None
 1.28A 4zauA-1rjwA:
undetectable		 4zauA-1rjwA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 203
GLY A 208
ALA A 209
ASP A 210
ILE A 170
VAL A 168
 None
 1.49A 5e5kA-1rjwA:
undetectable		 5e5kA-1rjwA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A  16
LEU A 336
ILE A 316
 None
 0.68A 5kc0A-1rjwA:
undetectable		 5kc0A-1rjwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  36
ILE A  58
GLY A 113
VAL A  30
ILE A  32
 None
 0.84A 5kqxA-1rjwA:
undetectable		 5kqxA-1rjwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		4 / 5 THR A  40
HIS A  43
ALA A  44
ASP A  41
 ETF  A 501 ( 3.3A)
None
None
None
 1.26A 5mfxA-1rjwA:
3.1		 5mfxA-1rjwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A  28
GLY A  71
ASP A 129
ALA A 128
LEU A  77
 None
 1.24A 5x6yC-1rjwA:
2.4		 5x6yC-1rjwA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 SER A 284
GLY A 283
LEU A 262
GLY A 261
LEU A  13
 None
None
ETF  A 501 (-4.7A)
None
None
 1.45A 6hqbA-1rjwA:
undetectable
6hqbJ-1rjwA:
undetectable		 6hqbA-1rjwA:
12.87
6hqbJ-1rjwA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1rjw ALCOHOL
DEHYDROGENASE
(Geobacillus
stearothermophil
us) 		5 / 10 TRP A  49
SER A 284
GLY A 283
LEU A 262
GLY A 261
 None
None
None
ETF  A 501 (-4.7A)
None
 1.43A 6hqbA-1rjwA:
undetectable
6hqbJ-1rjwA:
undetectable		 6hqbA-1rjwA:
12.87
6hqbJ-1rjwA:
7.67