SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1rkb PROTEIN AD-004
(Homo
sapiens) 		4 / 7 ARG A  70
ASP A  63
ASP A  59
ARG A  87
 None
None
LI  A 303 ( 4.6A)
None
 1.49A 1cebA-1rkbA:
undetectable		 1cebA-1rkbA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1rkb PROTEIN AD-004
(Homo
sapiens) 		4 / 8 VAL A  34
TYR A  78
ASP A  82
LEU A  65
 None
 1.24A 1pk2A-1rkbA:
undetectable		 1pk2A-1rkbA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1rkb PROTEIN AD-004
(Homo
sapiens) 		5 / 12 PRO A  12
LYS A  16
ASN A  33
GLY A  35
ARG A  39
 SO4  A 201 (-4.6A)
SO4  A 201 (-2.7A)
None
None
None
 0.96A 2axnA-1rkbA:
9.3		 2axnA-1rkbA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1rkb PROTEIN AD-004
(Homo
sapiens) 		5 / 12 PRO A  12
LYS A  16
THR A  17
ASN A  33
GLY A  35
 SO4  A 201 (-4.6A)
SO4  A 201 (-2.7A)
SO4  A 201 (-3.8A)
None
None
 0.52A 2axnA-1rkbA:
9.3		 2axnA-1rkbA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1rkb PROTEIN AD-004
(Homo
sapiens) 		4 / 6 TYR A  78
GLY A  35
ASP A  36
ASN A  33
 None
 1.28A 2g72A-1rkbA:
undetectable		 2g72A-1rkbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1rkb PROTEIN AD-004
(Homo
sapiens) 		5 / 10 ASP A  66
ARG A  87
PHE A  89
VAL A  76
ILE A  32
 None
 1.46A 2vn1B-1rkbA:
undetectable		 2vn1B-1rkbA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1rkb PROTEIN AD-004
(Homo
sapiens) 		3 / 3 GLY A  13
GLY A  15
THR A  17
 SO4  A 201 (-3.5A)
SO4  A 201 (-3.3A)
SO4  A 201 (-3.8A)
 0.41A 3si7B-1rkbA:
3.4		 3si7B-1rkbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rkb PROTEIN AD-004
(Homo
sapiens) 		5 / 10 ASP A  66
ARG A  87
PHE A  89
VAL A  76
ILE A  32
 None
 1.41A 4dz3B-1rkbA:
undetectable		 4dz3B-1rkbA:
21.79