SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		5 / 11 TYR A  48
TYR A  66
LEU A 205
HIS A  52
MET A  11
 None
 1.50A 1fmjA-1rkqA:
0.0		 1fmjA-1rkqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		5 / 10 TYR A  48
TYR A  66
LEU A 205
HIS A  52
MET A  11
 None
 1.47A 1fmjB-1rkqA:
0.0		 1fmjB-1rkqA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		4 / 6 ILE A   4
LYS A 267
ALA A 264
VAL A 234
 None
 1.01A 1hk1A-1rkqA:
undetectable		 1hk1A-1rkqA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		5 / 12 LEU A 100
LEU A  97
PHE A  96
LEU A  89
ILE A 171
 None
 1.11A 2pnjA-1rkqA:
2.7		 2pnjA-1rkqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		4 / 8 MET A 156
LEU A 111
ARG A  46
SER A 124
 None
 1.13A 2qd2A-1rkqA:
2.8		 2qd2A-1rkqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		5 / 12 ILE A   7
ALA A 264
ALA A  32
ILE A  22
LEU A  58
 None
 1.04A 3dauA-1rkqA:
undetectable		 3dauA-1rkqA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		5 / 12 SER A 204
LEU A 205
ASP A 225
ASP A  10
GLY A  45
 None
None
MG  A1273 ( 4.4A)
MG  A1273 ( 2.6A)
CL  A1272 (-3.7A)
 1.43A 4j7xF-1rkqA:
4.0		 4j7xF-1rkqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		3 / 3 CYH A  67
ASN A  39
LYS A  77
 None
 1.17A 4k50A-1rkqA:
undetectable		 4k50A-1rkqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		4 / 5 MET A 156
LEU A 111
ARG A  46
SER A 124
 None
 1.31A 4kmmB-1rkqA:
3.0		 4kmmB-1rkqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		5 / 9 VAL A  26
ALA A 262
GLY A  13
SER A 255
GLY A 260
 None
None
MG  A1273 ( 4.5A)
None
None
 1.41A 4mmeA-1rkqA:
undetectable		 4mmeA-1rkqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		4 / 8 ASP A 221
ASP A  10
ASP A 225
ILE A  68
 MG  A1273 (-2.6A)
MG  A1273 ( 2.6A)
MG  A1273 ( 4.4A)
None
 1.05A 4xjeA-1rkqA:
undetectable		 4xjeA-1rkqA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		4 / 8 ASP A 221
ASP A  10
ASP A 225
ILE A  68
 MG  A1273 (-2.6A)
MG  A1273 ( 2.6A)
MG  A1273 ( 4.4A)
None
 1.07A 5cfsA-1rkqA:
undetectable		 5cfsA-1rkqA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1rkq HYPOTHETICAL PROTEIN
YIDA
(Escherichia
coli) 		4 / 4 GLN A  76
THR A  83
THR A 200
LEU A 192
 None
 1.18A 5m5kA-1rkqA:
3.8		 5m5kA-1rkqA:
21.79