SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rkv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  12
ILE A  88
LEU A  89
SER A  90
 None
None
None
PO4  A 320 (-3.0A)
 0.91A 2byoA-1rkvA:
0.0		 2byoA-1rkvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 116
LEU A  55
LEU A  57
ILE A  60
LEU A  47
 None
 1.27A 3a50C-1rkvA:
undetectable		 3a50C-1rkvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 116
LEU A  55
LEU A  57
ILE A  60
LEU A  47
 None
 1.22A 3a50E-1rkvA:
undetectable		 3a50E-1rkvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  21
LEU A  50
LEU A 114
PHE A  96
THR A  24
 None
 1.34A 3fl9H-1rkvA:
undetectable		 3fl9H-1rkvA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 196
PHE A  84
ALA A   4
LEU A 191
 None
 0.85A 3t3zA-1rkvA:
undetectable		 3t3zA-1rkvA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 196
PHE A  84
ALA A   4
LEU A 191
 None
 0.87A 3t3zB-1rkvA:
undetectable		 3t3zB-1rkvA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 196
PHE A  84
ALA A   4
LEU A 191
 None
 0.84A 3t3zD-1rkvA:
undetectable		 3t3zD-1rkvA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  80
LEU A 191
ALA A 150
ILE A 148
ALA A   4
 None
 0.96A 4o2bD-1rkvA:
3.6		 4o2bD-1rkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 191
ALA A 150
ILE A 148
ALA A   4
ILE A 167
 None
 0.92A 4o2bD-1rkvA:
3.6		 4o2bD-1rkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 153
ASP A  38
ASP A  91
 MG  A 401 ( 3.9A)
None
PO4  A 320 (-4.6A)
 0.65A 4uckA-1rkvA:
undetectable		 4uckA-1rkvA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  80
LEU A 191
ALA A 150
ILE A 148
ALA A   4
 None
 1.01A 5xiwB-1rkvA:
3.7		 5xiwB-1rkvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 191
ALA A 150
ILE A 148
ALA A   4
ILE A 167
 None
 0.99A 5xiwB-1rkvA:
3.7		 5xiwB-1rkvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 196
ALA A 150
ILE A 148
ALA A   4
ILE A 167
 None
 0.95A 5xiwB-1rkvA:
3.7		 5xiwB-1rkvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  80
LEU A 191
ALA A 150
ILE A 148
ALA A   4
 None
 0.97A 5xiwD-1rkvA:
4.0		 5xiwD-1rkvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  54
LEU A  55
VAL A 122
LEU A  29
 None
 0.84A 6czmD-1rkvA:
undetectable
6czmF-1rkvA:
undetectable		 6czmD-1rkvA:
21.39
6czmF-1rkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1rkv HOMOSERINE KINASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A  10
ASP A   7
ILE A  88
 MG  A 402 ( 4.1A)
MG  A 401 ( 2.7A)
None
 0.61A 6dgxB-1rkvA:
undetectable		 6dgxB-1rkvA:
18.56