SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rlh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1rlh CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A 110
LEU A 108
GLY A  12
SER A  99
GLN A  95
 None
 1.28A 2e7fB-1rlhA:
undetectable		 2e7fB-1rlhA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1rlh CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ILE A 110
LEU A 108
GLY A  12
SER A  99
GLN A  95
 None
 1.23A 2ogyA-1rlhA:
undetectable		 2ogyA-1rlhA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1rlh CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 PHE A  40
TYR A  13
ILE A  79
LEU A  78
 None
 1.36A 3sueC-1rlhA:
undetectable		 3sueC-1rlhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1rlh CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 GLY A  37
ASP A  52
GLY A  53
VAL A  31
 None
 0.69A 4c5nC-1rlhA:
undetectable		 4c5nC-1rlhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 1rlh CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 GLU A  96
THR A  29
HIS A  30
 None
 0.82A 4q15A-1rlhA:
undetectable		 4q15A-1rlhA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 1rlh CONSERVED
HYPOTHETICAL PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 GLU A  96
THR A  29
HIS A  30
 None
 0.78A 4q15B-1rlhA:
undetectable		 4q15B-1rlhA:
15.91