SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		5 / 12 VAL A  18
LEU A  19
ASN A  15
ALA A 167
LEU A 168
 None
 0.84A 1fk6A-1rliA:
undetectable		 1fk6A-1rliA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		5 / 12 THR A  16
GLY A   8
ASP A  92
ILE A  91
MET A  83
 PT  A 606 (-4.2A)
None
None
None
PT  A 601 (-3.4A)
 0.98A 2b25A-1rliA:
undetectable		 2b25A-1rliA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		5 / 12 GLY A 153
GLY A 155
ASN A 156
GLY A 122
LEU A  19
 None
 0.89A 3ihtA-1rliA:
undetectable		 3ihtA-1rliA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		3 / 3 SER A  84
GLY A  85
THR A  86
 None
 0.17A 3k9wA-1rliA:
2.4		 3k9wA-1rliA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		5 / 12 PHE A 140
PHE A  74
ILE A  71
GLY A 149
PHE A 147
 None
 1.24A 3ps9A-1rliA:
2.9		 3ps9A-1rliA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		4 / 5 GLY A  13
ASP A  17
ARG A  11
GLN A  25
 None
 1.44A 3qx3A-1rliA:
2.9		 3qx3A-1rliA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		4 / 5 PHE A 136
ALA A 119
THR A  16
LEU A  87
 None
None
PT  A 606 (-4.2A)
None
 1.22A 3t3zC-1rliA:
undetectable		 3t3zC-1rliA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		6 / 12 LEU A 168
GLY A  13
GLY A  14
LEU A 162
ASN A   7
GLY A   9
 None
None
PT  A 606 ( 4.9A)
None
None
None
 1.26A 4dc3B-1rliA:
undetectable		 4dc3B-1rliA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1rli TRP REPRESSOR
BINDING PROTEIN
(Bacillus
subtilis) 		5 / 10 SER A  12
GLY A  13
ILE A 118
ALA A  20
PHE A 106
 None
 1.18A 5zjiA-1rliA:
undetectable
5zjiJ-1rliA:
0.0		 5zjiA-1rliA:
19.78
5zjiJ-1rliA:
12.50