SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rlm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 10 LEU A  51
GLN A  50
ASN A  46
THR A  13
GLY A  12
 None
None
GOL  A 804 (-4.2A)
None
MG  A 800 ( 4.5A)
 1.30A 1kvlA-1rlmA:
undetectable		 1kvlA-1rlmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 1rlm PHOSPHATASE
(Escherichia
coli) 		3 / 3 ASN A 218
ALA A 220
ASN A 238
 GOL  A 804 ( 4.7A)
None
None
 0.72A 1n4fA-1rlmA:
undetectable		 1n4fA-1rlmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 12 VAL A 161
SER A 150
LEU A 153
LEU A  97
LEU A 165
 None
GOL  A 804 (-3.0A)
None
None
None
 1.35A 1ya4B-1rlmA:
undetectable		 1ya4B-1rlmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 11 PHE A 149
PHE A 104
ILE A  93
GLY A  94
ILE A 172
 None
 1.01A 1z11A-1rlmA:
0.0		 1z11A-1rlmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 11 PHE A 149
PHE A 104
ILE A  93
GLY A  94
ILE A 172
 None
 1.03A 1z11B-1rlmA:
undetectable		 1z11B-1rlmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 10 PHE A 149
PHE A 104
ILE A  93
GLY A  94
ILE A 172
 None
 1.07A 1z11C-1rlmA:
0.0		 1z11C-1rlmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 10 PHE A 149
PHE A 104
ILE A  93
GLY A  94
ILE A 172
 None
 1.03A 1z11D-1rlmA:
0.0		 1z11D-1rlmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 1rlm PHOSPHATASE
(Escherichia
coli) 		4 / 6 ARG A  25
PHE A  26
ILE A 259
PHE A  40
 None
 1.19A 2qeiA-1rlmA:
0.0		 2qeiA-1rlmA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1rlm PHOSPHATASE
(Escherichia
coli) 		4 / 6 PHE A 269
PHE A 230
TYR A 245
VAL A   3
 None
 1.33A 3lb3B-1rlmA:
0.0		 3lb3B-1rlmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9X_B_ACTB502_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1rlm PHOSPHATASE
(Escherichia
coli) 		4 / 4 LYS A 148
GLU A  67
GLN A  47
TYR A 130
 GOL  A 804 ( 4.2A)
None
None
GOL  A 804 (-4.3A)
 1.43A 3r9xB-1rlmA:
3.1		 3r9xB-1rlmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1rlm PHOSPHATASE
(Escherichia
coli) 		4 / 5 ILE A 196
ALA A 212
HIS A 191
MET A 222
 None
 1.35A 4ac9B-1rlmA:
undetectable
4ac9C-1rlmA:
2.5		 4ac9B-1rlmA:
20.95
4ac9C-1rlmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rlm PHOSPHATASE
(Escherichia
coli) 		4 / 5 ILE A 196
ALA A 212
HIS A 191
MET A 222
 None
 1.32A 4acaB-1rlmA:
2.6
4acaC-1rlmA:
2.3		 4acaB-1rlmA:
20.95
4acaC-1rlmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 10 ALA A 236
PRO A 159
ILE A 162
ILE A 158
ASP A 155
 None
 1.07A 4dt8B-1rlmA:
undetectable		 4dt8B-1rlmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1rlm PHOSPHATASE
(Escherichia
coli) 		5 / 10 ALA A 236
PRO A 159
ILE A 162
ILE A 158
ASP A 155
 None
 1.15A 4dtaA-1rlmA:
2.1		 4dtaA-1rlmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1rlm PHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A 178
ASP A  11
GLN A  50
 GOL  A 804 (-3.2A)
GOL  A 804 (-4.9A)
None
 0.77A 4oltA-1rlmA:
undetectable
4oltB-1rlmA:
undetectable		 4oltA-1rlmA:
20.00
4oltB-1rlmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1rlm PHOSPHATASE
(Escherichia
coli) 		3 / 3 GLN A  50
SER A 178
ASP A  11
 None
GOL  A 804 (-3.2A)
GOL  A 804 (-4.9A)
 0.80A 4qwpA-1rlmA:
undetectable
4qwpB-1rlmA:
undetectable		 4qwpA-1rlmA:
20.00
4qwpB-1rlmA:
20.00