SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.22A 1os2A-1rm8A:
27.6		 1os2A-1rm8A:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 1os2D-1rm8A:
27.7		 1os2D-1rm8A:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.22A 1uttA-1rm8A:
28.0		 1uttA-1rm8A:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 1utzA-1rm8A:
28.2		 1utzA-1rm8A:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.19A 1utzB-1rm8A:
28.3		 1utzB-1rm8A:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 6 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.18A 1y93A-1rm8A:
28.1		 1y93A-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 256
HIS A 250
HIS A 246
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.73A 2einN-1rm8A:
undetectable		 2einN-1rm8A:
14.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.15A 2hu6A-1rm8A:
28.2		 2hu6A-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 7 THR A 220
ILE A 187
ASN A 138
PHE A 188
 None
 1.04A 2jc9A-1rm8A:
undetectable		 2jc9A-1rm8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 9 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.30A 2jihA-1rm8A:
10.3		 2jihA-1rm8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 8 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.28A 2jihB-1rm8A:
9.8		 2jihB-1rm8A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 6 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.27A 2ow9A-1rm8A:
27.1		 2ow9A-1rm8A:
47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 2ow9B-1rm8A:
26.9		 2ow9B-1rm8A:
47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.20A 2ozrC-1rm8A:
27.2		 2ozrC-1rm8A:
47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.18A 2ozrD-1rm8A:
27.4		 2ozrD-1rm8A:
47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.22A 2ozrE-1rm8A:
26.8		 2ozrE-1rm8A:
47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 246
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.25A 2ozrF-1rm8A:
26.6		 2ozrF-1rm8A:
47.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 208
GLU A 247
HIS A 250
 ZN  A 501 (-3.2A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
 0.55A 3ba0A-1rm8A:
25.5		 3ba0A-1rm8A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 256
HIS A 250
HIS A 246
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.76A 3bvdA-1rm8A:
undetectable		 3bvdA-1rm8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 9 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.34A 3hy7A-1rm8A:
10.7		 3hy7A-1rm8A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 9 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.29A 3hy7B-1rm8A:
10.6		 3hy7B-1rm8A:
26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 3kecA-1rm8A:
27.1		 3kecA-1rm8A:
48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 246
GLU A 247
HIS A 250
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
 0.21A 3kecB-1rm8A:
26.8		 3kecB-1rm8A:
48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.26A 3likA-1rm8A:
28.2		 3likA-1rm8A:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.20A 3lilA-1rm8A:
28.3		 3lilA-1rm8A:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.21A 3ljgA-1rm8A:
28.0		 3ljgA-1rm8A:
50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.25A 3lkaA-1rm8A:
28.2		 3lkaA-1rm8A:
51.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 7 LEU A 278
VAL A 162
VAL A 245
ASP A 157
 None
 0.94A 3rgfA-1rm8A:
undetectable		 3rgfA-1rm8A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 256
HIS A 250
HIS A 246
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.77A 3s38A-1rm8A:
undetectable		 3s38A-1rm8A:
16.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 6 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.32A 4a7bA-1rm8A:
27.3		 4a7bA-1rm8A:
48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
 0.31A 4a7bB-1rm8A:
27.1		 4a7bB-1rm8A:
48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.18A 5n5jA-1rm8A:
28.1		 5n5jA-1rm8A:
51.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.16A 5n5kA-1rm8A:
27.8		 5n5kA-1rm8A:
50.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 7 GLN A 287
GLY A 285
GLN A 269
ASP A 259
 None
 1.07A 5vlmC-1rm8A:
0.3		 5vlmC-1rm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 8 GLN A 287
GLY A 285
GLN A 269
ASP A 259
 None
 1.07A 5vlmD-1rm8A:
undetectable		 5vlmD-1rm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 7 GLN A 287
GLY A 285
GLN A 269
ASP A 259
 None
 1.01A 5vlmE-1rm8A:
0.3		 5vlmE-1rm8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 256
HIS A 250
HIS A 246
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.68A 5x1fN-1rm8A:
undetectable		 5x1fN-1rm8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 8 ASP A 195
SER A 197
TYR A 210
GLY A 253
 ZN  A 501 (-2.3A)
None
None
None
 1.01A 6giqL-1rm8A:
0.0
6giqP-1rm8A:
0.0
6giqT-1rm8A:
undetectable		 6giqL-1rm8A:
17.59
6giqP-1rm8A:
19.09
6giqT-1rm8A:
24.53