SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rmg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		6 / 12 THR A  64
VAL A  66
ILE A  55
ALA A  28
ALA A  39
ILE A  23
 None
 0.95A 1bx4A-1rmgA:
undetectable		 1bx4A-1rmgA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 6 LEU A 103
ILE A 186
TYR A 164
VAL A 135
 None
None
MAN  A 431 ( 4.2A)
None
 1.10A 1db1A-1rmgA:
undetectable		 1db1A-1rmgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 6 THR A 243
ASN A 217
LEU A 391
ASP A 390
 None
 1.37A 1mxdA-1rmgA:
undetectable		 1mxdA-1rmgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		3 / 3 LEU A 266
TYR A 250
GLY A 221
 None
 0.48A 2ocuA-1rmgA:
undetectable		 2ocuA-1rmgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 5 VAL A 241
TYR A 238
VAL A 200
SER A 219
 None
 1.29A 2x45A-1rmgA:
0.0		 2x45A-1rmgA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 4 VAL A 241
TYR A 238
VAL A 200
SER A 219
 None
 1.33A 2x45B-1rmgA:
0.0		 2x45B-1rmgA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 5 VAL A 241
TYR A 238
VAL A 200
SER A 219
 None
 1.28A 2x45C-1rmgA:
0.0		 2x45C-1rmgA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		3 / 3 TRP A 218
VAL A 193
TRP A 244
 None
 1.35A 2y6nC-1rmgA:
undetectable
2y6nD-1rmgA:
undetectable		 2y6nC-1rmgA:
3.12
2y6nD-1rmgA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 11 GLY A 178
THR A 201
ASP A 147
ALA A 148
ASP A 177
 None
 1.36A 3id5B-1rmgA:
undetectable		 3id5B-1rmgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 11 GLY A 178
THR A 201
ASP A 147
ALA A 148
ASP A 177
 None
 1.36A 3id5F-1rmgA:
undetectable		 3id5F-1rmgA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 12 ALA A 148
GLY A 114
GLY A 170
LEU A 176
ALA A 127
 None
 1.04A 3ou6A-1rmgA:
undetectable		 3ou6A-1rmgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 12 ALA A 148
GLY A 114
GLY A 170
LEU A 176
ALA A 127
 None
 1.06A 3ou6B-1rmgA:
undetectable		 3ou6B-1rmgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 12 ALA A 148
GLY A 114
GLY A 170
LEU A 176
ALA A 127
 None
 1.04A 3ou7B-1rmgA:
undetectable		 3ou7B-1rmgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 6 THR A 243
GLN A 248
ILE A 214
SER A 246
 None
 1.22A 3peoG-1rmgA:
undetectable		 3peoG-1rmgA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 12 VAL A 140
VAL A 211
PHE A 153
MET A 155
VAL A   6
 None
 1.22A 4nc3A-1rmgA:
undetectable		 4nc3A-1rmgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 12 VAL A  53
ILE A  93
VAL A  66
LEU A  68
ALA A  39
 None
 1.10A 4o1zB-1rmgA:
undetectable		 4o1zB-1rmgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		3 / 3 ASP A 279
ASN A 247
SER A 254
 None
 0.66A 4obwA-1rmgA:
undetectable		 4obwA-1rmgA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 7 THR A 367
TYR A 369
THR A 370
SER A 352
 MAN  A 447 (-2.4A)
None
BMA  A 427 (-2.2A)
BMA  A 427 ( 4.3A)
 1.14A 5b6iA-1rmgA:
undetectable		 5b6iA-1rmgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		4 / 6 THR A 367
TYR A 369
THR A 370
SER A 352
 MAN  A 447 (-2.4A)
None
BMA  A 427 (-2.2A)
BMA  A 427 ( 4.3A)
 1.15A 5b6iB-1rmgA:
0.0		 5b6iB-1rmgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		5 / 12 SER A 213
ILE A 179
HIS A 141
VAL A 163
VAL A 181
 None
 0.97A 5dpdA-1rmgA:
undetectable		 5dpdA-1rmgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1rmg RHAMNOGALACTURONASE
A
(Aspergillus
aculeatus) 		6 / 12 THR A  64
VAL A  66
ILE A  55
ALA A  28
ALA A  39
ILE A  23
 None
 1.00A 5kb6A-1rmgA:
undetectable		 5kb6A-1rmgA:
19.60