SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1rni ORF904
(Sulfolobus
islandicus) 		5 / 12 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.17A 1hrkA-1rniA:
undetectable		 1hrkA-1rniA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 1rni ORF904
(Sulfolobus
islandicus) 		4 / 6 SER A 150
ASP A 152
PRO A 154
VAL A 108
 None
 1.29A 2hdnI-1rniA:
undetectable
2hdnJ-1rniA:
undetectable
2hdnL-1rniA:
undetectable		 2hdnI-1rniA:
9.39
2hdnJ-1rniA:
20.23
2hdnL-1rniA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1rni ORF904
(Sulfolobus
islandicus) 		5 / 12 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.15A 2hrcB-1rniA:
undetectable		 2hrcB-1rniA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 1rni ORF904
(Sulfolobus
islandicus) 		4 / 5 GLY A 232
TRP A 121
ARG A 234
LEU A 235
 None
 1.34A 2j2pD-1rniA:
0.0
2j2pF-1rniA:
0.0		 2j2pD-1rniA:
21.61
2j2pF-1rniA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1rni ORF904
(Sulfolobus
islandicus) 		4 / 5 LEU A 149
ILE A 153
SER A 174
GLY A 102
 None
 0.89A 2otfA-1rniA:
undetectable		 2otfA-1rniA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rni ORF904
(Sulfolobus
islandicus) 		5 / 12 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.14A 2po5A-1rniA:
undetectable		 2po5A-1rniA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1rni ORF904
(Sulfolobus
islandicus) 		5 / 9 LEU A 118
GLU A 116
ILE A 144
GLY A 143
GLY A 142
 None
 1.17A 2qmmA-1rniA:
undetectable		 2qmmA-1rniA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1rni ORF904
(Sulfolobus
islandicus) 		4 / 7 TYR A  98
ILE A 100
GLY A 181
LEU A 209
 None
 1.02A 2vctD-1rniA:
0.0		 2vctD-1rniA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1rni ORF904
(Sulfolobus
islandicus) 		5 / 11 LEU A 172
ILE A 170
PHE A 162
SER A 240
VAL A 219
 None
 1.35A 3a9eB-1rniA:
undetectable		 3a9eB-1rniA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1rni ORF904
(Sulfolobus
islandicus) 		6 / 12 ILE A 169
LEU A 247
VAL A 108
PHE A 112
LEU A 224
VAL A 148
 None
 1.29A 3w68B-1rniA:
undetectable		 3w68B-1rniA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rni ORF904
(Sulfolobus
islandicus) 		4 / 8 LEU A 182
PHE A  50
ILE A 100
THR A 134
 None
 0.87A 5eseA-1rniA:
undetectable		 5eseA-1rniA:
19.26