SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ro5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI
(Pseudomonas
aeruginosa) 		4 / 5 HIS A  20
TYR A  53
TYR A  46
PRO A  51
 None
 1.44A 2ombA-1ro5A:
undetectable
2ombB-1ro5A:
undetectable		 2ombA-1ro5A:
21.93
2ombB-1ro5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 146
LYS A 150
GLY A 156
LEU A 188
 None
SO4  A 402 (-4.7A)
None
None
 1.07A 3bjwE-1ro5A:
undetectable		 3bjwE-1ro5A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 181
VAL A 159
VAL A 192
LEU A 193
ILE A 186
 None
 1.40A 3elzA-1ro5A:
undetectable		 3elzA-1ro5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 161
VAL A 143
HIS A 165
GLU A 171
 None
None
None
SO4  A 404 ( 4.9A)
 1.23A 5ad9A-1ro5A:
undetectable
5ad9B-1ro5A:
undetectable		 5ad9A-1ro5A:
20.41
5ad9B-1ro5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI
(Pseudomonas
aeruginosa) 		5 / 7 GLY A   6
LEU A  22
ILE A  71
LEU A 128
ILE A 107
 None
 1.17A 5vkqA-1ro5A:
undetectable
5vkqB-1ro5A:
undetectable		 5vkqA-1ro5A:
7.69
5vkqB-1ro5A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI
(Pseudomonas
aeruginosa) 		5 / 8 GLY A   6
LEU A  22
ILE A  71
LEU A 128
ILE A 107
 None
 1.15A 5vkqB-1ro5A:
undetectable
5vkqC-1ro5A:
undetectable		 5vkqB-1ro5A:
7.69
5vkqC-1ro5A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI
(Pseudomonas
aeruginosa) 		4 / 8 GLN A  57
VAL A   3
ALA A 127
TYR A 131
 None
 0.90A 6cduD-1ro5A:
undetectable
6cduE-1ro5A:
undetectable		 6cduD-1ro5A:
22.99
6cduE-1ro5A:
22.99