SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 8 GLU A 101
ILE A  68
GLU A  57
ALA A  54
VAL A  44
 None
 0.86A 1a29A-1rp0A:
undetectable		 1a29A-1rp0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		3 / 3 ALA A 161
VAL A 163
TRP A 160
 None
 0.89A 1bdwA-1rp0A:
undetectable
1bdwB-1rp0A:
undetectable		 1bdwA-1rp0A:
4.80
1bdwB-1rp0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 9 GLU A 101
ILE A  68
GLU A  57
ALA A  54
VAL A  44
 None
 0.88A 1ctrA-1rp0A:
undetectable		 1ctrA-1rp0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 1gtnB-1rp0A:
0.0
1gtnC-1rp0A:
undetectable		 1gtnB-1rp0A:
14.98
1gtnC-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		4 / 8 THR A 239
GLY A  46
ALA A  55
ILE A  68
 None
AHZ  A 600 (-3.1A)
None
None
 0.82A 1gtnE-1rp0A:
undetectable
1gtnF-1rp0A:
undetectable		 1gtnE-1rp0A:
14.98
1gtnF-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.12A 1gtnH-1rp0A:
undetectable
1gtnI-1rp0A:
undetectable		 1gtnH-1rp0A:
14.98
1gtnI-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 11 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.13A 1gtnM-1rp0A:
undetectable
1gtnN-1rp0A:
undetectable		 1gtnM-1rp0A:
14.98
1gtnN-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.20A 1gtnU-1rp0A:
undetectable
1gtnV-1rp0A:
undetectable		 1gtnU-1rp0A:
14.98
1gtnV-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.71A 1hshA-1rp0A:
undetectable		 1hshA-1rp0A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 11 PRO A  75
LEU A  52
VAL A 135
VAL A  44
LEU A 130
 None
 1.41A 1lwcA-1rp0A:
undetectable		 1lwcA-1rp0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.12A 1utdT-1rp0A:
undetectable
1utdU-1rp0A:
0.0		 1utdT-1rp0A:
14.98
1utdU-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A  79
GLY A  77
GLY A  78
PHE A 256
ASP A 190
 None
AHZ  A 600 (-3.2A)
AHZ  A 600 (-3.6A)
None
ZN  A 500 ( 2.5A)
 0.88A 2c49A-1rp0A:
4.6		 2c49A-1rp0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A  79
GLY A  77
GLY A  78
PHE A 256
ASP A 190
 None
AHZ  A 600 (-3.2A)
AHZ  A 600 (-3.6A)
None
ZN  A 500 ( 2.5A)
 0.92A 2pkmA-1rp0A:
4.9		 2pkmA-1rp0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A  79
GLY A  77
GLY A  78
PHE A 256
GLY A 188
 None
AHZ  A 600 (-3.2A)
AHZ  A 600 (-3.6A)
None
AHZ  A 600 (-3.3A)
 0.88A 2pkmA-1rp0A:
4.9		 2pkmA-1rp0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.78A 2rkgA-1rp0A:
undetectable		 2rkgA-1rp0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.80A 2rkgB-1rp0A:
undetectable		 2rkgB-1rp0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 ILE A 280
ALA A  88
ALA A 118
THR A 122
MET A 260
 None
 1.35A 2x2nD-1rp0A:
undetectable		 2x2nD-1rp0A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 THR A 239
GLY A 267
GLY A 263
SER A 262
ALA A  55
 None
 0.98A 2yvlA-1rp0A:
3.1		 2yvlA-1rp0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 11 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.72A 3ebzB-1rp0A:
undetectable		 3ebzB-1rp0A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		4 / 7 GLY A 257
VAL A  91
VAL A 226
GLN A 264
 None
 0.82A 3fi0E-1rp0A:
undetectable		 3fi0E-1rp0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		3 / 3 LEU A 276
PRO A 277
LEU A 271
 None
 0.56A 3hcrA-1rp0A:
undetectable		 3hcrA-1rp0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A  46
ALA A  47
GLU A  70
SER A  72
ALA A 143
 AHZ  A 600 (-3.1A)
None
AHZ  A 600 (-2.7A)
None
AHZ  A 600 (-3.9A)
 1.12A 3id6C-1rp0A:
3.8		 3id6C-1rp0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A  46
ALA A  47
GLU A  70
SER A  72
ALA A 143
 AHZ  A 600 (-3.1A)
None
AHZ  A 600 (-2.7A)
None
AHZ  A 600 (-3.9A)
 1.12A 3nmuA-1rp0A:
undetectable
3nmuF-1rp0A:
3.1		 3nmuA-1rp0A:
21.74
3nmuF-1rp0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 11 GLY A  46
ALA A  47
ILE A  69
GLU A  70
ALA A 143
 AHZ  A 600 (-3.1A)
None
None
AHZ  A 600 (-2.7A)
AHZ  A 600 (-3.9A)
 1.06A 3nmuB-1rp0A:
undetectable
3nmuJ-1rp0A:
3.1		 3nmuB-1rp0A:
21.74
3nmuJ-1rp0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 240
GLY A  48
SER A  49
MET A 259
ALA A 195
 AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.4A)
AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.3A)
None
 1.10A 3ou6A-1rp0A:
2.6		 3ou6A-1rp0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 240
GLY A  48
SER A  49
MET A 259
ALA A 195
 AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.4A)
AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.3A)
None
 1.08A 3ou6B-1rp0A:
2.6		 3ou6B-1rp0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 240
GLY A  48
SER A  49
MET A 259
ALA A 195
 AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.4A)
AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.3A)
None
 1.08A 3ou7B-1rp0A:
2.6		 3ou7B-1rp0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 8 GLY A  77
GLY A  76
GLY A  51
ILE A  68
LEU A 129
 AHZ  A 600 (-3.2A)
None
None
None
None
 1.27A 3v1nA-1rp0A:
undetectable		 3v1nA-1rp0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		4 / 8 GLN A  65
ILE A  69
VAL A 141
PHE A 138
 None
 0.67A 4dx7B-1rp0A:
undetectable		 4dx7B-1rp0A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 8 PRO A  75
LEU A  52
VAL A 135
VAL A  44
LEU A 130
 None
 1.47A 4pwdA-1rp0A:
undetectable		 4pwdA-1rp0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		4 / 7 ALA A  54
ALA A 270
MET A 259
THR A 239
 None
None
AHZ  A 600 (-3.3A)
None
 1.03A 4qw0K-1rp0A:
undetectable		 4qw0K-1rp0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		4 / 7 ALA A  54
ALA A 270
MET A 259
THR A 239
 None
None
AHZ  A 600 (-3.3A)
None
 1.03A 4qw0Y-1rp0A:
undetectable		 4qw0Y-1rp0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.72A 5e5jA-1rp0A:
undetectable		 5e5jA-1rp0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.72A 5e5kA-1rp0A:
undetectable		 5e5kA-1rp0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		6 / 12 GLY A  78
GLY A 240
GLY A 188
GLY A  48
ASP A 247
ILE A 225
 AHZ  A 600 (-3.6A)
AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.3A)
AHZ  A 600 (-3.4A)
None
None
 1.50A 5e9qA-1rp0A:
undetectable		 5e9qA-1rp0A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.08A 5eeuF-1rp0A:
undetectable
5eeuG-1rp0A:
undetectable		 5eeuF-1rp0A:
14.98
5eeuG-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.06A 5eeuI-1rp0A:
undetectable
5eeuJ-1rp0A:
undetectable		 5eeuI-1rp0A:
14.98
5eeuJ-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5eeuO-1rp0A:
undetectable
5eeuP-1rp0A:
undetectable		 5eeuO-1rp0A:
14.98
5eeuP-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 5eevF-1rp0A:
undetectable
5eevG-1rp0A:
undetectable		 5eevF-1rp0A:
14.98
5eevG-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.06A 5eevI-1rp0A:
undetectable
5eevJ-1rp0A:
undetectable		 5eevI-1rp0A:
14.98
5eevJ-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5eevO-1rp0A:
undetectable
5eevP-1rp0A:
0.0		 5eevO-1rp0A:
14.98
5eevP-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 5eewF-1rp0A:
undetectable
5eewG-1rp0A:
undetectable		 5eewF-1rp0A:
14.98
5eewG-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.06A 5eewI-1rp0A:
undetectable
5eewJ-1rp0A:
undetectable		 5eewI-1rp0A:
14.98
5eewJ-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5eewO-1rp0A:
0.0
5eewP-1rp0A:
undetectable		 5eewO-1rp0A:
14.98
5eewP-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 5eexF-1rp0A:
0.0
5eexG-1rp0A:
undetectable		 5eexF-1rp0A:
14.98
5eexG-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5eexO-1rp0A:
undetectable
5eexP-1rp0A:
undetectable		 5eexO-1rp0A:
14.98
5eexP-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 5eeyF-1rp0A:
undetectable
5eeyG-1rp0A:
undetectable		 5eeyF-1rp0A:
14.98
5eeyG-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5eeyO-1rp0A:
undetectable
5eeyP-1rp0A:
undetectable		 5eeyO-1rp0A:
14.98
5eeyP-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 5eezF-1rp0A:
undetectable
5eezG-1rp0A:
undetectable		 5eezF-1rp0A:
14.98
5eezG-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5eezO-1rp0A:
undetectable
5eezP-1rp0A:
undetectable		 5eezO-1rp0A:
14.98
5eezP-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 5ef0F-1rp0A:
undetectable
5ef0G-1rp0A:
undetectable		 5ef0F-1rp0A:
14.98
5ef0G-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5ef0O-1rp0A:
0.0
5ef0P-1rp0A:
undetectable		 5ef0O-1rp0A:
14.98
5ef0P-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.09A 5ef1F-1rp0A:
undetectable
5ef1G-1rp0A:
undetectable		 5ef1F-1rp0A:
14.98
5ef1G-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5ef1O-1rp0A:
0.0
5ef1P-1rp0A:
undetectable		 5ef1O-1rp0A:
14.98
5ef1P-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.10A 5ef2F-1rp0A:
undetectable
5ef2G-1rp0A:
undetectable		 5ef2F-1rp0A:
14.98
5ef2G-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5ef2O-1rp0A:
0.0
5ef2P-1rp0A:
undetectable		 5ef2O-1rp0A:
14.98
5ef2P-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 THR A 239
ALA A  54
GLY A  46
ALA A  55
ILE A  68
 None
None
AHZ  A 600 (-3.1A)
None
None
 1.10A 5ef3F-1rp0A:
undetectable
5ef3G-1rp0A:
undetectable		 5ef3F-1rp0A:
14.98
5ef3G-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 10 GLY A  46
ALA A  55
ILE A  68
THR A 239
ALA A  54
 AHZ  A 600 (-3.1A)
None
None
None
None
 1.10A 5ef3O-1rp0A:
0.0
5ef3P-1rp0A:
undetectable		 5ef3O-1rp0A:
14.98
5ef3P-1rp0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 9 LEU A 129
LEU A  52
ALA A  67
VAL A  43
ALA A  47
 None
 1.50A 5g44A-1rp0A:
undetectable		 5g44A-1rp0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 11 PRO A  75
LEU A  52
VAL A 135
VAL A  44
LEU A 130
 None
 1.38A 5hbmA-1rp0A:
0.0		 5hbmA-1rp0A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A 161
PHE A 193
GLY A  46
GLU A  70
SER A  72
 None
AHZ  A 600 (-4.7A)
AHZ  A 600 (-3.1A)
AHZ  A 600 (-2.7A)
None
 1.33A 5hfjA-1rp0A:
undetectable		 5hfjA-1rp0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A 161
PHE A 193
GLY A  46
GLU A  70
SER A  72
 None
AHZ  A 600 (-4.7A)
AHZ  A 600 (-3.1A)
AHZ  A 600 (-2.7A)
None
 1.09A 5hfjD-1rp0A:
undetectable		 5hfjD-1rp0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 ALA A 161
PHE A 193
GLY A  46
GLU A  70
SER A  72
 None
AHZ  A 600 (-4.7A)
AHZ  A 600 (-3.1A)
AHZ  A 600 (-2.7A)
None
 1.32A 5hfjE-1rp0A:
undetectable		 5hfjE-1rp0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 240
GLY A  48
SER A  49
MET A 259
HIS A 189
 AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.4A)
AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.3A)
ZN  A 500 ( 3.2A)
 1.11A 5hikA-1rp0A:
2.7		 5hikA-1rp0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.74A 5t8hA-1rp0A:
undetectable		 5t8hA-1rp0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
ALA A 195
ILE A 246
VAL A 238
GLY A 240
 None
None
None
None
AHZ  A 600 (-3.5A)
 0.75A 5t8hB-1rp0A:
undetectable		 5t8hB-1rp0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		4 / 7 LEU A 137
ALA A  47
ILE A 125
LEU A 129
 None
 0.92A 5te8A-1rp0A:
undetectable		 5te8A-1rp0A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 VAL A 183
LEU A 146
VAL A 148
GLY A 154
VAL A 232
 None
 1.10A 6a94B-1rp0A:
undetectable		 6a94B-1rp0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 PHE A 121
GLY A  51
GLY A 263
ALA A 266
ILE A  68
 None
 1.13A 6b3aA-1rp0A:
2.4		 6b3aA-1rp0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		5 / 12 PHE A 121
GLY A  51
GLY A 263
ALA A 266
ILE A  68
 None
 1.15A 6b3bA-1rp0A:
undetectable		 6b3bA-1rp0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1rp0 THIAZOLE
BIOSYNTHETIC ENZYME
(Arabidopsis
thaliana) 		4 / 7 PHE A  98
GLY A  48
ALA A  47
LEU A 129
 None
AHZ  A 600 (-3.4A)
None
None
 0.72A 6dwnB-1rp0A:
0.0		 6dwnB-1rp0A:
16.25