SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 8 LEU A 175
GLY A 150
ILE A 172
MET A 221
 None
 0.93A 1n13A-1rp1A:
undetectable
1n13F-1rp1A:
undetectable		 1n13A-1rp1A:
8.24
1n13F-1rp1A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 8 GLY A  60
THR A  42
ILE A  59
GLN A  50
 None
 0.98A 2a8tB-1rp1A:
0.0		 2a8tB-1rp1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 11 ILE A 344
ILE A 420
GLY A 348
LEU A 444
PHE A 400
 None
 1.22A 2azyA-1rp1A:
undetectable		 2azyA-1rp1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 11 HIS A  75
TRP A 106
VAL A 124
GLY A   9
GLU A   2
 None
 1.14A 2h9tH-1rp1A:
undetectable		 2h9tH-1rp1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		3 / 3 ALA A 155
GLY A 216
SER A 266
 None
 0.60A 2ivuA-1rp1A:
undetectable		 2ivuA-1rp1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 6 ARG A 122
THR A 115
ALA A 118
PRO A  24
 None
 1.28A 2ql8A-1rp1A:
0.0
2ql8B-1rp1A:
0.0		 2ql8A-1rp1A:
15.61
2ql8B-1rp1A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 8 ILE A 172
MET A 221
LEU A 175
GLY A 150
 None
 0.83A 2qqcH-1rp1A:
undetectable
2qqcK-1rp1A:
undetectable		 2qqcH-1rp1A:
12.22
2qqcK-1rp1A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 ALA A 118
ALA A  18
THR A  20
GLY A 184
GLN A 219
 None
 1.23A 2ve3B-1rp1A:
0.0		 2ve3B-1rp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 8 ASP A 205
HIS A 263
PHE A  77
GLY A 214
 None
 0.91A 3c0zB-1rp1A:
undetectable		 3c0zB-1rp1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 8 LYS A 268
ARG A 337
MET A 234
GLU A  82
 None
 1.02A 3dh0A-1rp1A:
2.1		 3dh0A-1rp1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 10 ALA A 161
VAL A 124
GLY A 150
ILE A 149
VAL A 128
 None
 1.03A 3t3cB-1rp1A:
undetectable		 3t3cB-1rp1A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 5 HIS A 151
LEU A 248
LEU A 213
ASP A 247
 None
 1.23A 4aqlA-1rp1A:
undetectable		 4aqlA-1rp1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 5 PHE A  77
ILE A 251
GLY A 250
THR A 255
 None
 0.88A 4ejjC-1rp1A:
undetectable		 4ejjC-1rp1A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 GLU A 160
VAL A 123
PRO A  29
THR A  20
GLY A  19
 None
 1.39A 4hvcA-1rp1A:
undetectable		 4hvcA-1rp1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 SER A 266
LEU A 175
ASP A 192
MET A 221
GLY A 222
 None
None
CA  A 501 (-3.4A)
None
None
 1.16A 4j7xF-1rp1A:
3.1		 4j7xF-1rp1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		3 / 3 LEU A 169
ARG A 171
MET A 307
 None
 0.92A 4m11C-1rp1A:
0.0		 4m11C-1rp1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 VAL A 342
ILE A 395
VAL A 392
LEU A 390
LEU A 359
 None
 1.42A 4m11D-1rp1A:
0.0		 4m11D-1rp1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 GLU A 160
VAL A 123
PRO A  29
THR A  20
GLY A  19
 None
 1.36A 4olfA-1rp1A:
2.6		 4olfA-1rp1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 4 THR A 115
GLY A 250
ASP A 247
SER A 113
 None
 1.11A 4rfqA-1rp1A:
undetectable		 4rfqA-1rp1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 11 PHE A 280
GLY A 174
LEU A 175
LEU A 224
ALA A 311
 None
 1.18A 4wnuA-1rp1A:
undetectable		 4wnuA-1rp1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		4 / 6 LEU A 264
SER A 152
PRO A 177
GLU A 179
 None
 1.28A 5b8iA-1rp1A:
undetectable		 5b8iA-1rp1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		3 / 3 THR A 204
SER A 266
TYR A 269
 None
 0.89A 5jsdB-1rp1A:
undetectable		 5jsdB-1rp1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		3 / 3 LYS A 419
LEU A 359
ILE A 371
 None
 0.81A 5kc4A-1rp1A:
undetectable		 5kc4A-1rp1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 ILE A 420
PHE A 400
ALA A 417
ILE A 375
GLY A 353
 None
 0.92A 5veuB-1rp1A:
undetectable		 5veuB-1rp1A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 GLU A 160
VAL A 123
PRO A  29
ARG A 122
THR A  20
 None
 1.46A 5xioA-1rp1A:
2.8		 5xioA-1rp1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1
(Canis
lupus) 		5 / 12 GLU A 160
VAL A 123
PRO A  29
THR A  20
GLY A  19
 None
 1.39A 6mn8A-1rp1A:
undetectable		 6mn8A-1rp1A:
20.87