SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
ANTI SIGMA FACTOR
FLGM
(Aquifex
aeolicus;
Aquifex
aeolicus) 		5 / 12 ASP B  35
LEU B  39
LEU A  19
ILE A  15
THR B  17
 None
 1.00A 1ra2A-1rp3B:
undetectable		 1ra2A-1rp3B:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
ANTI SIGMA FACTOR
FLGM
(Aquifex
aeolicus;
Aquifex
aeolicus) 		5 / 12 ASP B  35
LEU B  39
LEU A  19
ILE A  15
THR B  17
 None
 1.00A 1rb2A-1rp3B:
undetectable		 1rb2A-1rp3B:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
ANTI SIGMA FACTOR
FLGM
(Aquifex
aeolicus;
Aquifex
aeolicus) 		5 / 12 ASP B  35
LEU B  39
LEU A  19
ILE A  15
THR B  17
 None
 1.02A 1rb2B-1rp3B:
undetectable		 1rb2B-1rp3B:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1rp3 ANTI SIGMA FACTOR
FLGM
RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
(Aquifex
aeolicus) 		6 / 12 ILE A  48
ASP B  35
LEU B  39
LEU A  19
ILE B  11
THR B  17
 None
 1.49A 2w3vA-1rp3A:
undetectable		 2w3vA-1rp3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
(Aquifex
aeolicus) 		5 / 8 VAL A 206
LEU A 210
ILE A 196
VAL A 192
LEU A 191
 None
 1.42A 3kp6A-1rp3A:
2.2
3kp6B-1rp3A:
4.6		 3kp6A-1rp3A:
22.69
3kp6B-1rp3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
(Aquifex
aeolicus) 		5 / 9 ILE A  29
GLU A 145
ARG A  82
PHE A 138
LEU A  33
 None
 1.47A 3mjrA-1rp3A:
0.0		 3mjrA-1rp3A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1rp3 ANTI SIGMA FACTOR
FLGM
RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
(Aquifex
aeolicus) 		6 / 12 LEU A 144
PHE A 148
ILE A 193
ALA A 181
ILE B  84
VAL B  79
 None
 1.28A 4nkxB-1rp3A:
undetectable		 4nkxB-1rp3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1rp3 ANTI SIGMA FACTOR
FLGM
RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
(Aquifex
aeolicus) 		6 / 12 LEU B  46
LEU B   7
ILE B  11
LEU A  16
ILE A  48
ILE A  51
 None
 1.44A 4odrA-1rp3B:
undetectable
4odrB-1rp3B:
undetectable		 4odrA-1rp3B:
22.50
4odrB-1rp3B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
(Aquifex
aeolicus) 		3 / 3 VAL A 118
LEU A 122
VAL A 101
 None
 0.52A 4wq4A-1rp3A:
undetectable		 4wq4A-1rp3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1rp3 RNA POLYMERASE SIGMA
FACTOR SIGMA-28
(FLIA)
(Aquifex
aeolicus) 		5 / 9 LEU A 228
LEU A 142
ILE A 193
PHE A 138
ILE A  29
 None
 0.88A 5vkqC-1rp3A:
2.2
5vkqD-1rp3A:
2.2		 5vkqC-1rp3A:
9.54
5vkqD-1rp3A:
9.54