SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 6 GLN A1143
CYH A1095
VAL A 997
GLY A1103
 None
 1.16A 1ekjC-1rpmA:
undetectable
1ekjD-1rpmA:
undetectable		 1ekjC-1rpmA:
21.68
1ekjD-1rpmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 6 CYH A1095
VAL A 997
GLY A1103
GLN A1143
 None
 1.14A 1ekjC-1rpmA:
undetectable
1ekjD-1rpmA:
undetectable		 1ekjC-1rpmA:
21.68
1ekjD-1rpmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 8 GLY A 973
THR A 971
VAL A1092
ILE A 995
 None
 0.79A 2a1mB-1rpmA:
undetectable		 2a1mB-1rpmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		3 / 3 HIS A1057
ILE A 995
LEU A1073
 None
 0.71A 2kceA-1rpmA:
undetectable		 2kceA-1rpmA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		3 / 3 ASN A 927
ASN A 955
ARG A1134
 None
 0.78A 2rlcA-1rpmA:
undetectable		 2rlcA-1rpmA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		3 / 3 ARG A 939
ASP A 981
ASN A 923
 None
 0.88A 2zzmA-1rpmA:
undetectable		 2zzmA-1rpmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 6 VAL A1145
VAL A1138
PHE A 907
GLU A1141
 None
 1.42A 3n61A-1rpmA:
0.0
3n61B-1rpmA:
0.0		 3n61A-1rpmA:
21.03
3n61B-1rpmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 8 GLU A 922
ASP A 916
LYS A 926
ILE A 933
 None
 0.89A 4kttB-1rpmA:
undetectable		 4kttB-1rpmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		5 / 12 VAL A1093
ALA A 970
PHE A1076
PHE A1105
GLY A1103
 None
 1.28A 4mm6A-1rpmA:
0.1		 4mm6A-1rpmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 8 SER A1084
SER A 993
ILE A1037
GLU A1052
 None
 1.19A 4ms4A-1rpmA:
2.5		 4ms4A-1rpmA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 8 GLU A 922
ASP A 916
LYS A 926
ILE A 933
 None
 0.86A 4ndnB-1rpmA:
undetectable		 4ndnB-1rpmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		5 / 12 ALA A 970
ILE A1147
GLY A1100
ILE A 959
VAL A1127
 None
 0.85A 4nkxA-1rpmA:
undetectable		 4nkxA-1rpmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		6 / 12 ALA A 970
ILE A1147
GLY A1100
ALA A1099
ILE A 959
VAL A1127
 None
 1.08A 4nkxB-1rpmA:
undetectable		 4nkxB-1rpmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		3 / 3 ASN A 950
ASP A 952
ASP A 936
 None
 0.85A 4obwD-1rpmA:
undetectable		 4obwD-1rpmA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		5 / 12 VAL A1107
LEU A1156
LEU A1074
ALA A1154
ALA A1070
 None
 1.05A 4x1kA-1rpmA:
undetectable
4x1kB-1rpmA:
undetectable		 4x1kA-1rpmA:
20.96
4x1kB-1rpmA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		5 / 12 GLY A1075
GLY A1072
THR A1071
PHE A1105
ILE A1108
 None
 1.26A 4zvmA-1rpmA:
undetectable
4zvmB-1rpmA:
undetectable		 4zvmA-1rpmA:
21.85
4zvmB-1rpmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens) 		4 / 7 ASP A1113
ASP A1109
TYR A 968
GLY A 961
 None
 0.98A 5hwaA-1rpmA:
undetectable		 5hwaA-1rpmA:
21.93