SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 8 LEU A 177
SER A 127
PHE A 130
GLY A 131
NDP  A1501 (-4.7A)
None
None
None
0.67A 1fapB-1rpnA:
undetectable
1fapB-1rpnA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 VAL A   7
GLY A  31
TYR A  55
GLY A  15
MET A  60
None
None
None
None
NDP  A1501 (-4.8A)
1.24A 1fduC-1rpnA:
18.0
1fduC-1rpnA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 8 ARG A  45
ALA A  19
GLY A   9
ILE A  53
None
None
NDP  A1501 (-3.3A)
None
0.72A 1hshD-1rpnA:
undetectable
1hshD-1rpnA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 11 LEU A 286
GLU A 282
VAL A 283
GLU A 181
TRP A 220
None
GDP  A1601 (-2.6A)
None
NDP  A1501 ( 4.7A)
None
1.17A 1mrqA-1rpnA:
undetectable
1mrqA-1rpnA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 8 ARG A 218
GLY A 212
VAL A 214
ILE A 273
GDP  A1601 (-3.0A)
GDP  A1601 (-3.3A)
None
None
0.79A 1pk7B-1rpnA:
3.2
1pk7B-1rpnA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 LEU A   6
LEU A  81
MET A  60
None
NDP  A1501 (-4.1A)
NDP  A1501 (-4.8A)
0.67A 1ya3B-1rpnA:
undetectable
1ya3B-1rpnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 7 LEU A 108
ILE A  71
PRO A  75
VAL A  78
ILE A 112
None
1.36A 2aojB-1rpnA:
undetectable
2aojB-1rpnA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 104
ASP A  59
GLY A   9
VAL A  70
VAL A  66
None
NDP  A1501 (-2.9A)
NDP  A1501 (-3.3A)
None
None
0.93A 2nnkB-1rpnA:
undetectable
2nnkB-1rpnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 8 MET A  60
VAL A  66
PHE A 121
ASN A  80
NDP  A1501 (-4.8A)
None
None
None
1.04A 2wekA-1rpnA:
6.2
2wekA-1rpnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 8 MET A  60
VAL A  66
PHE A 121
ASN A  80
NDP  A1501 (-4.8A)
None
None
None
1.01A 2wekB-1rpnA:
6.3
2wekB-1rpnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 LEU A  47
ARG A  43
ILE A  49
None
NDP  A1501 ( 4.1A)
None
0.66A 2xn5B-1rpnA:
undetectable
2xn5B-1rpnA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 7 ASN A 213
GLY A 212
VAL A 190
ASP A 274
None
GDP  A1601 (-3.3A)
GDP  A1601 (-3.7A)
None
0.90A 2y05A-1rpnA:
5.3
2y05B-1rpnA:
5.6
2y05A-1rpnA:
21.98
2y05B-1rpnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 MET A 255
VAL A 313
GLU A 261
None
0.71A 3c6gA-1rpnA:
undetectable
3c6gA-1rpnA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 THR A  40
VAL A   7
LEU A  18
ILE A  10
TYR A  55
NDP  A1501 ( 4.1A)
None
None
None
None
1.46A 3elzC-1rpnA:
undetectable
3elzC-1rpnA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 ASP A 240
ARG A 165
ARG A 295
None
0.99A 3k37A-1rpnA:
undetectable
3k37A-1rpnA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 GLU A 128
LEU A 286
LEU A 305
GDP  A1601 (-3.7A)
None
None
0.77A 3ohtB-1rpnA:
undetectable
3ohtB-1rpnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 LEU A   6
TYR A  79
ALA A  19
GLY A  15
GLY A  31
None
1.12A 3ou7A-1rpnA:
3.8
3ou7A-1rpnA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 LEU A   6
TYR A  79
ALA A  19
GLY A  15
GLY A  31
None
1.15A 3ou7D-1rpnA:
3.7
3ou7D-1rpnA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLN A 123
LEU A 108
MET A  60
ALA A  82
ALA A 124
None
None
NDP  A1501 (-4.8A)
NDP  A1501 (-3.5A)
NDP  A1501 (-3.0A)
1.14A 3ut5D-1rpnA:
6.5
3ut5D-1rpnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 LEU A 132
GLY A 131
LEU A 286
ILE A 176
VAL A 243
None
1.13A 4ok1A-1rpnA:
0.0
4ok1A-1rpnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 5 TYR A  79
GLU A  77
LEU A  22
GLN A 235
None
1.43A 4qztB-1rpnA:
0.0
4qztB-1rpnA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 5 LEU A  21
GLU A  77
MET A 233
LEU A 297
None
1.27A 4xi3B-1rpnA:
undetectable
4xi3B-1rpnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
GDP  A1601 (-3.3A)
None
None
None
None
0.90A 5ehgA-1rpnA:
4.4
5ehgA-1rpnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 ASN A  80
ASP A  59
GLY A  58
None
NDP  A1501 (-2.9A)
None
0.62A 5fctB-1rpnA:
undetectable
5fctB-1rpnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 LEU A  32
LEU A 108
ARG A   3
None
0.61A 5hnzB-1rpnA:
7.3
5hnzB-1rpnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 ILE A 160
GLY A 157
THR A 126
SER A 125
LEU A 108
None
None
NDP  A1501 (-4.0A)
None
None
1.10A 5nfjB-1rpnA:
2.1
5nfjB-1rpnA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 ILE A 160
GLY A 157
THR A 126
SER A 125
LEU A 108
None
None
NDP  A1501 (-4.0A)
None
None
1.11A 5nfjC-1rpnA:
2.2
5nfjC-1rpnA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 ILE A 258
SER A 321
ARG A 319
ALA A 315
ALA A 199
None
1.06A 5oy02-1rpnA:
undetectable
5oy02-1rpnA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 7 THR A   8
PHE A 121
GLN A 123
MET A  60
None
None
None
NDP  A1501 (-4.8A)
1.28A 5u6mB-1rpnA:
5.2
5u6mB-1rpnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
4 / 6 ASN A  80
ALA A 124
VAL A 105
TYR A 122
None
NDP  A1501 (-3.0A)
None
None
1.22A 5umd2-1rpnA:
undetectable
5umdF-1rpnA:
undetectable
5umd2-1rpnA:
12.54
5umdF-1rpnA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
GDP  A1601 (-3.3A)
None
None
None
None
0.91A 5wz1A-1rpnA:
4.7
5wz1A-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
GDP  A1601 (-3.3A)
None
None
None
None
0.96A 5wz1C-1rpnA:
4.4
5wz1C-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
GDP  A1601 (-3.3A)
None
None
None
None
0.91A 5wz1D-1rpnA:
4.4
5wz1D-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
GDP  A1601 (-3.3A)
None
None
None
None
0.90A 5wz1F-1rpnA:
4.5
5wz1F-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
GDP  A1601 (-3.3A)
None
None
None
None
0.92A 5wz1G-1rpnA:
undetectable
5wz1G-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 212
ASP A 215
VAL A 214
ASP A 274
ILE A 273
GDP  A1601 (-3.3A)
None
None
None
None
0.95A 5wz1H-1rpnA:
4.5
5wz1H-1rpnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa)
3 / 3 TYR A  55
ALA A  19
LEU A  44
None
0.64A 6d9kF-1rpnA:
2.2
6d9kF-1rpnA:
18.38