SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 12 PHE A  21
LEU A 177
MET A 200
ALA A 195
ASP A  24
 None
 1.00A 1a4lB-1rptA:
undetectable		 1a4lB-1rptA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 11 GLY A  16
PRO A  17
HIS A 257
GLN A  37
LEU A  81
 None
None
VO4  A 343 (-3.8A)
None
None
 1.21A 1jzsA-1rptA:
undetectable		 1jzsA-1rptA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 12 TYR A 298
ASP A 289
SER A 318
HIS A 317
LEU A 312
 None
 1.24A 1kiaD-1rptA:
undetectable		 1kiaD-1rptA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 8 LEU A 231
ALA A 267
HIS A 282
MET A 284
 None
 1.08A 2wekA-1rptA:
undetectable		 2wekA-1rptA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 5 PHE A   5
PHE A  60
LEU A  61
PHE A  92
 None
 1.37A 3abmP-1rptA:
0.0
3abmW-1rptA:
0.0		 3abmP-1rptA:
20.41
3abmW-1rptA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 6 HIS A 282
THR A   7
LEU A 264
LEU A 231
 None
 1.19A 3bgdA-1rptA:
undetectable		 3bgdA-1rptA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 12 VAL A 331
ALA A 337
ASP A 128
PHE A 126
ASN A 233
 None
 1.29A 3qowA-1rptA:
undetectable		 3qowA-1rptA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 6 LEU A 251
ALA A 248
ARG A 249
LEU A  61
 None
 1.04A 3ravA-1rptA:
undetectable		 3ravA-1rptA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		3 / 3 PRO A 180
ASP A 179
GLU A  19
 None
 0.78A 3v4tC-1rptA:
undetectable		 3v4tC-1rptA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		3 / 3 TYR A 123
MET A 266
LEU A 211
 None
 0.99A 3vw1D-1rptA:
0.4		 3vw1D-1rptA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 7 PHE A  10
ALA A  84
ILE A 109
LEU A  91
 None
 0.87A 4uymA-1rptA:
0.0		 4uymA-1rptA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 7 PHE A  10
ALA A  84
ILE A 109
LEU A  91
 None
 0.86A 4uymB-1rptA:
0.4		 4uymB-1rptA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 6 ILE A 235
VAL A 295
PHE A   5
THR A 243
ARG A 249
 None
 1.48A 4xe5A-1rptA:
undetectable		 4xe5A-1rptA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 6 PRO A 307
LEU A  49
GLU A  48
TYR A  52
 None
 1.10A 4z4cA-1rptA:
undetectable		 4z4cA-1rptA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		4 / 8 ASN A 101
PRO A 102
SER A  98
TRP A 100
 None
 1.39A 5amiB-1rptA:
undetectable		 5amiB-1rptA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		3 / 3 TYR A 182
TYR A 299
SER A 280
 None
 0.96A 5iktB-1rptA:
undetectable		 5iktB-1rptA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 12 VAL A   9
LEU A 122
GLY A 228
SER A 224
PHE A 132
 None
 1.08A 5vooA-1rptA:
undetectable		 5vooA-1rptA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 12 VAL A   9
LEU A 122
GLY A 228
SER A 224
PHE A 132
 None
 1.10A 5vooC-1rptA:
undetectable		 5vooC-1rptA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		5 / 12 ALA A 199
THR A 193
PRO A 192
LEU A 206
PHE A 155
 None
 1.18A 5ybbA-1rptA:
undetectable		 5ybbA-1rptA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rpt PROSTATIC ACID
PHOSPHATASE
(Rattus
norvegicus) 		3 / 3 LEU A 312
ASN A 233
LEU A 264
 None
 0.54A 6exiA-1rptA:
undetectable		 6exiA-1rptA:
15.15