SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		5 / 12 THR A  89
ILE A 124
ALA A 153
ASN A 154
THR A 161
 None
 0.39A 1jtxA-1rpwA:
24.2		 1jtxA-1rpwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		5 / 12 TRP A  61
THR A  89
ILE A 124
ALA A 153
ASN A 154
 None
 0.91A 1jtxA-1rpwA:
24.2		 1jtxA-1rpwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 6 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.05A 1kiaA-1rpwA:
undetectable		 1kiaA-1rpwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 6 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.05A 1kiaB-1rpwA:
undetectable		 1kiaB-1rpwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 7 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.03A 1kiaC-1rpwA:
undetectable		 1kiaC-1rpwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 7 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.05A 1kiaD-1rpwA:
undetectable		 1kiaD-1rpwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 6 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.05A 1nbhA-1rpwA:
undetectable		 1nbhA-1rpwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 7 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.06A 1nbhB-1rpwA:
undetectable		 1nbhB-1rpwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 6 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.06A 1nbhC-1rpwA:
undetectable		 1nbhC-1rpwA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 7 TYR A 127
ASN A 157
TYR A  82
TYR A  93
 None
 1.05A 1nbhD-1rpwA:
undetectable		 1nbhD-1rpwA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 8 LEU A  54
GLU A  57
GLU A  58
TRP A  61
 None
 0.90A 1qvtA-1rpwA:
24.1		 1qvtA-1rpwA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 6 LEU A  54
GLU A  58
TRP A  61
THR A  89
 None
 1.08A 1qvuA-1rpwA:
24.3		 1qvuA-1rpwA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		8 / 12 GLU A  57
LYS A  60
TRP A  61
GLN A  64
TYR A  82
SER A  86
TYR A 127
VAL A 156
 None
None
None
SO4  A 189 (-3.6A)
None
None
None
None
 0.74A 1rkwA-1rpwA:
24.2		 1rkwA-1rpwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		8 / 12 GLU A  57
TRP A  61
GLN A  64
TYR A  82
SER A  86
THR A  89
TYR A 127
VAL A 156
 None
None
SO4  A 189 (-3.6A)
None
None
None
None
None
 0.87A 1rkwA-1rpwA:
24.2		 1rkwA-1rpwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		8 / 12 TRP A  61
GLN A  64
TYR A  82
SER A  86
THR A  89
TYR A 127
VAL A 156
ASN A 157
 None
SO4  A 189 (-3.6A)
None
None
None
None
None
None
 0.79A 1rkwA-1rpwA:
24.2		 1rkwA-1rpwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 7 TYR A 127
GLU A  68
THR A  89
VAL A 156
 None
 1.00A 1tv8A-1rpwA:
undetectable		 1tv8A-1rpwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 8 TYR A 127
GLU A  68
THR A  89
VAL A 156
 None
 1.05A 2fb2A-1rpwA:
undetectable		 2fb2A-1rpwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 7 TYR A 127
GLU A  68
THR A  89
VAL A 156
 None
 1.07A 2fb2B-1rpwA:
undetectable		 2fb2B-1rpwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 8 THR A 161
VAL A 160
ASN A  83
ALA A 153
 None
 1.15A 2ij7C-1rpwA:
0.0		 2ij7C-1rpwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 PHE A  79
GLN A  62
PHE A 178
 None
 0.70A 3rv5A-1rpwA:
undetectable		 3rv5A-1rpwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 PHE A 131
GLN A  62
PHE A 182
 None
 0.59A 3rv5A-1rpwA:
undetectable		 3rv5A-1rpwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		5 / 12 GLU A 101
ASN A  21
LEU A  14
ILE A  28
LEU A  39
 None
 1.43A 4k39A-1rpwA:
undetectable		 4k39A-1rpwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.70A 4k8cA-1rpwA:
undetectable		 4k8cA-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.69A 4kahA-1rpwA:
undetectable		 4kahA-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.70A 4kahB-1rpwA:
undetectable		 4kahB-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.71A 4kanA-1rpwA:
undetectable		 4kanA-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.72A 4kanB-1rpwA:
undetectable		 4kanB-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.73A 4kbeA-1rpwA:
undetectable		 4kbeA-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.71A 4kbeB-1rpwA:
undetectable		 4kbeB-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.69A 4lbgA-1rpwA:
undetectable		 4lbgA-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		3 / 3 SER A  86
TYR A  82
PRO A  94
 None
 0.69A 4lbgB-1rpwA:
undetectable		 4lbgB-1rpwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		5 / 12 PHE A 131
ALA A 152
TYR A  80
SER A 179
LEU A 183
 None
 1.23A 4qztC-1rpwA:
undetectable		 4qztC-1rpwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		5 / 12 GLY A  37
LEU A  39
SER A  34
VAL A  29
PHE A  43
 None
 1.12A 4wnwA-1rpwA:
0.0		 4wnwA-1rpwA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1rpw TRANSCRIPTIONAL
REGULATOR QACR
(Staphylococcus
aureus) 		4 / 6 GLY A 158
ILE A 130
TYR A  82
TYR A  92
 None
 1.08A 5iwuA-1rpwA:
undetectable		 5iwuA-1rpwA:
20.69