SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 9 LEU A 131
VAL A 137
ILE A 111
GLY A 122
ILE A 134
 None
 1.02A 1hpvA-1rpxA:
undetectable		 1hpvA-1rpxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		4 / 8 GLY A 189
VAL A 188
GLU A 160
ILE A 223
 None
 0.91A 1pk7B-1rpxA:
undetectable		 1pk7B-1rpxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 12 ILE A 111
GLY A 122
VAL A  44
PRO A  80
ILE A  77
 None
 1.09A 1zq9A-1rpxA:
undetectable		 1zq9A-1rpxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		3 / 3 HIS A  74
MET A 147
MET A  76
 None
 1.21A 2vj1A-1rpxA:
undetectable		 2vj1A-1rpxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 12 LEU A 125
ALA A 199
VAL A 196
VAL A 141
ILE A 134
 None
 1.12A 3czhB-1rpxA:
undetectable		 3czhB-1rpxA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 8 HIS A 108
VAL A 123
ILE A 111
VAL A 141
LEU A 138
 None
 1.09A 3kp6A-1rpxA:
undetectable
3kp6B-1rpxA:
undetectable		 3kp6A-1rpxA:
21.07
3kp6B-1rpxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		3 / 3 HIS A  74
HIS A  98
MET A  76
 None
 0.66A 3mihA-1rpxA:
undetectable		 3mihA-1rpxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		4 / 7 LEU A 169
ALA A 201
VAL A 188
ILE A 166
 None
 0.95A 3wsjB-1rpxA:
undetectable		 3wsjB-1rpxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		4 / 6 SER A  62
ASP A  61
THR A  67
ILE A  66
 None
 0.96A 4acbC-1rpxA:
2.5		 4acbC-1rpxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 12 GLY A 152
MET A  76
VAL A  44
HIS A  41
VAL A 205
 None
 1.16A 4okwA-1rpxA:
undetectable		 4okwA-1rpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 12 GLY A 152
MET A  45
VAL A  44
HIS A  41
VAL A 205
 None
 1.38A 4okxA-1rpxA:
undetectable		 4okxA-1rpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 12 GLY A 152
MET A  76
VAL A  44
HIS A  41
VAL A 205
 None
 1.16A 4okxA-1rpxA:
undetectable		 4okxA-1rpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		5 / 11 LEU A 143
GLY A 118
ILE A  94
ASP A  72
VAL A  73
 None
 1.20A 5hjiA-1rpxA:
undetectable		 5hjiA-1rpxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		3 / 3 TRP A  39
ILE A  40
ASP A  72
 None
 0.78A 6i0y7-1rpxA:
undetectable		 6i0y7-1rpxA:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1rpx PROTEIN
(RIBULOSE-PHOSPHATE
3-EPIMERASE)
(Solanum
tuberosum) 		3 / 3 ASP A 185
SER A 208
SER A  19
 None
SO4  A 231 (-3.2A)
SO4  A 231 ( 4.2A)
 0.69A 6mxtA-1rpxA:
undetectable		 6mxtA-1rpxA:
21.24