SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 281
PHE A 403
ILE A  62
ASN A  63
LEU A  59
 None
 1.12A 1dhfB-1rq1A:
undetectable		 1dhfB-1rq1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 281
PHE A 403
ILE A  62
ASN A  63
LEU A  59
 None
 1.11A 1dlsA-1rq1A:
undetectable		 1dlsA-1rq1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 276
LEU A 322
LEU A 373
LEU A 399
LEU A 282
 None
 1.24A 1g5yB-1rq1A:
undetectable		 1g5yB-1rq1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  78
LEU A 289
LEU A 396
ALA A 369
ILE A 372
 None
 1.06A 2bxpA-1rq1A:
undetectable		 2bxpA-1rq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 230
ARG A 356
GLY A 359
LYS A 360
 None
None
FAD  A 634 ( 4.6A)
None
 1.04A 2i30A-1rq1A:
1.0		 2i30A-1rq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 206
TYR A 224
PHE A 336
LEU A 226
 None
 1.13A 2w98A-1rq1A:
undetectable
2w98B-1rq1A:
undetectable		 2w98A-1rq1A:
22.36
2w98B-1rq1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 199
ARG A 356
GLY A 359
LYS A 360
 FAD  A 634 (-3.7A)
None
FAD  A 634 ( 4.6A)
None
 0.88A 3b9lA-1rq1A:
0.9		 3b9lA-1rq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 313
ALA A 276
VAL A 309
LEU A 400
PHE A 318
 None
 1.27A 3bszE-1rq1A:
undetectable		 3bszE-1rq1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 336
ALA A 222
SER A 217
PHE A 374
ALA A 369
 None
 1.33A 3lbdA-1rq1A:
undetectable		 3lbdA-1rq1A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 272
THR A 269
PHE A 273
LEU A 406
 None
 1.39A 3qelC-1rq1A:
undetectable		 3qelC-1rq1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 224
TYR A 204
ILE A 203
VAL A 227
ILE A 234
 None
FAD  A 634 (-4.7A)
None
None
FAD  A 634 (-4.0A)
 1.47A 3uprA-1rq1A:
undetectable		 3uprA-1rq1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 4 TRP A 113
LEU A 125
LEU A 243
THR A 245
 None
 1.47A 4bboD-1rq1A:
0.0		 4bboD-1rq1A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 372
THR A 368
ALA A 398
LEU A 399
THR A 402
 None
 1.15A 4g1bB-1rq1A:
undetectable		 4g1bB-1rq1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 8 THR A 402
LEU A 282
VAL A 388
LEU A 391
GLY A 365
 None
 1.37A 4r3aA-1rq1A:
undetectable		 4r3aA-1rq1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 165
LEU A 391
PHE A 145
LEU A 149
 None
 1.15A 5tl8A-1rq1A:
0.0		 5tl8A-1rq1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 224
TYR A 204
ILE A 203
VAL A 227
ILE A 234
 None
FAD  A 634 (-4.7A)
None
None
FAD  A 634 (-4.0A)
 1.44A 5u98A-1rq1A:
undetectable		 5u98A-1rq1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 400
ILE A 397
PHE A  78
SER A  76
LEU A 391
 None
 1.25A 5uanB-1rq1A:
0.5		 5uanB-1rq1A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  74
ARG A 405
GLU A 411
SER A 412
 None
CD  A 813 ( 4.6A)
None
None
 1.15A 5umwA-1rq1A:
undetectable
5umwF-1rq1A:
undetectable		 5umwA-1rq1A:
14.01
5umwF-1rq1A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 401
ALA A 398
GLU A 186
LEU A 181
ILE A 179
 None
None
FAD  A 634 (-4.6A)
None
None
 1.00A 5vlmG-1rq1A:
0.4		 5vlmG-1rq1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  68
ARG A  67
GLU A  64
GLU A 408
 None
None
None
CD  A 813 (-3.2A)
 1.29A 6mn4C-1rq1A:
undetectable		 6mn4C-1rq1A:
22.34