SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 ALA A 324
GLU A 325
VAL A 363
MET A 364
 None
 0.64A 1hk2A-1rqbA:
undetectable		 1hk2A-1rqbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 HIS A 217
LEU A  28
SER A  27
ASP A  23
 CO  A 529 (-3.3A)
None
None
CO  A 529 (-2.5A)
 1.16A 1ismB-1rqbA:
undetectable		 1ismB-1rqbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 PHE A 111
TRP A  73
GLU A 437
 None
 1.16A 1mogA-1rqbA:
undetectable		 1mogA-1rqbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 ASP A  71
PHE A 452
ARG A 456
 None
 0.86A 2a3aA-1rqbA:
9.7		 2a3aA-1rqbA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		6 / 11 SER A 226
ALA A 195
GLY A 221
THR A 220
ASP A 185
CYH A 216
 None
 1.38A 2f16H-1rqbA:
undetectable
2f16I-1rqbA:
undetectable		 2f16H-1rqbA:
17.51
2f16I-1rqbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 8 TYR A 103
TYR A  61
PHE A 445
GLY A  57
 None
 1.11A 2ha4A-1rqbA:
undetectable		 2ha4A-1rqbA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 6 PRO A  72
LEU A  68
ARG A 456
GLY A 459
 None
 1.21A 2hs2B-1rqbA:
undetectable		 2hs2B-1rqbA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 ASP A  44
ASP A 280
ASP A 271
 None
 0.78A 2igtB-1rqbA:
undetectable		 2igtB-1rqbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		6 / 12 LEU A 183
SER A 218
ALA A 188
LEU A 227
LEU A 214
VAL A 238
 KCX  A 184 ( 4.0A)
None
None
None
None
None
 1.49A 3adxB-1rqbA:
undetectable		 3adxB-1rqbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 12 LEU A 214
ALA A 182
ILE A 198
ALA A 230
ASP A 239
 None
 1.04A 3axtA-1rqbA:
undetectable		 3axtA-1rqbA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 GLY A 343
ILE A 354
VAL A 355
 None
 0.45A 3nv6A-1rqbA:
undetectable		 3nv6A-1rqbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 6 GLN A  89
HIS A 251
ARG A 124
HIS A 215
 None
None
None
CO  A 529 (-3.4A)
 1.18A 3nvcA-1rqbA:
undetectable		 3nvcA-1rqbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 6 GLU A 255
ILE A 242
HIS A 217
VAL A 298
 None
None
CO  A 529 (-3.3A)
None
 1.19A 4a97I-1rqbA:
0.0		 4a97I-1rqbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 6 GLY A  15
TRP A  51
ARG A 124
ARG A  87
 None
 1.31A 4bqfA-1rqbA:
undetectable		 4bqfA-1rqbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 6 THR A 254
GLU A  18
THR A 240
LEU A 270
 None
 0.84A 4pgfA-1rqbA:
undetectable		 4pgfA-1rqbA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		3 / 3 THR A 466
ASP A 467
ALA A 468
 None
 0.04A 5g5gB-1rqbA:
0.0		 5g5gB-1rqbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		5 / 12 ASP A 185
VAL A 238
VAL A 257
GLY A 221
THR A 220
 None
 1.23A 5igiA-1rqbA:
undetectable		 5igiA-1rqbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		6 / 12 ILE A  16
ALA A  24
VAL A  20
LEU A  28
GLY A 248
THR A 219
 None
 1.44A 5igtA-1rqbA:
undetectable		 5igtA-1rqbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 7 ILE A 302
PHE A 303
ASP A 185
SER A 226
 None
 1.30A 5nr3A-1rqbA:
undetectable		 5nr3A-1rqbA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1rqb TRANSCARBOXYLASE 5S
SUBUNIT
(Propionibacteriu
m
freudenreichii) 		4 / 9 HIS A 455
LEU A 444
VAL A 439
ASP A 438
 None
 0.92A 6c2mD-1rqbA:
undetectable		 6c2mD-1rqbA:
10.62