SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 ALA A 352
LEU A 340
LEU A  22
ALA A  23
PHE A 358
 None
 0.89A 1g5yB-1rqgA:
undetectable		 1g5yB-1rqgA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 ILE A 262
GLU A 321
LYS A 279
ILE A 266
PHE A 107
 None
 1.36A 1gx9A-1rqgA:
undetectable		 1gx9A-1rqgA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 PRO A  11
PRO A  16
GLY A  15
PHE A  82
THR A  49
 None
 1.40A 1h4oC-1rqgA:
2.6
1h4oD-1rqgA:
3.0		 1h4oC-1rqgA:
14.37
1h4oD-1rqgA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 PRO A  11
PRO A  16
GLY A  15
PHE A  82
THR A  49
 None
 1.40A 1h4oE-1rqgA:
3.0
1h4oF-1rqgA:
3.1		 1h4oE-1rqgA:
14.37
1h4oF-1rqgA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 PRO A  11
PRO A  16
GLY A  15
PHE A  82
THR A  49
 None
 1.39A 1h4oH-1rqgA:
0.0		 1h4oH-1rqgA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 PHE A 465
ALA A 463
LEU A 396
LEU A 456
LEU A 400
 None
 1.25A 1jipA-1rqgA:
2.2		 1jipA-1rqgA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		6 / 11 ALA A   9
HIS A  18
GLY A  20
HIS A  21
GLY A 296
TYR A 337
 None
 0.63A 1pg2A-1rqgA:
36.5		 1pg2A-1rqgA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		6 / 11 HIS A  18
GLY A  20
HIS A  21
GLY A 296
ASP A 298
TYR A 337
 None
 0.98A 1pg2A-1rqgA:
36.5		 1pg2A-1rqgA:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 GLY A 501
ALA A 499
LEU A 500
PHE A 440
LEU A 462
 None
 1.40A 1y7iA-1rqgA:
undetectable		 1y7iA-1rqgA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 340
ILE A 353
PHE A 556
GLY A 564
PHE A 385
 None
 1.01A 1zz1B-1rqgA:
undetectable
1zz1C-1rqgA:
undetectable		 1zz1B-1rqgA:
19.11
1zz1C-1rqgA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 LEU A 508
LEU A 504
LEU A 456
LEU A  27
 None
 0.97A 2ab2A-1rqgA:
undetectable		 2ab2A-1rqgA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 HIS A  21
PHE A  82
PHE A 294
ALA A 334
PRO A  28
 None
 1.29A 2igtC-1rqgA:
undetectable		 2igtC-1rqgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 VAL A 355
MET A 375
PHE A  82
SER A   8
PHE A  45
 None
 1.48A 2ij7A-1rqgA:
0.0		 2ij7A-1rqgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 ALA A   9
HIS A  18
GLY A  20
HIS A  21
GLY A 296
 None
 0.68A 2x1lA-1rqgA:
33.0		 2x1lA-1rqgA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 HIS A  18
GLY A  20
HIS A  21
GLY A 296
ASP A 298
 None
 1.10A 2x1lA-1rqgA:
33.0		 2x1lA-1rqgA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		6 / 12 ALA A   9
HIS A  18
GLY A  20
HIS A  21
GLY A 296
LEU A 338
 None
 0.79A 2x1lB-1rqgA:
34.2		 2x1lB-1rqgA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		6 / 12 HIS A  18
GLY A  20
HIS A  21
GLY A 296
ASP A 298
LEU A 338
 None
 1.14A 2x1lB-1rqgA:
34.2		 2x1lB-1rqgA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 ALA A   9
HIS A  18
GLY A  20
HIS A  21
GLY A 296
 None
 0.69A 2x1lC-1rqgA:
34.2		 2x1lC-1rqgA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 HIS A  18
GLY A  20
HIS A  21
GLY A 296
ASP A 298
 None
 1.13A 2x1lC-1rqgA:
34.2		 2x1lC-1rqgA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 251
ALA A 257
GLY A 236
ILE A 259
SER A 104
 None
 1.28A 3gyqA-1rqgA:
undetectable
3gyqB-1rqgA:
undetectable		 3gyqA-1rqgA:
16.62
3gyqB-1rqgA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 5 GLU A  51
LEU A  10
HIS A 100
GLY A 260
 None
 1.28A 3pp1A-1rqgA:
undetectable		 3pp1A-1rqgA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 5 GLU A  96
LEU A  97
HIS A  75
GLY A  93
 None
 1.03A 3pp1A-1rqgA:
undetectable		 3pp1A-1rqgA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 8 THR A  54
GLN A 155
VAL A 139
PRO A 165
 None
 0.98A 4e1vA-1rqgA:
undetectable		 4e1vA-1rqgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 8 THR A  54
GLN A 155
VAL A 139
PRO A 165
 None
 0.99A 4e1vC-1rqgA:
undetectable		 4e1vC-1rqgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 8 THR A  54
GLN A 155
VAL A 139
PRO A 165
 None
 1.00A 4e1vH-1rqgA:
undetectable		 4e1vH-1rqgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		3 / 3 ASP A  50
ARG A 231
THR A  95
 None
 0.79A 4i13A-1rqgA:
undetectable		 4i13A-1rqgA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 MET A 460
LEU A 508
ILE A 515
PHE A 403
GLY A 401
 None
 0.92A 4kukA-1rqgA:
undetectable		 4kukA-1rqgA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 GLY A  20
ALA A  19
ILE A  31
THR A  81
VAL A 355
 None
 0.98A 4l1aA-1rqgA:
undetectable		 4l1aA-1rqgA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		3 / 3 ASP A  50
ARG A 231
THR A  95
 None
 0.78A 4p3rA-1rqgA:
2.1		 4p3rA-1rqgA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 VAL A 497
LEU A 500
LEU A 519
GLY A 401
LEU A 408
 None
 1.06A 4rs0A-1rqgA:
2.1		 4rs0A-1rqgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 GLU A 256
PHE A 255
PHE A 107
HIS A 100
 None
 1.49A 4uciA-1rqgA:
1.6		 4uciA-1rqgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 7 GLU A 256
PHE A 255
PHE A 107
HIS A 100
 None
 1.47A 4uciB-1rqgA:
1.7		 4uciB-1rqgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 11 LEU A 400
LEU A 396
GLU A 505
LEU A 508
TYR A 369
 None
 1.12A 4wg0J-1rqgA:
undetectable
4wg0K-1rqgA:
undetectable
4wg0L-1rqgA:
undetectable		 4wg0J-1rqgA:
2.23
4wg0K-1rqgA:
2.23
4wg0L-1rqgA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		3 / 3 LYS A 279
ILE A 266
ILE A  99
 None
 0.66A 4y0qA-1rqgA:
undetectable		 4y0qA-1rqgA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 5 ALA A  85
HIS A 293
PRO A  11
PHE A  45
 None
 1.20A 4ze2A-1rqgA:
undetectable		 4ze2A-1rqgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 7 SER A 384
ASP A 574
ARG A 570
GLY A 568
GLU A 567
 None
 1.35A 5btaA-1rqgA:
0.0
5btaC-1rqgA:
0.0
5btaD-1rqgA:
2.7		 5btaA-1rqgA:
21.17
5btaC-1rqgA:
21.17
5btaD-1rqgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 7 SER A 386
ASP A 574
ARG A 570
GLY A 568
GLU A 567
 None
 1.22A 5btaA-1rqgA:
0.0
5btaC-1rqgA:
0.0
5btaD-1rqgA:
2.7		 5btaA-1rqgA:
21.17
5btaC-1rqgA:
21.17
5btaD-1rqgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 SER A 386
ARG A 570
GLY A 568
GLU A 567
 None
 0.82A 5btaA-1rqgA:
0.0
5btaB-1rqgA:
1.3
5btaC-1rqgA:
0.0		 5btaA-1rqgA:
21.17
5btaB-1rqgA:
17.69
5btaC-1rqgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 SER A 384
ARG A 570
GLY A 568
GLU A 567
 None
 1.05A 5btcA-1rqgA:
0.0
5btcC-1rqgA:
0.0
5btcD-1rqgA:
2.6		 5btcA-1rqgA:
21.17
5btcC-1rqgA:
21.17
5btcD-1rqgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 SER A 386
ARG A 570
GLY A 568
GLU A 567
 None
 0.87A 5btcA-1rqgA:
0.0
5btcC-1rqgA:
0.0
5btcD-1rqgA:
2.6		 5btcA-1rqgA:
21.17
5btcC-1rqgA:
21.17
5btcD-1rqgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 SER A 384
ARG A 570
GLY A 568
GLU A 567
 None
 1.05A 5btcA-1rqgA:
0.0
5btcB-1rqgA:
1.4
5btcC-1rqgA:
0.0		 5btcA-1rqgA:
21.17
5btcB-1rqgA:
17.69
5btcC-1rqgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 SER A 386
ARG A 570
GLY A 568
GLU A 567
 None
 0.84A 5btcA-1rqgA:
0.0
5btcB-1rqgA:
1.4
5btcC-1rqgA:
0.0		 5btcA-1rqgA:
21.17
5btcB-1rqgA:
17.69
5btcC-1rqgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 7 SER A 386
ASP A 574
ARG A 570
GLY A 568
GLU A 567
 None
 1.22A 5btfA-1rqgA:
0.0
5btfB-1rqgA:
2.5
5btfC-1rqgA:
0.0		 5btfA-1rqgA:
21.17
5btfB-1rqgA:
17.69
5btfC-1rqgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 7 SER A 386
ASP A 574
ARG A 570
GLU A 567
 None
 1.03A 5btfA-1rqgA:
0.0
5btfC-1rqgA:
0.0
5btfD-1rqgA:
2.7		 5btfA-1rqgA:
21.17
5btfC-1rqgA:
21.17
5btfD-1rqgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 ILE A 392
THR A 372
GLN A 552
LEU A 367
LEU A  27
 None
 1.42A 5fhzB-1rqgA:
3.1		 5fhzB-1rqgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 9 THR A 372
LEU A 508
GLN A 552
LEU A 367
LEU A  27
 None
 1.44A 5fhzB-1rqgA:
3.1		 5fhzB-1rqgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 HIS A  18
GLY A  20
HIS A  21
GLY A 296
ASP A 298
 None
 0.98A 5hg0B-1rqgA:
5.7		 5hg0B-1rqgA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 HIS A  18
GLY A  20
HIS A  21
VAL A 253
GLY A 296
 None
 0.90A 5hg0B-1rqgA:
5.7		 5hg0B-1rqgA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 GLU A 222
GLY A 223
PHE A 306
ARG A 227
 None
 1.19A 5jcnB-1rqgA:
2.3		 5jcnB-1rqgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 7 LEU A 199
ILE A 300
LYS A 213
VAL A 216
 None
 1.03A 5jh7C-1rqgA:
undetectable		 5jh7C-1rqgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 10 HIS A 293
HIS A 303
LEU A  10
ALA A   9
PRO A  11
 None
 1.34A 5tt3C-1rqgA:
undetectable		 5tt3C-1rqgA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 GLU A 505
ARG A  34
GLY A 501
SER A 512
ILE A 502
 None
 1.11A 5vooA-1rqgA:
2.6		 5vooA-1rqgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 GLU A 505
ARG A  34
GLY A 501
SER A 512
ILE A 502
 None
 1.13A 5vooB-1rqgA:
undetectable		 5vooB-1rqgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 12 GLU A 505
ARG A  34
GLY A 501
SER A 512
ILE A 502
 None
 1.14A 5vooC-1rqgA:
undetectable		 5vooC-1rqgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		4 / 6 LEU A 544
VAL A 404
LEU A 408
VAL A 497
 None
 0.94A 5x7zA-1rqgA:
undetectable		 5x7zA-1rqgA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		3 / 3 GLY A  93
THR A  49
GLU A  51
 None
 0.60A 6b58A-1rqgA:
6.1		 6b58A-1rqgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 10 ASN A 449
ARG A 451
GLU A 377
GLY A 444
ILE A  31
 None
 1.08A 6bniA-1rqgA:
undetectable		 6bniA-1rqgA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		5 / 10 ASN A 449
ARG A 451
GLU A 377
GLY A 444
ILE A  31
 None
 1.12A 6bniB-1rqgA:
undetectable		 6bniB-1rqgA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		3 / 3 TRP A 278
GLU A 277
GLU A 321
 None
 0.98A 6fhwA-1rqgA:
2.6		 6fhwA-1rqgA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rqg METHIONYL-TRNA
SYNTHETASE
(Pyrococcus
abyssi) 		3 / 3 ARG A  37
PHE A 507
PHE A  45
 None
 1.07A 6nknC-1rqgA:
3.7
6nknJ-1rqgA:
0.0		 6nknC-1rqgA:
15.21
6nknJ-1rqgA:
6.40