SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 12 ALA A 725
ILE A 736
PRO A 737
ASN A 740
LEU A 744
 None
 0.97A 1dlsA-1rr9A:
undetectable		 1dlsA-1rr9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 8 ALA A 602
ILE A 716
GLY A 717
GLY A 718
ALA A 726
 None
 1.19A 1sguA-1rr9A:
undetectable		 1sguA-1rr9A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 9 GLY A 681
TYR A 626
ALA A 640
LEU A 624
LEU A 709
 None
 1.08A 2npnA-1rr9A:
undetectable		 2npnA-1rr9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 8 ALA A 770
LEU A 771
CYH A 685
ILE A 763
ILE A 654
 None
 1.37A 2uxpA-1rr9A:
undetectable		 2uxpA-1rr9A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		4 / 5 VAL A 645
VAL A 644
THR A 615
ARG A 648
 None
 1.07A 3bjwC-1rr9A:
undetectable		 3bjwC-1rr9A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		4 / 8 ILE A 747
PRO A 759
HIS A 758
VAL A 734
 None
 0.87A 3em0B-1rr9A:
undetectable		 3em0B-1rr9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 12 LEU A 767
ALA A 770
LEU A 735
ILE A 707
GLY A 681
 None
 1.01A 3q95A-1rr9A:
undetectable		 3q95A-1rr9A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 12 LEU A 767
ALA A 770
LEU A 735
ILE A 707
GLY A 681
 None
 1.01A 3q95B-1rr9A:
undetectable		 3q95B-1rr9A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 12 ALA A 725
ILE A 736
PRO A 737
ASN A 740
LEU A 744
 None
 0.91A 4gh8A-1rr9A:
undetectable		 4gh8A-1rr9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 12 LEU A 630
GLN A 597
MET A 634
ILE A 638
ALA A 641
 None
 1.06A 4ltwA-1rr9A:
undetectable		 4ltwA-1rr9A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		8 / 12 LEU A 611
MET A 634
THR A 673
LYS A 675
GLY A 677
PRO A 678
ALA A 680
LYS A 722
 None
 0.77A 4ypmA-1rr9A:
29.4		 4ypmA-1rr9A:
38.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		4 / 8 ILE A 664
ALA A 641
VAL A 645
VAL A 666
 None
 0.79A 5ecnD-1rr9A:
undetectable		 5ecnD-1rr9A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		5 / 12 GLY A 717
GLY A 631
VAL A 633
GLY A 607
GLY A 608
 None
 0.93A 5koxA-1rr9A:
undetectable		 5koxA-1rr9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1rr9 ATP-DEPENDENT
PROTEASE LA
(Escherichia
coli) 		4 / 7 VAL A 734
ILE A 682
GLY A 631
ALA A 602
 None
 0.82A 6hd6B-1rr9A:
undetectable		 6hd6B-1rr9A:
17.68