SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rrc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 9 LEU A 240
ALA A 201
VAL A 162
VAL A 209
ILE A 207
 None
 0.97A 2o4pB-1rrcA:
undetectable		 2o4pB-1rrcA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		3 / 3 LEU A 196
TYR A 200
GLY A 204
 None
 0.57A 2ocuA-1rrcA:
undetectable		 2ocuA-1rrcA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		3 / 3 ASP A  35
ASN A  33
THR A  67
 None
 0.80A 2q63B-1rrcA:
undetectable		 2q63B-1rrcA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		3 / 3 VAL A 193
SER A 197
LEU A 170
 None
 0.67A 3n8xA-1rrcA:
undetectable		 3n8xA-1rrcA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		4 / 7 ASP A 278
GLY A 212
THR A 169
LYS A 258
 CA  A 700 (-3.1A)
None
None
CA  A 700 ( 4.7A)
 1.03A 3vnsA-1rrcA:
3.2		 3vnsA-1rrcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		3 / 3 ASP A  85
VAL A 111
ASN A  31
 None
 0.58A 4lmnA-1rrcA:
undetectable		 4lmnA-1rrcA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		3 / 3 ASP A 167
GLY A 212
ASP A 254
 None
 0.61A 4xdtA-1rrcA:
undetectable		 4xdtA-1rrcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 12 VAL A 209
LEU A 170
THR A 169
VAL A 238
PRO A 239
 None
 1.03A 4xiwB-1rrcA:
undetectable
4xiwE-1rrcA:
undetectable		 4xiwB-1rrcA:
22.08
4xiwE-1rrcA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		4 / 7 ASP A 278
GLY A 212
THR A 169
LYS A 258
 CA  A 700 (-3.1A)
None
None
CA  A 700 ( 4.7A)
 0.99A 4zxiA-1rrcA:
4.7		 4zxiA-1rrcA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 10 GLY A 290
ALA A 275
VAL A 291
GLU A 292
ILE A 289
 None
 1.01A 5i3cB-1rrcA:
2.1		 5i3cB-1rrcA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 12 VAL A 256
ASP A 255
GLU A 259
ARG A 288
LEU A 147
 None
CA  A 701 ( 4.1A)
None
CA  A 701 ( 4.4A)
None
 0.97A 5m50B-1rrcA:
3.2		 5m50B-1rrcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 12 VAL A 256
ASP A 255
GLU A 259
ARG A 288
LEU A 147
 None
CA  A 701 ( 4.1A)
None
CA  A 701 ( 4.4A)
None
 0.91A 5m50E-1rrcA:
3.6		 5m50E-1rrcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 12 VAL A 256
ASP A 255
GLU A 259
ARG A 288
LEU A 147
 None
CA  A 701 ( 4.1A)
None
CA  A 701 ( 4.4A)
None
 0.82A 5m5cB-1rrcA:
2.5		 5m5cB-1rrcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1rrc POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		4 / 5 GLY A 168
ASP A 278
ARG A 279
GLN A 245
 CA  A 700 ( 4.6A)
CA  A 700 (-3.1A)
None
None
 1.31A 5zrfB-1rrcA:
undetectable		 5zrfB-1rrcA:
16.94