SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rrh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 4 HIS A 709
LEU A 277
LEU A 560
LEU A 258
 FE2  A 858 ( 3.4A)
None
None
None
 1.13A 1a4lD-1rrhA:
undetectable		 1a4lD-1rrhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 4 VAL A 280
PHE A 335
SER A 768
VAL A 769
 None
 1.43A 1e7cA-1rrhA:
2.7		 1e7cA-1rrhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 THR A  30
ASN A  27
ASP A  25
GLU A 197
 None
 1.20A 1mxgA-1rrhA:
undetectable		 1mxgA-1rrhA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 THR A 575
THR A 728
SER A 510
VAL A 372
 None
 1.16A 1tv8A-1rrhA:
undetectable		 1tv8A-1rrhA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 748
LEU A 745
ALA A 752
LEU A 499
MET A 359
 None
 1.15A 1ya3A-1rrhA:
undetectable		 1ya3A-1rrhA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 PHE A  53
GLU A  83
GLY A  84
THR A  80
 None
 1.06A 1ykiA-1rrhA:
0.0
1ykiB-1rrhA:
undetectable		 1ykiA-1rrhA:
14.00
1ykiB-1rrhA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 THR A  80
PHE A  53
GLU A  83
GLY A  84
 None
 1.07A 1ykiA-1rrhA:
undetectable
1ykiB-1rrhA:
undetectable		 1ykiA-1rrhA:
14.00
1ykiB-1rrhA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 PHE A  53
GLU A  83
GLY A  84
THR A  80
 None
 1.05A 1ykiC-1rrhA:
undetectable
1ykiD-1rrhA:
0.0		 1ykiC-1rrhA:
14.00
1ykiD-1rrhA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 THR A  80
PHE A  53
GLU A  83
GLY A  84
 None
 1.03A 1ykiC-1rrhA:
undetectable
1ykiD-1rrhA:
0.0		 1ykiC-1rrhA:
14.00
1ykiD-1rrhA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 748
LEU A 745
ALA A 752
LEU A 499
MET A 359
 None
 1.21A 2aa5A-1rrhA:
undetectable		 2aa5A-1rrhA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 748
LEU A 745
ALA A 752
LEU A 499
MET A 359
 None
 1.19A 2aa6A-1rrhA:
undetectable		 2aa6A-1rrhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 748
LEU A 745
ALA A 752
LEU A 499
MET A 359
 None
 1.19A 2aa6B-1rrhA:
undetectable		 2aa6B-1rrhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 4 VAL A 571
LEU A 343
ILE A 325
LEU A 331
 None
 0.95A 2byoA-1rrhA:
undetectable		 2byoA-1rrhA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 THR A 792
PRO A 542
TYR A 647
 None
 0.97A 2dxrA-1rrhA:
undetectable		 2dxrA-1rrhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 THR A 575
THR A 728
SER A 510
VAL A 372
 None
 1.13A 2fb2A-1rrhA:
undetectable		 2fb2A-1rrhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 THR A 575
THR A 728
SER A 510
VAL A 372
 None
 1.16A 2fb2B-1rrhA:
undetectable		 2fb2B-1rrhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 VAL A 525
TRP A 703
TRP A 593
PHE A 595
 None
 1.28A 2g6hA-1rrhA:
undetectable
2g6hB-1rrhA:
undetectable		 2g6hA-1rrhA:
18.99
2g6hB-1rrhA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 SER A 470
SER A 483
VAL A 485
LEU A 380
 None
 0.96A 2hdnE-1rrhA:
undetectable
2hdnF-1rrhA:
undetectable
2hdnH-1rrhA:
undetectable		 2hdnE-1rrhA:
3.83
2hdnF-1rrhA:
17.46
2hdnH-1rrhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 SER A 483
VAL A 485
LEU A 380
SER A 470
 None
 0.90A 2hdnF-1rrhA:
undetectable
2hdnG-1rrhA:
undetectable
2hdnH-1rrhA:
undetectable		 2hdnF-1rrhA:
17.46
2hdnG-1rrhA:
3.83
2hdnH-1rrhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 5 PRO A 759
PHE A 292
PHE A 761
ILE A 315
 None
 1.13A 2hjhA-1rrhA:
undetectable		 2hjhA-1rrhA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 11 HIS A 709
ASN A 853
VAL A 781
ILE A 857
ALA A 777
 FE2  A 858 ( 3.4A)
None
None
None
None
 1.48A 2iyfA-1rrhA:
undetectable		 2iyfA-1rrhA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 GLY A 720
LEU A 722
ASP A 766
LEU A 773
SER A 774
 None
 1.31A 2nv4A-1rrhA:
0.0		 2nv4A-1rrhA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 GLY A 720
LEU A 722
ASP A 766
LEU A 773
SER A 774
 None
 1.32A 2nv4B-1rrhA:
0.0		 2nv4B-1rrhA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 6 TYR A 311
TYR A 717
GLN A 716
ILE A 770
 None
 1.39A 2pgzD-1rrhA:
undetectable
2pgzE-1rrhA:
undetectable		 2pgzD-1rrhA:
12.84
2pgzE-1rrhA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 PRO A 834
ASN A 819
ARG A 827
 None
 0.90A 2qeuB-1rrhA:
0.0		 2qeuB-1rrhA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 11 SER A 841
ILE A 636
GLY A 784
SER A 816
LEU A 839
 None
 0.95A 2qmmA-1rrhA:
undetectable
2qmmB-1rrhA:
undetectable		 2qmmA-1rrhA:
18.07
2qmmB-1rrhA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 11 LEU A 546
ILE A 701
ALA A 697
GLU A 670
LEU A 664
 None
 1.36A 2v0mA-1rrhA:
0.0		 2v0mA-1rrhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 ALA A 174
ALA A  68
GLY A 110
ALA A  65
 None
 0.89A 2vh3B-1rrhA:
0.1		 2vh3B-1rrhA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 6 VAL A 516
ASP A 509
HIS A 429
ASN A 521
 None
 1.38A 2zs9A-1rrhA:
undetectable		 2zs9A-1rrhA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.00A 3ag2C-1rrhA:
0.4		 3ag2C-1rrhA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 0.99A 3ag2P-1rrhA:
undetectable
3ag2W-1rrhA:
undetectable		 3ag2P-1rrhA:
15.87
3ag2W-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 LEU A 745
TRP A 498
TYR A 753
 None
 0.88A 3aicA-1rrhA:
undetectable		 3aicA-1rrhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 LEU A 745
TRP A 498
TYR A 753
 None
 0.91A 3aicB-1rrhA:
undetectable		 3aicB-1rrhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 LEU A 745
TRP A 498
TYR A 753
 None
 0.91A 3aicE-1rrhA:
undetectable		 3aicE-1rrhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 LEU A 745
TRP A 498
TYR A 753
 None
 0.88A 3aicF-1rrhA:
undetectable		 3aicF-1rrhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 LEU A 745
TRP A 498
TYR A 753
 None
 0.93A 3aicG-1rrhA:
undetectable		 3aicG-1rrhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 LEU A 745
TRP A 498
TYR A 753
 None
 0.92A 3aicH-1rrhA:
undetectable		 3aicH-1rrhA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.04A 3asnP-1rrhA:
0.4
3asnW-1rrhA:
undetectable		 3asnP-1rrhA:
15.87
3asnW-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.00A 3asoP-1rrhA:
0.4
3asoW-1rrhA:
undetectable		 3asoP-1rrhA:
15.87
3asoW-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 TRP A 703
TRP A 593
PHE A 595
VAL A 525
 None
 1.16A 3b3pA-1rrhA:
undetectable
3b3pB-1rrhA:
2.3		 3b3pA-1rrhA:
18.84
3b3pB-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 375
ASN A 373
ILE A 851
GLY A 850
LEU A 708
 None
 1.08A 3eeyA-1rrhA:
undetectable		 3eeyA-1rrhA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 375
ASN A 373
ILE A 851
GLY A 850
LEU A 708
 None
 1.07A 3eeyB-1rrhA:
undetectable		 3eeyB-1rrhA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 375
ASN A 373
ILE A 851
GLY A 850
LEU A 708
 None
 1.12A 3eeyH-1rrhA:
undetectable		 3eeyH-1rrhA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ASN A 375
ASN A 373
ILE A 851
GLY A 850
LEU A 708
 None
 1.10A 3eeyI-1rrhA:
undetectable		 3eeyI-1rrhA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 11 ILE A  12
ILE A 111
ASN A 164
ILE A 141
SER A 140
 None
 1.14A 3kpcA-1rrhA:
undetectable		 3kpcA-1rrhA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.26A 3n62A-1rrhA:
undetectable		 3n62A-1rrhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.29A 3n66B-1rrhA:
0.0		 3n66B-1rrhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 5 ARG A 237
THR A 238
ASP A 205
GLU A 250
 None
 1.13A 3v5vC-1rrhA:
0.0
3v5vD-1rrhA:
0.0		 3v5vC-1rrhA:
19.33
3v5vD-1rrhA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 LEU A 328
VAL A 284
LEU A 288
ILE A 315
LEU A 310
 None
 1.07A 3w67D-1rrhA:
undetectable		 3w67D-1rrhA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 PHE A 345
VAL A 284
LEU A 288
ILE A 315
LEU A 310
 None
 1.20A 3w67D-1rrhA:
undetectable		 3w67D-1rrhA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 GLN A 514
HIS A 518
HIS A 709
HIS A 523
 None
FE2  A 858 ( 3.4A)
FE2  A 858 ( 3.4A)
FE2  A 858 ( 3.3A)
 0.73A 3w6hA-1rrhA:
undetectable		 3w6hA-1rrhA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 6 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.04A 3wg7C-1rrhA:
undetectable
3wg7J-1rrhA:
undetectable		 3wg7C-1rrhA:
15.87
3wg7J-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 6 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.05A 3wg7P-1rrhA:
1.3
3wg7W-1rrhA:
undetectable		 3wg7P-1rrhA:
15.87
3wg7W-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 0.97A 3x2qP-1rrhA:
undetectable
3x2qW-1rrhA:
0.0		 3x2qP-1rrhA:
15.87
3x2qW-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 PHE A  53
VAL A  58
ILE A 117
ASN A 119
 None
 1.07A 4a97D-1rrhA:
undetectable		 4a97D-1rrhA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 PHE A  53
VAL A  58
ILE A 117
ASN A 119
 None
 1.09A 4a97G-1rrhA:
undetectable		 4a97G-1rrhA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 PHE A  53
VAL A  58
ILE A 117
ASN A 119
 None
 1.14A 4a97H-1rrhA:
undetectable		 4a97H-1rrhA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 5 GLU A 250
ARG A 237
THR A 238
ASP A 205
 None
 1.15A 4e7cA-1rrhA:
0.0
4e7cB-1rrhA:
0.0		 4e7cA-1rrhA:
19.21
4e7cB-1rrhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 5 ARG A 607
TYR A 629
TYR A 627
TRP A 703
 None
 1.35A 4f8yA-1rrhA:
0.0
4f8yB-1rrhA:
0.0		 4f8yA-1rrhA:
11.89
4f8yB-1rrhA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 5 TRP A 703
ARG A 607
TYR A 629
TYR A 627
 None
 1.24A 4f8yC-1rrhA:
undetectable
4f8yD-1rrhA:
undetectable		 4f8yC-1rrhA:
11.89
4f8yD-1rrhA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 ILE A 723
LEU A 767
ILE A 351
GLY A 314
 None
 0.84A 4hb8A-1rrhA:
undetectable		 4hb8A-1rrhA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.28A 4kcnB-1rrhA:
undetectable		 4kcnB-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 GLN A 514
HIS A 518
HIS A 709
HIS A 523
 None
FE2  A 858 ( 3.4A)
FE2  A 858 ( 3.4A)
FE2  A 858 ( 3.3A)
 0.75A 4n16A-1rrhA:
undetectable		 4n16A-1rrhA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 PHE A 301
TYR A 753
GLY A 721
ILE A 770
 None
 1.01A 4qoiA-1rrhA:
undetectable
4qoiB-1rrhA:
undetectable		 4qoiA-1rrhA:
15.38
4qoiB-1rrhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 6 GLU A 693
THR A 690
LEU A 658
TRP A 668
 None
 1.43A 4qztA-1rrhA:
undetectable		 4qztA-1rrhA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ILE A 572
SER A 582
TRP A 578
HIS A 513
HIS A 518
 None
None
None
None
FE2  A 858 ( 3.4A)
 1.49A 4rujA-1rrhA:
undetectable		 4rujA-1rrhA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 GLN A 514
HIS A 518
HIS A 709
HIS A 523
VAL A 769
 None
FE2  A 858 ( 3.4A)
FE2  A 858 ( 3.4A)
FE2  A 858 ( 3.3A)
None
 0.88A 4xiwB-1rrhA:
undetectable
4xiwE-1rrhA:
undetectable		 4xiwB-1rrhA:
13.33
4xiwE-1rrhA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 0.99A 5b3sC-1rrhA:
undetectable
5b3sJ-1rrhA:
undetectable		 5b3sC-1rrhA:
15.87
5b3sJ-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 0.99A 5b3sP-1rrhA:
undetectable		 5b3sP-1rrhA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 ASP A 203
ASN A 534
PHE A 529
 None
 0.54A 5dsgB-1rrhA:
undetectable		 5dsgB-1rrhA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 4 ILE A 117
ILE A 149
ARG A 159
LEU A 130
 None
 1.09A 5dzkh-1rrhA:
undetectable
5dzkn-1rrhA:
undetectable
5dzkv-1rrhA:
undetectable		 5dzkh-1rrhA:
12.66
5dzkn-1rrhA:
12.66
5dzkv-1rrhA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ILE A 723
GLY A 720
ASN A 725
PHE A 304
SER A 312
 None
 1.08A 5igyA-1rrhA:
1.2		 5igyA-1rrhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 ILE A 723
GLY A 720
ASN A 725
PHE A 304
SER A 312
 None
 1.05A 5ih0A-1rrhA:
undetectable		 5ih0A-1rrhA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		5 / 12 LEU A 469
LEU A 437
VAL A 505
SER A 730
LEU A 577
 None
 1.11A 5ikrB-1rrhA:
0.0		 5ikrB-1rrhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 7 ASP A 794
THR A 795
THR A 792
TYR A 651
 None
 1.07A 5ov9A-1rrhA:
undetectable		 5ov9A-1rrhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 ASP A 794
THR A 795
THR A 792
TYR A 651
 None
 1.12A 5ov9B-1rrhA:
undetectable		 5ov9B-1rrhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.30A 5vunA-1rrhA:
undetectable		 5vunA-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.31A 5vunB-1rrhA:
undetectable		 5vunB-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.28A 5vuoB-1rrhA:
undetectable		 5vuoB-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 5 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.08A 5x1bP-1rrhA:
1.9		 5x1bP-1rrhA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 SER A 517
ASN A 373
GLN A 716
ASN A 521
 None
 1.30A 6auuB-1rrhA:
0.0		 6auuB-1rrhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		3 / 3 GLY A 265
ASP A 779
ILE A  36
 None
 0.60A 6dgxB-1rrhA:
undetectable		 6dgxB-1rrhA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1rrh SEED LIPOXYGENASE-3
(Glycine
max) 		4 / 8 ASP A 509
GLY A 829
ASN A 725
VAL A 350
 None
 1.09A 6giqL-1rrhA:
undetectable
6giqP-1rrhA:
undetectable
6giqT-1rrhA:
undetectable		 6giqL-1rrhA:
21.50
6giqP-1rrhA:
13.82
6giqT-1rrhA:
6.33