SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 8 HIS A 277
HIS A 263
THR A 199
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 ( 3.3A)
None
ZN  A 387 ( 3.3A)
 1.06A 1azmA-1rrmA:
undetectable		 1azmA-1rrmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 8 HIS A 277
HIS A 263
THR A 199
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 ( 3.3A)
None
ZN  A 387 ( 3.3A)
 0.94A 1bzmA-1rrmA:
undetectable		 1bzmA-1rrmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 8 ARG A 120
ALA A 106
GLY A  80
ILE A  74
ILE A 154
 None
 1.25A 1hshD-1rrmA:
undetectable		 1hshD-1rrmA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 10 LEU A 378
VAL A 262
GLY A 264
ALA A 266
LEU A 269
 None
 1.12A 1pxxA-1rrmA:
undetectable		 1pxxA-1rrmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 103
ASP A 102
GLY A  96
GLY A  98
LEU A  42
 None
APR  A 389 ( 4.5A)
None
APR  A 389 (-3.2A)
APR  A 389 (-4.9A)
 1.05A 1rjdA-1rrmA:
2.5		 1rjdA-1rrmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 103
ASP A 102
GLY A  96
GLY A  98
LEU A  42
 None
APR  A 389 ( 4.5A)
None
APR  A 389 (-3.2A)
APR  A 389 (-4.9A)
 1.05A 1rjdB-1rrmA:
2.1		 1rjdB-1rrmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 103
ASP A 102
GLY A  96
GLY A  98
LEU A  42
 None
APR  A 389 ( 4.5A)
None
APR  A 389 (-3.2A)
APR  A 389 (-4.9A)
 1.06A 1rjdC-1rrmA:
2.4		 1rjdC-1rrmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 9 LEU A  81
ALA A 106
LEU A 122
GLU A 115
ALA A 117
 None
 1.20A 1sn0A-1rrmA:
0.0
1sn0C-1rrmA:
0.0		 1sn0A-1rrmA:
16.24
1sn0C-1rrmA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.31A 1v8bA-1rrmA:
2.6		 1v8bA-1rrmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.30A 1v8bB-1rrmA:
2.5		 1v8bB-1rrmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.31A 1v8bD-1rrmA:
3.3		 1v8bD-1rrmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 7 VAL A  19
GLY A  20
THR A  23
ASP A  53
 None
 0.91A 2a1mA-1rrmA:
undetectable		 2a1mA-1rrmA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  97
GLY A 194
ALA A 197
HIS A 200
ALA A 250
 APR  A 389 (-3.1A)
None
None
ZN  A 387 ( 3.3A)
None
 1.02A 2bm9F-1rrmA:
undetectable		 2bm9F-1rrmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 GLY A  98
GLY A 194
ALA A 197
HIS A 200
ALA A 250
 APR  A 389 (-3.2A)
None
None
ZN  A 387 ( 3.3A)
None
 0.84A 2bm9F-1rrmA:
undetectable		 2bm9F-1rrmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		6 / 12 GLY A  67
ASP A  39
ILE A  95
ILE A 107
ALA A  63
ILE A  64
 None
APR  A 389 (-2.7A)
None
None
None
None
 1.26A 2nmzA-1rrmA:
undetectable		 2nmzA-1rrmA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		6 / 12 GLY A  67
ASP A  39
ILE A  36
ILE A 107
ALA A  63
ILE A  64
 None
APR  A 389 (-2.7A)
None
None
None
None
 1.44A 2rkfB-1rrmA:
undetectable		 2rkfB-1rrmA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.71A 2y69A-1rrmA:
undetectable		 2y69A-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 2y69N-1rrmA:
2.1		 2y69N-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.73A 2zxwA-1rrmA:
undetectable		 2zxwA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 202
LEU A 285
LEU A 229
ILE A 225
ALA A 221
 None
 1.00A 3a50D-1rrmA:
undetectable		 3a50D-1rrmA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.73A 3abkA-1rrmA:
0.0		 3abkA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.70A 3abkN-1rrmA:
2.1		 3abkN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.77A 3ablA-1rrmA:
1.8		 3ablA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.78A 3ablN-1rrmA:
0.0		 3ablN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 3abmA-1rrmA:
0.0		 3abmA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3ag1A-1rrmA:
2.2		 3ag1A-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.76A 3ag1N-1rrmA:
0.1		 3ag1N-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 11 PHE A  14
GLY A  15
GLY A 240
GLN A 247
THR A 141
 None
None
None
None
APR  A 389 (-2.7A)
 1.16A 3ag1G-1rrmA:
0.0
3ag1N-1rrmA:
0.1
3ag1O-1rrmA:
0.0		 3ag1G-1rrmA:
10.57
3ag1N-1rrmA:
22.45
3ag1O-1rrmA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.70A 3ag2A-1rrmA:
0.8		 3ag2A-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3ag2N-1rrmA:
0.0		 3ag2N-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3ag3A-1rrmA:
2.2		 3ag3A-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3ag3N-1rrmA:
0.0		 3ag3N-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 3asnA-1rrmA:
0.0		 3asnA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3asnN-1rrmA:
0.0		 3asnN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 3asoA-1rrmA:
1.6		 3asoA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.76A 3asoN-1rrmA:
0.0		 3asoN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3bvdA-1rrmA:
1.7		 3bvdA-1rrmA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.36A 3ce6D-1rrmA:
2.7		 3ce6D-1rrmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 214
ASN A 256
ALA A 145
ALA A 201
ILE A 150
 None
 1.04A 3czhA-1rrmA:
undetectable		 3czhA-1rrmA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 214
ASN A 256
ALA A 145
ALA A 201
ILE A 150
 None
 0.99A 3czhB-1rrmA:
undetectable		 3czhB-1rrmA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 THR A 214
ASN A 256
ALA A 145
ALA A 201
ILE A 150
 None
 1.04A 3dl9B-1rrmA:
0.0		 3dl9B-1rrmA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3dtuA-1rrmA:
undetectable		 3dtuA-1rrmA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 3dtuC-1rrmA:
undetectable		 3dtuC-1rrmA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.37A 3g1uB-1rrmA:
3.6		 3g1uB-1rrmA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A  35
GLY A  88
ILE A 107
SER A 111
LEU A  81
 None
 1.13A 3gyqA-1rrmA:
undetectable
3gyqB-1rrmA:
undetectable		 3gyqA-1rrmA:
25.13
3gyqB-1rrmA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 10 VAL A  68
VAL A  37
LEU A  92
VAL A  77
GLY A  80
 None
 1.16A 3ls4H-1rrmA:
undetectable		 3ls4H-1rrmA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.36A 3n58C-1rrmA:
2.3		 3n58C-1rrmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 GLY A 270
ILE A 154
VAL A 153
 None
None
APR  A 389 (-4.6A)
 0.40A 3nv6A-1rrmA:
1.2		 3nv6A-1rrmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 259
ASP A 196
HIS A 277
HIS A 263
ALA A 250
 FE2  A 388 ( 4.1A)
ZN  A 387 (-2.6A)
ZN  A 387 (-3.3A)
ZN  A 387 ( 3.3A)
None
 1.22A 3r2jC-1rrmA:
undetectable		 3r2jC-1rrmA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 7 ILE A 109
ILE A 110
VAL A 119
LEU A 122
 None
 0.70A 3r9vA-1rrmA:
0.0
3r9vB-1rrmA:
0.0		 3r9vA-1rrmA:
20.65
3r9vB-1rrmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 3s3dA-1rrmA:
1.0		 3s3dA-1rrmA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 PHE A 254
TYR A 248
GLY A 251
GLY A 204
ALA A 201
 PGO  A 390 (-4.8A)
None
None
None
None
 1.10A 3sudB-1rrmA:
undetectable		 3sudB-1rrmA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 8 HIS A 277
HIS A 263
THR A 199
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 ( 3.3A)
None
ZN  A 387 ( 3.3A)
 0.99A 3w6hA-1rrmA:
undetectable		 3w6hA-1rrmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 3wg7N-1rrmA:
0.0		 3wg7N-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 378
VAL A 262
GLY A 264
ALA A 266
LEU A 269
 None
 1.10A 4coxC-1rrmA:
undetectable		 4coxC-1rrmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 6 ALA A 280
GLY A 264
LEU A 284
VAL A 262
 None
 0.94A 4dubA-1rrmA:
undetectable		 4dubA-1rrmA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 6 ALA A 280
GLY A 264
LEU A 284
VAL A 262
 None
 0.88A 4dubB-1rrmA:
undetectable		 4dubB-1rrmA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 ALA A 356
GLY A 270
ALA A 271
THR A 155
VAL A 153
 None
None
None
None
APR  A 389 (-4.6A)
 1.06A 4nkxC-1rrmA:
undetectable		 4nkxC-1rrmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 ALA A 356
GLY A 270
ALA A 271
THR A 155
VAL A 153
 None
None
None
None
APR  A 389 (-4.6A)
 1.03A 4nkxD-1rrmA:
undetectable		 4nkxD-1rrmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 6 LEU A 261
ASN A 292
LEU A 284
VAL A 327
 None
 1.16A 4okbA-1rrmA:
undetectable		 4okbA-1rrmA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 6 GLU A 147
THR A 149
GLN A 101
THR A 199
 None
PGO  A 390 ( 4.3A)
None
None
 1.03A 4pfjB-1rrmA:
3.7		 4pfjB-1rrmA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 5 ILE A 375
HIS A 277
TYR A 273
VAL A 345
 None
ZN  A 387 (-3.3A)
None
None
 1.14A 4s0vA-1rrmA:
2.5		 4s0vA-1rrmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.35A 5axdA-1rrmA:
2.8		 5axdA-1rrmA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.35A 5axdC-1rrmA:
4.0		 5axdC-1rrmA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 5b1aA-1rrmA:
0.0		 5b1aA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.72A 5b1bA-1rrmA:
undetectable		 5b1bA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.71A 5b3sA-1rrmA:
0.8		 5b3sA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.72A 5b3sN-1rrmA:
0.0		 5b3sN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.73A 5iy5A-1rrmA:
0.1		 5iy5A-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 5iy5N-1rrmA:
0.0		 5iy5N-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.33A 5m66A-1rrmA:
2.6		 5m66A-1rrmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.35A 5m66C-1rrmA:
4.2		 5m66C-1rrmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 200
ASP A 196
HIS A 277
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 (-3.3A)
 0.69A 5oexA-1rrmA:
undetectable		 5oexA-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 277
ASP A 196
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 ( 3.3A)
 0.45A 5oexA-1rrmA:
undetectable		 5oexA-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 200
ASP A 196
HIS A 277
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 (-3.3A)
 0.75A 5oexB-1rrmA:
undetectable		 5oexB-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 277
ASP A 196
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 ( 3.3A)
 0.35A 5oexB-1rrmA:
undetectable		 5oexB-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 200
ASP A 196
HIS A 277
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 (-3.3A)
 0.72A 5oexC-1rrmA:
undetectable		 5oexC-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 277
ASP A 196
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 ( 3.3A)
 0.33A 5oexC-1rrmA:
undetectable		 5oexC-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 200
ASP A 196
HIS A 277
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 (-3.3A)
 0.71A 5oexD-1rrmA:
undetectable		 5oexD-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 277
ASP A 196
HIS A 200
 ZN  A 387 (-3.3A)
ZN  A 387 (-2.6A)
ZN  A 387 ( 3.3A)
 0.36A 5oexD-1rrmA:
undetectable		 5oexD-1rrmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.35A 5utuF-1rrmA:
2.4		 5utuF-1rrmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 8 THR A 193
GLY A 194
ALA A 197
SER A 232
 APR  A 389 (-4.5A)
None
None
None
 0.69A 5vw9A-1rrmA:
2.6		 5vw9A-1rrmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.69A 5waua-1rrmA:
0.0		 5waua-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.71A 5x19A-1rrmA:
0.1		 5x19A-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.72A 5x19N-1rrmA:
undetectable		 5x19N-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.67A 5x1bA-1rrmA:
undetectable		 5x1bA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.65A 5x1bN-1rrmA:
undetectable		 5x1bN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 5x1fA-1rrmA:
0.0		 5x1fA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.73A 5xdqA-1rrmA:
undetectable		 5xdqA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.74A 5xdqN-1rrmA:
undetectable		 5xdqN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.71A 5xdxA-1rrmA:
undetectable		 5xdxA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.73A 5xdxN-1rrmA:
1.8		 5xdxN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.76A 5z86A-1rrmA:
undetectable		 5z86A-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		4 / 6 GLY A 344
ASP A 349
PRO A 276
GLY A 270
 None
 0.74A 6ag0C-1rrmA:
undetectable		 6ag0C-1rrmA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 ILE A 206
HIS A 263
CYH A 362
LEU A 259
GLY A 204
 None
ZN  A 387 ( 3.3A)
FE2  A 388 (-2.4A)
FE2  A 388 ( 4.1A)
None
 1.43A 6bp4B-1rrmA:
undetectable		 6bp4B-1rrmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A 263
ASP A 196
THR A 144
LEU A 259
GLY A 204
 ZN  A 387 ( 3.3A)
ZN  A 387 (-2.6A)
APR  A 389 (-4.0A)
FE2  A 388 ( 4.1A)
None
 1.40A 6f3nB-1rrmA:
4.3		 6f3nB-1rrmA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.71A 6hu9a-1rrmA:
undetectable		 6hu9a-1rrmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 6hu9m-1rrmA:
undetectable		 6hu9m-1rrmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.70A 6nknA-1rrmA:
0.0		 6nknA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.71A 6nknN-1rrmA:
0.0		 6nknN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.68A 6nmfA-1rrmA:
0.0		 6nmfA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.72A 6nmfN-1rrmA:
undetectable		 6nmfN-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.71A 6nmpA-1rrmA:
0.1		 6nmpA-1rrmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rrm LACTALDEHYDE
REDUCTASE
(Escherichia
coli) 		3 / 3 HIS A 263
HIS A 277
HIS A 267
 ZN  A 387 ( 3.3A)
ZN  A 387 (-3.3A)
None
 0.75A 6nmpN-1rrmA:
1.8		 6nmpN-1rrmA:
22.45