SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		5 / 10 PHE A  29
VAL A 106
GLY A  34
ILE A   2
PHE A  70
 None
 1.05A 1z11C-1rroA:
undetectable		 1z11C-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		5 / 10 PHE A  29
VAL A 106
GLY A  34
ILE A   2
PHE A  70
 None
 1.05A 1z11D-1rroA:
undetectable		 1z11D-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		4 / 7 PHE A 102
MET A 105
PHE A  30
ILE A  50
 None
 0.82A 2zseA-1rroA:
undetectable		 2zseA-1rroA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		4 / 4 ARG A  75
GLN A  71
PHE A  70
LEU A  77
 None
CA  A 135 (-3.3A)
None
None
 1.23A 3abkC-1rroA:
undetectable		 3abkC-1rroA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		4 / 5 ARG A  75
GLN A  71
LEU A  77
PHE A  24
 None
CA  A 135 (-3.3A)
None
None
 1.26A 3ablC-1rroA:
undetectable
3ablJ-1rroA:
undetectable		 3ablC-1rroA:
16.14
3ablJ-1rroA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		4 / 5 ARG A  75
GLN A  71
PHE A  70
LEU A  77
 None
CA  A 135 (-3.3A)
None
None
 1.39A 3ablC-1rroA:
undetectable
3ablJ-1rroA:
undetectable		 3ablC-1rroA:
16.14
3ablJ-1rroA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		5 / 12 PHE A  30
LEU A  15
PHE A  24
LEU A  85
LEU A  58
 None
 1.25A 3adsA-1rroA:
undetectable		 3adsA-1rroA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		5 / 10 PHE A  29
VAL A 106
PHE A  30
ILE A   2
PHE A  70
 None
 1.40A 3t3qA-1rroA:
undetectable		 3t3qA-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		5 / 10 PHE A  29
VAL A 106
PHE A  30
ILE A   2
PHE A  70
 None
 1.43A 3t3qB-1rroA:
undetectable		 3t3qB-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		5 / 10 PHE A  29
VAL A 106
PHE A  30
ILE A   2
PHE A  70
 None
 1.40A 3t3qC-1rroA:
undetectable		 3t3qC-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		5 / 10 PHE A  29
VAL A 106
PHE A  30
ILE A   2
PHE A  70
 None
 1.43A 3t3qD-1rroA:
undetectable		 3t3qD-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		4 / 7 PHE A  29
PHE A  70
ILE A  50
PHE A  66
 None
 0.87A 4ejjA-1rroA:
undetectable		 4ejjA-1rroA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1rro RAT ONCOMODULIN
(Rattus
rattus) 		4 / 7 ASP A  94
TYR A  57
ASP A 100
GLU A 104
 CA  A 109 (-2.9A)
None
None
None
 1.34A 6mn5E-1rroA:
undetectable		 6mn5E-1rroA:
20.54