SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 7 GLU A 383
LEU A 603
GLU A 387
LEU A 484
 None
 1.00A 1linA-1rt8A:
undetectable		 1linA-1rt8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.93A 1v55A-1rt8A:
0.0
1v55J-1rt8A:
undetectable		 1v55A-1rt8A:
22.05
1v55J-1rt8A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE A 122
SER A 134
LEU A 126
ASN A 123
 None
 1.11A 1y0xX-1rt8A:
undetectable		 1y0xX-1rt8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 549
GLY A 542
ASP A 595
ASN A 574
ALA A 575
 None
 0.99A 2bm9E-1rt8A:
undetectable		 2bm9E-1rt8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 224
ILE A 159
ILE A 203
ARG A 231
 None
 0.79A 2bu8A-1rt8A:
undetectable		 2bu8A-1rt8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.92A 2einA-1rt8A:
undetectable
2einJ-1rt8A:
undetectable		 2einA-1rt8A:
22.05
2einJ-1rt8A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 211
ALA A 210
GLY A 152
ALA A 197
ILE A 194
 None
 0.95A 2nmyB-1rt8A:
undetectable		 2nmyB-1rt8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 339
ALA A 354
TRP A 226
LEU A 353
 None
 1.05A 2oaxA-1rt8A:
undetectable		 2oaxA-1rt8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 11 THR A 498
VAL A 614
SER A 520
MET A 521
ILE A 552
 None
 1.18A 2zbzA-1rt8A:
0.0		 2zbzA-1rt8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLN A 419
ALA A 437
THR A 401
ASN A 452
GLY A 414
 SO4  A9004 ( 3.7A)
None
SO4  A9004 (-4.5A)
None
None
 1.44A 3aodC-1rt8A:
undetectable		 3aodC-1rt8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 158
ASP A 161
ASP A 165
GLY A 235
ILE A 228
 None
 1.09A 3ebzA-1rt8A:
undetectable		 3ebzA-1rt8A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 223
HIS A 121
TYR A 338
LEU A 351
LEU A 158
 None
 1.28A 3g9eA-1rt8A:
0.0		 3g9eA-1rt8A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU A 117
LEU A 351
LEU A 359
 None
 0.75A 3ohtA-1rt8A:
undetectable		 3ohtA-1rt8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU A 117
LEU A 351
LEU A 359
 None
 0.76A 3ohtB-1rt8A:
undetectable		 3ohtB-1rt8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 158
ASP A 161
ASP A 165
GLY A 235
ILE A 228
 None
 1.01A 3s53B-1rt8A:
undetectable		 3s53B-1rt8A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 293
ASN A 296
ARG A 282
GLY A 347
 None
 0.97A 4af0A-1rt8A:
undetectable		 4af0A-1rt8A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 223
HIS A 121
TYR A 338
LEU A 351
LEU A 158
 None
 1.24A 4emaA-1rt8A:
0.0		 4emaA-1rt8A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA501_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 181
LYS A 180
ASP A 182
LYS A 185
 None
 1.31A 4i90A-1rt8A:
0.0		 4i90A-1rt8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 492
TRP A 488
ILE A 495
 None
 1.05A 4mwxA-1rt8A:
undetectable		 4mwxA-1rt8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 609
LEU A 605
MET A 514
VAL A 515
ILE A 591
 None
 1.38A 4okbA-1rt8A:
0.0		 4okbA-1rt8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 8 LEU A 467
VAL A 457
ALA A 485
LEU A 482
ARG A 446
 None
 1.49A 4qrcA-1rt8A:
undetectable		 4qrcA-1rt8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 8 ILE A 229
LEU A 220
VAL A 193
LEU A 155
ILE A 213
 None
 1.36A 4r38D-1rt8A:
undetectable		 4r38D-1rt8A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 155
ILE A 159
GLY A 152
ILE A 167
 None
 0.87A 5dzk3-1rt8A:
undetectable
5dzkm-1rt8A:
undetectable		 5dzk3-1rt8A:
1.50
5dzkm-1rt8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE A 159
GLY A 152
ILE A 167
LEU A 155
 None
 0.78A 5dzki-1rt8A:
undetectable
5dzkj-1rt8A:
undetectable
5dzkx-1rt8A:
undetectable		 5dzki-1rt8A:
17.60
5dzkj-1rt8A:
17.60
5dzkx-1rt8A:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE A 159
GLY A 152
ILE A 167
LEU A 155
 None
 0.86A 5dzkd-1rt8A:
undetectable
5dzkk-1rt8A:
undetectable
5dzky-1rt8A:
undetectable		 5dzkd-1rt8A:
18.54
5dzkk-1rt8A:
17.60
5dzky-1rt8A:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 286
ASP A 293
GLY A 294
 None
 0.62A 5fctB-1rt8A:
undetectable		 5fctB-1rt8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 591
LEU A 611
ALA A 587
HIS A 606
 None
 1.00A 5hrqE-1rt8A:
undetectable
5hrqF-1rt8A:
undetectable
5hrqJ-1rt8A:
undetectable		 5hrqE-1rt8A:
4.53
5hrqF-1rt8A:
5.85
5hrqJ-1rt8A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 9 ILE A 475
VAL A 400
LEU A 395
ILE A 404
LEU A 467
 None
 1.12A 5iepA-1rt8A:
undetectable		 5iepA-1rt8A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY A 542
GLY A 565
LEU A 577
ARG A 576
ALA A 578
 None
 1.10A 5o96E-1rt8A:
undetectable
5o96F-1rt8A:
undetectable		 5o96E-1rt8A:
19.34
5o96F-1rt8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A 119
ILE A 122
LEU A 158
ILE A 110
ASN A 111
 None
 1.22A 5vkqA-1rt8A:
0.0
5vkqD-1rt8A:
0.0		 5vkqA-1rt8A:
15.13
5vkqD-1rt8A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A 110
ASN A 111
ILE A 119
ILE A 122
LEU A 158
 None
 1.22A 5vkqC-1rt8A:
0.0
5vkqD-1rt8A:
0.0		 5vkqC-1rt8A:
15.13
5vkqD-1rt8A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 5 ASN A 195
VAL A 390
LEU A 603
SER A 610
 None
 1.25A 6a7pA-1rt8A:
undetectable		 6a7pA-1rt8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 233
GLY A 232
VAL A 193
ARG A 231
ILE A 159
 None
 1.43A 6bxnB-1rt8A:
undetectable		 6bxnB-1rt8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 545
PHE A 607
ALA A 575
VAL A 557
TYR A 559
 None
 1.26A 6drxA-1rt8A:
undetectable		 6drxA-1rt8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 7 ARG A 260
HIS A 405
ASP A 256
GLU A 385
 None
SO4  A9002 (-4.3A)
None
None
 1.22A 6mn4F-1rt8A:
0.0		 6mn4F-1rt8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.85A 6nmpA-1rt8A:
0.0
6nmpJ-1rt8A:
undetectable		 6nmpA-1rt8A:
22.05
6nmpJ-1rt8A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rt8 FIMBRIN
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.88A 6nmpN-1rt8A:
0.0
6nmpW-1rt8A:
0.0		 6nmpN-1rt8A:
22.05
6nmpW-1rt8A:
9.50