SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rtg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		5 / 12 ALA A 570
ALA A 571
ASN A 573
LEU A 617
ALA A 619
 CL  A   1 ( 4.1A)
None
None
None
CL  A   1 (-3.4A)
 0.93A 2aclA-1rtgA:
undetectable
2aclE-1rtgA:
undetectable		 2aclA-1rtgA:
20.47
2aclE-1rtgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		4 / 8 ILE A 478
PHE A 632
ARG A 500
LEU A 623
 None
 0.91A 2eikN-1rtgA:
undetectable
2eikW-1rtgA:
undetectable		 2eikN-1rtgA:
17.56
2eikW-1rtgA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		4 / 8 ILE A 478
PHE A 632
ARG A 500
LEU A 623
 None
 0.91A 2eilN-1rtgA:
undetectable
2eilW-1rtgA:
undetectable		 2eilN-1rtgA:
17.56
2eilW-1rtgA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		4 / 8 ILE A 478
PHE A 632
ARG A 500
LEU A 623
 None
 0.91A 2einA-1rtgA:
undetectable
2einJ-1rtgA:
undetectable		 2einA-1rtgA:
17.56
2einJ-1rtgA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		5 / 12 THR A 580
PHE A 535
ALA A 479
ALA A 570
VAL A 568
 None
None
CA  A   2 ( 3.9A)
CL  A   1 ( 4.1A)
None
 1.13A 3czhB-1rtgA:
undetectable		 3czhB-1rtgA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		5 / 12 ILE A 613
ASN A 642
LEU A 617
ALA A 570
LEU A 645
 None
None
None
CL  A   1 ( 4.1A)
None
 1.14A 3dzyA-1rtgA:
undetectable		 3dzyA-1rtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		4 / 7 PHE A 583
ALA A 571
THR A 580
LEU A 561
 None
 1.10A 4ejgA-1rtgA:
undetectable		 4ejgA-1rtgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		4 / 8 LEU A 516
PHE A 488
ILE A 493
PHE A 534
 None
 0.76A 5eseA-1rtgA:
undetectable		 5eseA-1rtgA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1rtg HUMAN GELATINASE A
(Homo
sapiens) 		3 / 3 LYS A 576
ASN A 642
SER A 629
 None
 1.19A 5yw0A-1rtgA:
undetectable		 5yw0A-1rtgA:
20.95