SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 4 VAL A 310
TRP A 296
TRP A 309
 None
 1.39A 1gmkA-1rtkA:
undetectable
1gmkB-1rtkA:
undetectable		 1gmkA-1rtkA:
4.00
1gmkB-1rtkA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 GLY A 365
HIS A 367
THR A 363
ILE A 414
 None
 0.91A 1gtnF-1rtkA:
undetectable
1gtnG-1rtkA:
undetectable		 1gtnF-1rtkA:
10.28
1gtnG-1rtkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 GLY A 365
HIS A 367
THR A 363
ILE A 414
 None
 0.85A 1gtnJ-1rtkA:
undetectable
1gtnK-1rtkA:
undetectable		 1gtnJ-1rtkA:
10.28
1gtnK-1rtkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 8 GLY A 365
HIS A 367
THR A 363
ILE A 414
 None
 0.83A 1gtnP-1rtkA:
undetectable
1gtnQ-1rtkA:
undetectable		 1gtnP-1rtkA:
10.28
1gtnQ-1rtkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 GLN A 471
ILE A 474
ALA A 472
VAL A 496
VAL A 691
 None
 0.99A 1n4hA-1rtkA:
undetectable		 1n4hA-1rtkA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 GLN A 471
ILE A 474
ALA A 472
VAL A 691
ALA A 553
 None
 1.05A 1n4hA-1rtkA:
undetectable		 1n4hA-1rtkA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 5 SER A 253
SER A 255
THR A 328
ASN A 368
 MG  A 749 (-2.3A)
MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
None
 0.31A 1yvpA-1rtkA:
12.1		 1yvpA-1rtkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 6 SER A 253
SER A 255
THR A 328
ASN A 368
 MG  A 749 (-2.3A)
MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
None
 0.39A 1yvpB-1rtkA:
12.0		 1yvpB-1rtkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 SER A 253
SER A 255
THR A 328
ASN A 368
 MG  A 749 (-2.3A)
MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
None
 0.35A 2i91A-1rtkA:
6.4		 2i91A-1rtkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 7 SER A 253
SER A 255
THR A 328
ASN A 368
 MG  A 749 (-2.3A)
MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
None
 0.35A 2i91B-1rtkA:
11.3		 2i91B-1rtkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 MET A 244
TYR A 401
ASP A 399
ILE A 360
PHE A 403
 None
 1.47A 3a8iB-1rtkA:
0.3		 3a8iB-1rtkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 ASP A 602
ARG A 714
LYS A 623
 None
 1.11A 3wipG-1rtkA:
undetectable		 3wipG-1rtkA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		4 / 8 ILE A 272
LEU A 314
ILE A 360
GLY A 263
 None
 0.81A 4hb8A-1rtkA:
undetectable		 4hb8A-1rtkA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 PRO A 599
LEU A 598
HIS A 717
 None
 0.73A 4pevA-1rtkA:
5.5		 4pevA-1rtkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 VAL A 514
ILE A 474
GLY A 675
ASP A 551
ILE A 555
 None
 0.99A 4q5mA-1rtkA:
undetectable		 4q5mA-1rtkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 ASP A 364
ASP A 251
ASN A 329
 MG  A 749 ( 4.4A)
MG  A 749 ( 4.3A)
None
 0.66A 4q5mA-1rtkA:
undetectable		 4q5mA-1rtkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 10 VAL A 680
THR A 578
VAL A 689
LEU A 582
LEU A 598
 None
 1.25A 4yb6A-1rtkA:
undetectable
4yb6E-1rtkA:
undetectable		 4yb6A-1rtkA:
20.12
4yb6E-1rtkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 10 VAL A 680
THR A 578
VAL A 689
LEU A 582
LEU A 598
 None
 1.25A 4yb6B-1rtkA:
undetectable
4yb6C-1rtkA:
undetectable		 4yb6B-1rtkA:
20.12
4yb6C-1rtkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 10 LEU A 582
LEU A 598
VAL A 680
THR A 578
VAL A 689
 None
 1.23A 4yb6B-1rtkA:
undetectable
4yb6F-1rtkA:
undetectable		 4yb6B-1rtkA:
20.12
4yb6F-1rtkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 TYR A 465
THR A 566
THR A 463
 None
IOD  A 741 ( 4.5A)
None
 0.79A 5aoxB-1rtkA:
0.0		 5aoxB-1rtkA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		3 / 3 TYR A 465
THR A 566
THR A 463
 None
IOD  A 741 ( 4.5A)
None
 0.76A 5aoxE-1rtkA:
0.0		 5aoxE-1rtkA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 11 PRO A 373
LEU A 334
VAL A 287
TYR A 289
LEU A 361
 None
 1.31A 5hbmA-1rtkA:
0.6		 5hbmA-1rtkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 VAL A 491
LEU A 656
VAL A 691
GLY A 690
LEU A 572
 None
 0.90A 5iktA-1rtkA:
undetectable		 5iktA-1rtkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 9 SER A 255
THR A 328
SER A 253
ILE A 256
THR A 330
 MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
MG  A 749 (-2.3A)
None
None
 1.47A 5muoA-1rtkA:
0.0
5muoB-1rtkA:
0.0
5muoC-1rtkA:
0.0
5muoD-1rtkA:
0.0
5muoE-1rtkA:
0.0		 5muoA-1rtkA:
10.86
5muoB-1rtkA:
10.86
5muoC-1rtkA:
10.86
5muoD-1rtkA:
10.86
5muoE-1rtkA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 HIS A 501
ASP A 551
GLY A 672
SER A 674
VAL A 696
 GBS  A 750 (-4.1A)
None
None
GBS  A 750 (-1.3A)
None
 0.87A 6c2mC-1rtkA:
2.6		 6c2mC-1rtkA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1rtk COMPLEMENT FACTOR B
(Homo
sapiens) 		5 / 12 LEU A 271
ILE A 360
LEU A 334
LEU A 286
GLY A 285
 None
 1.40A 6qyaB-1rtkA:
undetectable		 6qyaB-1rtkA:
20.16