SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rtw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		5 / 10 LEU A  40
LEU A  94
ILE A  98
PHE A  22
ILE A 204
 None
 1.42A 1i18A-1rtwA:
undetectable
1i18B-1rtwA:
undetectable		 1i18A-1rtwA:
20.36
1i18B-1rtwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 LEU A 175
LEU A 172
ILE A 171
ILE A 168
LEU A 119
 None
 0.81A 1xdkF-1rtwA:
undetectable		 1xdkF-1rtwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		4 / 5 ALA A 135
TRP A 202
LEU A 199
ALA A 131
 None
 1.10A 2jstA-1rtwA:
0.0
2jstB-1rtwA:
0.0		 2jstA-1rtwA:
19.10
2jstB-1rtwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		4 / 7 TYR A 206
GLU A  25
TRP A 202
TRP A 138
 None
 1.48A 3cotA-1rtwA:
0.0		 3cotA-1rtwA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		5 / 12 LEU A 125
LEU A  57
ALA A  61
PHE A 118
ASP A  64
 None
 1.31A 3gwuA-1rtwA:
undetectable		 3gwuA-1rtwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 ARG A 101
ASP A  99
TRP A 100
 None
 0.98A 4xdqA-1rtwA:
undetectable		 4xdqA-1rtwA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		4 / 6 ALA A  50
LEU A  51
ILE A  73
TYR A 164
 MP5  A1213 (-3.6A)
None
None
None
 0.86A 5mvmB-1rtwA:
4.0
5mvmC-1rtwA:
4.0		 5mvmB-1rtwA:
17.54
5mvmC-1rtwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		5 / 10 ILE A 204
VAL A 106
LEU A 109
PHE A 201
GLU A 128
 None
None
None
MP5  A1213 (-3.3A)
MP5  A1213 (-3.8A)
 1.46A 5tixB-1rtwA:
undetectable		 5tixB-1rtwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 HIS A  20
GLU A  25
ASN A  35
 None
 1.02A 5wbvA-1rtwA:
0.0		 5wbvA-1rtwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 HIS A  20
GLU A  25
ASN A  35
 None
 1.02A 5wbvB-1rtwA:
0.0		 5wbvB-1rtwA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		3 / 3 TYR A  44
ALA A  50
LEU A  51
 None
MP5  A1213 (-3.6A)
None
 0.67A 6ag0C-1rtwA:
undetectable		 6ag0C-1rtwA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 1rtw TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE
(Pyrococcus
furiosus) 		4 / 6 GLU A 198
LYS A 130
GLU A 134
ALA A 135
 MP5  A1213 (-2.6A)
None
None
None
 1.24A 6an0A-1rtwA:
0.5		 6an0A-1rtwA:
19.60