SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ru1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_2 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	1ru1	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Escherichia coli)	3 / 3	LEU A 15 VAL A 18 LEU A 22	None	0.53A	1mz9B-1ru1A: undetectable	1mz9B-1ru1A: 14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DAJ_B_0HKB2000_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3, LYSOZYME)	1ru1	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Escherichia coli)	3 / 3	ASN A 103 LEU A 128 PHE A 101	None	0.78A	4dajB-1ru1A: undetectable	4dajB-1ru1A: 16.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M5M_A_DX4A401_0 (2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE)	1ru1	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Escherichia coli)	5 / 8	GLY A 8 THR A 42 TYR A 53 ASN A 55 PHE A 123	PH2 A 181 ( 3.9A) PH2 A 181 (-3.4A) PH2 A 181 (-3.6A) PH2 A 181 (-2.9A) PH2 A 181 (-3.5A)	0.43A	4m5mA-1ru1A: 25.5	4m5mA-1ru1A: 95.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KMF_A_6U9A1301_1 (ION TRANSPORT PROTEIN)	1ru1	2-AMINO-4-HYDROXY-6- HYDROXYMETHYLDIHYDRO PTERIDINE PYROPHOSPHOKINASE (Escherichia coli)	4 / 6	GLY A 102 PHE A 101 TYR A 4 ILE A 5	None	0.90A	5kmfA-1ru1A: undetectable 5kmfC-1ru1A: undetectable	5kmfA-1ru1A: 19.23 5kmfC-1ru1A: 19.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MZ9_D_VDYD1001_2","CARTILAGE OLIGOMERIC MATRIX PROTEIN;CARTILAGE OLIGOMERIC MATRIX PROTEIN","1ru1","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Escherichia coli",3,"LEU A  15;VAL A  18;LEU A  22","None","0.53A","1mz9B-1ru1A:undetectable","1mz9B-1ru1A:14.67"],["4DAJ_B_0HKB2000_2","MUSCARINIC ACETYLCHOLINE RECEPTOR M3, LYSOZYME","1ru1","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Escherichia coli",3,"ASN A 103;LEU A 128;PHE A 101","None","0.78A","4dajB-1ru1A:undetectable","4dajB-1ru1A:16.53"],["4M5M_A_DX4A401_0","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","1ru1","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Escherichia coli",5,"GLY A   8;THR A  42;TYR A  53;ASN A  55;PHE A 123","PH2 A 181 ( 3.9A);PH2 A 181 (-3.4A);PH2 A 181 (-3.6A);PH2 A 181 (-2.9A);PH2 A 181 (-3.5A)","0.43A","4m5mA-1ru1A:25.5","4m5mA-1ru1A:95.57"],["5KMF_A_6U9A1301_1","ION TRANSPORT PROTEIN;ION TRANSPORT PROTEIN","1ru1","2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE","Escherichia coli",4,"GLY A 102;PHE A 101;TYR A   4;ILE A   5","None","0.90A","5kmfA-1ru1A:undetectable;5kmfC-1ru1A:undetectable","5kmfA-1ru1A:19.23;5kmfC-1ru1A:19.23"]]