SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ru4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 8 PHE A 171
VAL A 190
VAL A 137
VAL A 159
 None
 0.90A 1iwiA-1ru4A:
undetectable		 1iwiA-1ru4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 4 VAL A  70
ALA A  66
LEU A  78
PHE A  63
 None
 1.20A 1q97B-1ru4A:
undetectable		 1q97B-1ru4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 HIS A 283
ASP A 299
ASN A 268
 None
 0.88A 1wg8B-1ru4A:
undetectable		 1wg8B-1ru4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 12 ILE A  95
MET A  67
LEU A  78
PHE A 135
PHE A 144
 None
 1.31A 1y0xX-1ru4A:
undetectable		 1y0xX-1ru4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 12 ILE A  76
LEU A  77
ALA A  66
GLY A  54
SER A  55
 None
 0.88A 2a58A-1ru4A:
undetectable
2a58B-1ru4A:
undetectable		 2a58A-1ru4A:
18.75
2a58B-1ru4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 12 ILE A  76
LEU A  77
ALA A  66
GLY A  54
SER A  55
 None
 0.88A 2a58B-1ru4A:
undetectable
2a58C-1ru4A:
undetectable		 2a58B-1ru4A:
18.75
2a58C-1ru4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 12 ILE A  76
LEU A  77
ALA A  66
GLY A  54
SER A  55
 None
 0.89A 2a58D-1ru4A:
undetectable
2a58E-1ru4A:
undetectable		 2a58D-1ru4A:
18.75
2a58E-1ru4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 8 ARG A 284
ILE A 285
ASP A 234
GLY A 271
PHE A 298
 None
None
CA  A   1 (-3.4A)
None
None
 1.40A 2tsrB-1ru4A:
undetectable		 2tsrB-1ru4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 7 GLY A 178
ASP A 194
TRP A 229
ARG A 227
 None
 0.78A 3arrA-1ru4A:
undetectable		 3arrA-1ru4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 7 GLY A 178
ASP A 194
TRP A 229
ARG A 227
 None
 0.81A 3aruA-1ru4A:
undetectable		 3aruA-1ru4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 SER A  34
GLY A 115
GLY A 146
 None
 0.46A 3bogA-1ru4A:
undetectable
3bogC-1ru4A:
undetectable		 3bogA-1ru4A:
undetectable
3bogC-1ru4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 GLY A 218
GLY A 161
GLY A 184
 None
 0.40A 3bogC-1ru4A:
undetectable		 3bogC-1ru4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 GLY A 297
GLY A 269
GLY A 271
 None
 0.27A 3bogC-1ru4A:
undetectable		 3bogC-1ru4A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 4 GLU A 167
GLY A 146
THR A 169
GLU A 148
 None
 1.16A 3e9xA-1ru4A:
undetectable		 3e9xA-1ru4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 12 GLY A 134
ALA A 157
PHE A 119
ASN A 174
HIS A 173
 None
 1.49A 3s8pA-1ru4A:
undetectable		 3s8pA-1ru4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 7 ASN A 293
ALA A 290
ARG A 227
ALA A 228
 None
 1.07A 3twpB-1ru4A:
undetectable		 3twpB-1ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 7 ASN A 293
ALA A 290
ARG A 227
ALA A 228
 None
 0.98A 3twpC-1ru4A:
undetectable		 3twpC-1ru4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 12 VAL A 118
ALA A 117
GLY A 146
ASP A 120
THR A 150
 None
 1.38A 4mm4A-1ru4A:
undetectable		 4mm4A-1ru4A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 VAL A 289
ALA A 252
PHE A 298
 None
 0.93A 4olbA-1ru4A:
undetectable		 4olbA-1ru4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 4 GLY A 281
VAL A 307
PHE A 236
ILE A 247
 None
 1.10A 4xv2B-1ru4A:
undetectable		 4xv2B-1ru4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 VAL A 289
ALA A 252
PHE A 298
 None
 0.90A 4z4iA-1ru4A:
0.0		 4z4iA-1ru4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 8 ASP A 234
ASP A 209
ASP A 237
GLU A 180
 CA  A   1 (-3.4A)
CA  A   1 (-2.2A)
CA  A   1 (-3.4A)
None
 1.03A 5cfsA-1ru4A:
undetectable		 5cfsA-1ru4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 VAL A 289
ALA A 252
PHE A 298
 None
 0.91A 5js1A-1ru4A:
0.0		 5js1A-1ru4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 6 MET A 207
ASP A 209
LYS A 214
ASP A 234
 None
CA  A   1 (-2.2A)
CA  A   1 ( 4.3A)
CA  A   1 (-3.4A)
 1.17A 5logA-1ru4A:
undetectable		 5logA-1ru4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		3 / 3 ARG A 284
PHE A 211
LEU A 274
 None
 0.67A 5veuA-1ru4A:
undetectable		 5veuA-1ru4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 6 TRP A 229
HIS A 172
ARG A 116
GLU A 148
 None
 1.29A 5x7pA-1ru4A:
undetectable		 5x7pA-1ru4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 6 TRP A 229
HIS A 172
ARG A 116
GLU A 148
 None
 1.27A 5x7pB-1ru4A:
undetectable		 5x7pB-1ru4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 6 TRP A 229
HIS A 172
ARG A 116
GLU A 148
 None
 1.30A 5x7qA-1ru4A:
undetectable		 5x7qA-1ru4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 6 TRP A 229
HIS A 172
ARG A 116
GLU A 148
 None
 1.30A 5x7qB-1ru4A:
0.0		 5x7qB-1ru4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 6 TRP A 229
HIS A 172
ARG A 116
GLU A 148
 None
 1.31A 5x7rA-1ru4A:
undetectable		 5x7rA-1ru4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 6 TRP A 229
HIS A 172
ARG A 116
GLU A 148
 None
 1.29A 5x7rB-1ru4A:
undetectable		 5x7rB-1ru4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 12 LEU A 274
LEU A 238
GLY A 271
GLY A 269
ASN A 302
 None
 1.13A 6ce2B-1ru4A:
undetectable		 6ce2B-1ru4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		5 / 9 LEU A 394
SER A 395
PHE A 368
LEU A 371
VAL A 339
 None
 1.14A 6ftpA-1ru4A:
0.0
6ftpB-1ru4A:
undetectable		 6ftpA-1ru4A:
10.78
6ftpB-1ru4A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1ru4 PECTATE LYASE
(Dickeya
chrysanthemi) 		4 / 7 HIS A 172
THR A 150
ARG A 380
ASP A 194
 None
 1.35A 6mn4E-1ru4A:
undetectable		 6mn4E-1ru4A:
19.76