SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		4 / 7 VAL A  18
GLY A  16
THR A  69
ILE A  75
 None
 0.81A 1gtnC-1rvvA:
undetectable
1gtnD-1rvvA:
undetectable		 1gtnC-1rvvA:
23.66
1gtnD-1rvvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 9 ALA A  34
ILE A  15
VAL A  43
ILE A 112
ILE A  76
 None
 0.84A 1hshB-1rvvA:
undetectable		 1hshB-1rvvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		6 / 12 GLY A  33
ALA A  34
ILE A 112
GLY A 114
VAL A  50
ILE A  17
 None
 1.48A 1muiB-1rvvA:
undetectable		 1muiB-1rvvA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 10 GLY A  20
VAL A  53
GLY A  55
THR A  27
VAL A  18
 None
None
INI  A 200 (-3.4A)
None
None
 1.28A 1v3qE-1rvvA:
3.0		 1v3qE-1rvvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		6 / 11 GLY A  33
ALA A  34
ILE A 112
GLY A 114
VAL A  50
ILE A  17
 None
 1.44A 2aquB-1rvvA:
undetectable		 2aquB-1rvvA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		6 / 12 GLY A  33
ALA A  34
ILE A 112
GLY A 114
VAL A  50
ILE A  17
 None
 1.44A 2avoB-1rvvA:
undetectable		 2avoB-1rvvA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 12 SER A  32
LEU A  78
ASN A 134
VAL A  50
ILE A  26
 None
 1.06A 2nnhA-1rvvA:
0.0		 2nnhA-1rvvA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 8 ALA A 124
GLY A  79
LEU A  30
GLY A 136
ASP A 138
 None
 1.45A 2yfxA-1rvvA:
undetectable		 2yfxA-1rvvA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		4 / 8 GLY A  99
GLU A  95
ILE A  59
ALA A  63
 None
 0.90A 3aodA-1rvvA:
undetectable		 3aodA-1rvvA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		6 / 12 GLY A  33
ALA A  34
ILE A 112
GLY A 114
VAL A  50
ILE A  17
 None
 1.31A 3el1B-1rvvA:
undetectable		 3el1B-1rvvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		6 / 11 GLY A  33
ALA A  34
ILE A 112
GLY A 114
VAL A  50
ILE A  17
 None
 1.45A 3em4U-1rvvA:
undetectable		 3em4U-1rvvA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		6 / 11 GLY A  33
ALA A  34
ILE A 112
GLY A 114
VAL A  50
ILE A  17
 None
 1.40A 3ndxB-1rvvA:
undetectable		 3ndxB-1rvvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 11 GLY A  55
ILE A  59
GLU A  58
PHE A  57
ALA A  96
 INI  A 200 (-3.4A)
None
INI  A 200 (-2.7A)
INI  A 200 (-4.9A)
None
 1.12A 3nmuB-1rvvA:
undetectable
3nmuJ-1rvvA:
undetectable		 3nmuB-1rvvA:
17.38
3nmuJ-1rvvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 9 ALA A  34
ILE A  15
VAL A  43
ILE A 112
ILE A  76
 None
 0.89A 3s43A-1rvvA:
undetectable		 3s43A-1rvvA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 11 ASP A  44
VAL A  43
ILE A  48
GLY A  16
ILE A  75
 None
 1.00A 4njtA-1rvvA:
undetectable		 4njtA-1rvvA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		3 / 3 LEU A   8
VAL A 137
ASP A 138
 None
 0.48A 4y8wC-1rvvA:
undetectable		 4y8wC-1rvvA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1rvv RIBOFLAVIN SYNTHASE
(Bacillus
subtilis) 		5 / 12 GLY A  79
VAL A  81
GLY A 114
ILE A  75
ALA A 103
 None
INI  A 200 (-3.2A)
None
None
None
 1.02A 5x7fA-1rvvA:
undetectable		 5x7fA-1rvvA:
19.20