SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		5 / 12 PHE A  84
PHE A 146
VAL A 108
PHE A 116
VAL A 120
 None
 1.21A 1q23B-1rw2A:
undetectable		 1q23B-1rw2A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		5 / 11 PHE A  84
PHE A 146
VAL A 108
PHE A 116
VAL A 120
 None
 1.23A 1q23J-1rw2A:
undetectable		 1q23J-1rw2A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A  81
ARG A  96
PHE A  97
ILE A 128
 None
 1.03A 2q6hA-1rw2A:
undetectable		 2q6hA-1rw2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A  81
ARG A  96
PHE A  97
ILE A 128
 None
 1.03A 2qb4A-1rw2A:
undetectable		 2qb4A-1rw2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		3 / 3 GLU A  63
LEU A  66
ASP A  67
 None
 0.28A 3ko0A-1rw2A:
undetectable		 3ko0A-1rw2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		3 / 3 GLU A  63
LEU A  66
ASP A  67
 None
 0.25A 3ko0T-1rw2A:
undetectable		 3ko0T-1rw2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		3 / 3 GLU A  87
ALA A  88
PHE A  91
 None
 0.31A 4v1fA-1rw2A:
undetectable		 4v1fA-1rw2A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		3 / 3 GLU A  87
ALA A  88
PHE A  91
 None
 0.37A 4v1fC-1rw2A:
undetectable		 4v1fC-1rw2A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens) 		3 / 3 LYS A  76
GLN A  57
ASN A  39
 None
 0.83A 5l2tA-1rw2A:
undetectable		 5l2tA-1rw2A:
19.05