SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 ARG A 134
GLU A 412
ARG A 296
ASN A 410
TYR A 242
 None
None
PO4  A 850 ( 4.2A)
None
PO4  A 850 (-4.8A)
 1.49A 1a4gB-1rw9A:
undetectable		 1a4gB-1rw9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 10 THR A 478
ALA A 485
PHE A 505
ALA A 699
LEU A 712
 None
 1.33A 1claA-1rw9A:
undetectable		 1claA-1rw9A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 542
THR A 544
LEU A 581
LEU A 559
GLY A 560
 None
 1.47A 1d4fA-1rw9A:
undetectable		 1d4fA-1rw9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 7 ARG A 134
ASN A 124
ARG A 296
ARG A 300
ASN A 410
 None
None
PO4  A 850 ( 4.2A)
None
None
 1.26A 1f9gA-1rw9A:
45.5		 1f9gA-1rw9A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 ARG A 134
TYR A 238
ARG A 296
ARG A 300
 None
None
PO4  A 850 ( 4.2A)
None
 1.15A 1f9gA-1rw9A:
45.5		 1f9gA-1rw9A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		6 / 7 ASN A 124
TRP A 126
TYR A 242
ARG A 296
ARG A 300
ASN A 410
 None
PO4  A 850 (-4.7A)
PO4  A 850 (-4.8A)
PO4  A 850 ( 4.2A)
None
None
 0.55A 1f9gA-1rw9A:
45.5		 1f9gA-1rw9A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 GLU A 586
ILE A 529
ILE A 450
ARG A 588
GLU A 527
 None
 1.02A 1ki7B-1rw9A:
undetectable		 1ki7B-1rw9A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 4 LEU A 246
VAL A 185
CYH A 188
ALA A 207
 None
 1.17A 1mz9E-1rw9A:
0.0		 1mz9E-1rw9A:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		3 / 3 GLU A 407
TRP A 465
LYS A 749
 None
 0.82A 1qu2A-1rw9A:
3.1		 1qu2A-1rw9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 10 ARG A 446
GLY A 616
THR A 451
VAL A 526
GLU A 527
 None
 1.43A 1z35A-1rw9A:
undetectable		 1z35A-1rw9A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 THR A 602
GLY A 590
THR A 441
ALA A 440
 None
 0.88A 2a1hA-1rw9A:
undetectable
2a1hB-1rw9A:
undetectable		 2a1hA-1rw9A:
19.15
2a1hB-1rw9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 6 GLU A 151
TYR A 155
ASP A 109
ARG A  57
 None
 0.93A 2a3bB-1rw9A:
undetectable		 2a3bB-1rw9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_B_H4BB1001_1
(HYPOTHETICAL PROTEIN
PH0634)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 10 ILE A 285
TYR A 425
ASP A 291
HIS A 536
THR A 428
 None
 1.39A 2dttA-1rw9A:
0.0
2dttB-1rw9A:
1.4		 2dttA-1rw9A:
9.38
2dttB-1rw9A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		6 / 12 HIS A 536
ALA A 553
THR A 552
ALA A 550
ARG A 533
ALA A 609
 None
 1.46A 2gluB-1rw9A:
undetectable		 2gluB-1rw9A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 THR A 704
PRO A 703
GLU A 473
PRO A 684
 None
 0.92A 2v2gA-1rw9A:
undetectable
2v2gB-1rw9A:
undetectable		 2v2gA-1rw9A:
14.97
2v2gB-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 PRO A 684
THR A 704
PRO A 703
GLU A 473
 None
 0.95A 2v2gA-1rw9A:
undetectable
2v2gB-1rw9A:
undetectable		 2v2gA-1rw9A:
14.97
2v2gB-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 THR A 704
PRO A 703
GLU A 473
PRO A 684
 None
 0.93A 2v2gC-1rw9A:
undetectable
2v2gD-1rw9A:
undetectable		 2v2gC-1rw9A:
14.97
2v2gD-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 PRO A 684
THR A 704
PRO A 703
GLU A 473
 None
 0.94A 2v2gC-1rw9A:
undetectable
2v2gD-1rw9A:
undetectable		 2v2gC-1rw9A:
14.97
2v2gD-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 THR A 704
PRO A 703
GLU A 473
PRO A 684
 None
 0.96A 2v32A-1rw9A:
undetectable
2v32B-1rw9A:
undetectable		 2v32A-1rw9A:
14.97
2v32B-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 PRO A 684
THR A 704
PRO A 703
GLU A 473
 None
 0.92A 2v32A-1rw9A:
undetectable
2v32B-1rw9A:
undetectable		 2v32A-1rw9A:
14.97
2v32B-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 THR A 704
PRO A 703
GLU A 473
PRO A 684
 None
 0.88A 2v32C-1rw9A:
undetectable
2v32D-1rw9A:
undetectable		 2v32C-1rw9A:
14.97
2v32D-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 PRO A 684
THR A 704
PRO A 703
GLU A 473
 None
 0.94A 2v32C-1rw9A:
undetectable
2v32D-1rw9A:
undetectable		 2v32C-1rw9A:
14.97
2v32D-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 THR A 704
PRO A 703
GLU A 473
PRO A 684
 None
 0.98A 2v41C-1rw9A:
undetectable
2v41D-1rw9A:
undetectable		 2v41C-1rw9A:
14.97
2v41D-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 PRO A 684
THR A 704
PRO A 703
GLU A 473
 None
 0.90A 2v41C-1rw9A:
undetectable
2v41D-1rw9A:
undetectable		 2v41C-1rw9A:
14.97
2v41D-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 PRO A 684
THR A 704
PRO A 703
GLU A 473
 None
 0.99A 2v41E-1rw9A:
undetectable
2v41F-1rw9A:
undetectable		 2v41E-1rw9A:
14.97
2v41F-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 THR A 704
PRO A 703
GLU A 473
PRO A 684
 None
 0.90A 2v41G-1rw9A:
undetectable
2v41H-1rw9A:
undetectable		 2v41G-1rw9A:
14.97
2v41H-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 PRO A 684
THR A 704
PRO A 703
GLU A 473
 None
 0.98A 2v41G-1rw9A:
undetectable
2v41H-1rw9A:
undetectable		 2v41G-1rw9A:
14.97
2v41H-1rw9A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 LEU A 362
ARG A 332
GLY A 333
ALA A 336
 None
 0.77A 2xfsA-1rw9A:
0.0		 2xfsA-1rw9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 LEU A 362
ARG A 332
GLY A 333
ALA A 336
 None
 0.77A 2xh9A-1rw9A:
0.0		 2xh9A-1rw9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 TYR A 417
VAL A 595
TYR A 406
ILE A 298
 None
 1.33A 2xz5B-1rw9A:
undetectable
2xz5E-1rw9A:
undetectable		 2xz5B-1rw9A:
13.61
2xz5E-1rw9A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 ILE A 298
TYR A 417
VAL A 595
TYR A 406
 None
 1.34A 2xz5D-1rw9A:
undetectable
2xz5E-1rw9A:
undetectable		 2xz5D-1rw9A:
13.61
2xz5E-1rw9A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		3 / 3 MET A 386
GLU A 372
ASP A 342
 None
 0.88A 3a25A-1rw9A:
undetectable		 3a25A-1rw9A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 11 LEU A 143
LEU A 136
ALA A 139
LEU A  79
ALA A 110
 None
 0.99A 3e22B-1rw9A:
undetectable		 3e22B-1rw9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 11 LEU A 143
LEU A 136
ALA A 139
LEU A  79
ALA A 110
 None
 0.98A 3e22D-1rw9A:
undetectable		 3e22D-1rw9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 GLY A 375
MET A 627
CYH A 513
PHE A 660
 None
 1.08A 3ko0D-1rw9A:
undetectable
3ko0E-1rw9A:
undetectable		 3ko0D-1rw9A:
8.45
3ko0E-1rw9A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 GLY A 389
MET A 627
CYH A 513
PHE A 660
 None
 0.88A 3ko0D-1rw9A:
undetectable
3ko0E-1rw9A:
undetectable		 3ko0D-1rw9A:
8.45
3ko0E-1rw9A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 PHE A 660
GLY A 389
MET A 627
CYH A 513
 None
 0.96A 3ko0B-1rw9A:
undetectable
3ko0J-1rw9A:
undetectable		 3ko0B-1rw9A:
8.45
3ko0J-1rw9A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 GLY A 389
MET A 627
CYH A 513
PHE A 660
 None
 0.97A 3ko0L-1rw9A:
undetectable
3ko0N-1rw9A:
0.1		 3ko0L-1rw9A:
8.45
3ko0N-1rw9A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 GLY A 389
MET A 627
CYH A 513
PHE A 660
 None
 0.98A 3ko0M-1rw9A:
0.6
3ko0P-1rw9A:
undetectable		 3ko0M-1rw9A:
8.45
3ko0P-1rw9A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 PHE A 660
GLY A 389
MET A 627
CYH A 513
 None
 0.94A 3ko0K-1rw9A:
0.7
3ko0S-1rw9A:
0.0		 3ko0K-1rw9A:
8.45
3ko0S-1rw9A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 PHE A 660
GLY A 389
MET A 627
CYH A 513
 None
 0.95A 3ko0R-1rw9A:
0.1
3ko0T-1rw9A:
undetectable		 3ko0R-1rw9A:
8.45
3ko0T-1rw9A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		3 / 3 VAL A 486
VAL A 506
TRP A 504
 None
 0.88A 3l8lA-1rw9A:
undetectable
3l8lB-1rw9A:
undetectable		 3l8lA-1rw9A:
4.56
3l8lB-1rw9A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 515
GLN A 656
VAL A 486
LEU A 396
ILE A 529
 None
 1.35A 3mnoA-1rw9A:
undetectable		 3mnoA-1rw9A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 515
GLN A 656
VAL A 486
LEU A 396
ILE A 529
 None
 1.36A 3mnpA-1rw9A:
undetectable		 3mnpA-1rw9A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 261
PHE A   9
LEU A  12
ARG A  13
LEU A 256
 None
 1.22A 3nrrA-1rw9A:
undetectable		 3nrrA-1rw9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 ALA A 292
TRP A 439
MET A 423
ALA A 397
 None
 1.20A 3tx2A-1rw9A:
undetectable		 3tx2A-1rw9A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 ARG A 501
THR A 499
PHE A 505
ALA A 667
ALA A 685
 None
 1.37A 3ua1A-1rw9A:
undetectable		 3ua1A-1rw9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 6 HIS A 536
ASP A 430
ASN A 286
GLU A 372
 None
 1.28A 3vywA-1rw9A:
undetectable		 3vywA-1rw9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 SER A 399
ASP A 383
THR A 419
SER A 400
 None
 0.97A 4ac9C-1rw9A:
undetectable		 4ac9C-1rw9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 ILE A 130
GLY A 131
VAL A 185
SER A 251
 None
 0.89A 4acbB-1rw9A:
undetectable
4acbC-1rw9A:
undetectable		 4acbB-1rw9A:
21.95
4acbC-1rw9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 ASP A 383
GLU A 702
ASP A 472
GLU A 473
 None
 1.20A 4fewD-1rw9A:
undetectable		 4fewD-1rw9A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 LEU A 698
ARG A 757
ARG A 691
SER A 657
 None
 1.26A 4klrA-1rw9A:
0.0		 4klrA-1rw9A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 5 THR A 520
LEU A 498
THR A 419
MET A 423
 None
 1.42A 4mbsB-1rw9A:
undetectable		 4mbsB-1rw9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 9 PRO A 715
ILE A 753
ALA A 699
THR A 478
ALA A 668
 None
 1.19A 4oqrA-1rw9A:
undetectable		 4oqrA-1rw9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 THR A 669
ALA A 477
THR A 478
ALA A 479
 None
 0.82A 4qw0K-1rw9A:
undetectable		 4qw0K-1rw9A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 THR A 669
ALA A 477
THR A 478
ALA A 479
 None
 0.82A 4qw0Y-1rw9A:
undetectable		 4qw0Y-1rw9A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 ALA A 275
ARG A 184
GLY A 181
THR A 178
 None
 1.02A 5bs8A-1rw9A:
undetectable
5bs8B-1rw9A:
undetectable
5bs8C-1rw9A:
undetectable		 5bs8A-1rw9A:
22.22
5bs8B-1rw9A:
17.95
5bs8C-1rw9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 5 THR A 610
ALA A 609
TYR A 573
HIS A 532
 None
 1.32A 5ecmA-1rw9A:
undetectable		 5ecmA-1rw9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 7 TYR A 406
GLY A 492
THR A 496
LEU A 457
 None
 1.02A 5esmA-1rw9A:
undetectable		 5esmA-1rw9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A 481
TYR A 626
ILE A 450
GLY A 422
HIS A 376
 None
 1.16A 5fsaB-1rw9A:
undetectable		 5fsaB-1rw9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 VAL A 359
LEU A 362
ILE A 285
ILE A 313
LEU A 431
 None
 1.18A 5hbsA-1rw9A:
undetectable		 5hbsA-1rw9A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 TRP A 474
GLU A 473
GLY A 683
PRO A 684
 None
 1.01A 5kgpA-1rw9A:
undetectable		 5kgpA-1rw9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 8 TRP A 474
GLU A 473
GLY A 683
PRO A 684
 None
 1.02A 5kgpB-1rw9A:
undetectable		 5kgpB-1rw9A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 5 ILE A 103
PHE A  61
SER A  47
ALA A 102
 None
 1.24A 5msdA-1rw9A:
undetectable		 5msdA-1rw9A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		3 / 3 GLN A 189
TRP A  16
VAL A 141
 None
 1.07A 6auuA-1rw9A:
3.3		 6auuA-1rw9A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 714
LEU A 698
LEU A 739
THR A 738
GLY A 683
 None
 1.00A 6b0cD-1rw9A:
undetectable		 6b0cD-1rw9A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1rw9 CHONDROITIN AC LYASE
(Paenarthrobacter
aurescens) 		4 / 6 VAL A  93
TRP A  86
ALA A  85
THR A  84
 None
 1.04A 6cduB-1rw9A:
2.5
6cduC-1rw9A:
3.5		 6cduB-1rw9A:
18.21
6cduC-1rw9A:
18.21