SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4004_1
(SERUM ALBUMIN)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		4 / 4 VAL A  49
PHE A  22
SER A  41
VAL A  39
 None
 1.43A 1e7cA-1rwlA:
undetectable		 1e7cA-1rwlA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  61
PRO A  62
LEU A  92
 None
 0.54A 1hrkA-1rwlA:
undetectable		 1hrkA-1rwlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 102
PRO A 103
LEU A 134
 None
 0.54A 1hrkA-1rwlA:
undetectable		 1hrkA-1rwlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 228
PRO A 229
ARG A 245
 None
 0.59A 2qd5A-1rwlA:
undetectable		 2qd5A-1rwlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		5 / 8 ASP A  32
GLY A  35
ASP A 242
LEU A  51
VAL A  80
 None
 1.38A 3em6A-1rwlA:
undetectable		 3em6A-1rwlA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		5 / 8 ASP A 116
GLY A 119
ASP A  75
LEU A 134
VAL A 163
 None
 1.34A 3em6A-1rwlA:
undetectable		 3em6A-1rwlA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		3 / 3 THR A 212
ASN A 211
GLU A 209
 None
 0.78A 3v4tA-1rwlA:
undetectable
3v4tC-1rwlA:
undetectable		 3v4tA-1rwlA:
22.73
3v4tC-1rwlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 228
PRO A 229
ARG A 245
 None
 0.62A 4klrB-1rwlA:
undetectable		 4klrB-1rwlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 1rwl SERINE/THREONINE-PRO
TEIN KINASE PKND
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 177
LYS A 175
ASN A 182
 None
 0.93A 4y1dA-1rwlA:
undetectable
4y1dD-1rwlA:
undetectable		 4y1dA-1rwlA:
21.89
4y1dD-1rwlA:
4.35