SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 5 ARG A 242
ALA A 262
ASP A 218
GLY A 240
 None
 0.95A 1e7bA-1rwrA:
undetectable		 1e7bA-1rwrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 8 GLY A 171
GLY A 223
ALA A 172
LEU A 247
ILE A 184
 None
 1.05A 1yajC-1rwrA:
undetectable		 1yajC-1rwrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.05A 2bm9A-1rwrA:
undetectable		 2bm9A-1rwrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.29A 2bm9B-1rwrA:
undetectable		 2bm9B-1rwrA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.08A 2br4A-1rwrA:
undetectable		 2br4A-1rwrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.07A 2br4D-1rwrA:
undetectable		 2br4D-1rwrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 LEU A 273
LEU A 275
GLY A 264
SER A 282
ALA A 224
 None
 1.11A 2br4F-1rwrA:
undetectable		 2br4F-1rwrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 8 SER A 174
ALA A 182
PHE A 160
LEU A 124
 None
 0.89A 2bxmA-1rwrA:
undetectable		 2bxmA-1rwrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 THR A 123
THR A 125
LEU A  77
ILE A 136
LEU A  88
 None
 1.36A 3gwxB-1rwrA:
undetectable		 3gwxB-1rwrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 11 LEU A 232
GLY A 219
ILE A 261
VAL A 173
GLY A 245
 None
 1.13A 3zosA-1rwrA:
undetectable
3zosB-1rwrA:
undetectable		 3zosA-1rwrA:
21.70
3zosB-1rwrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 8 ALA A  73
GLY A  96
VAL A  21
ILE A  23
 None
 0.75A 4ll3A-1rwrA:
undetectable		 4ll3A-1rwrA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 10 LEU A 122
LEU A 101
VAL A  41
LEU A   3
VAL A  11
 None
 0.93A 4po0A-1rwrA:
undetectable		 4po0A-1rwrA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 8 PHE A  39
ARG A  87
ALA A  89
LEU A  88
 None
 0.87A 4rkuA-1rwrA:
undetectable
4rkuJ-1rwrA:
0.0		 4rkuA-1rwrA:
17.91
4rkuJ-1rwrA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 9 PHE A 160
LEU A 157
VAL A 111
VAL A 152
LEU A  88
 None
 1.22A 4wnvA-1rwrA:
undetectable		 4wnvA-1rwrA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 7 PHE A  39
ARG A  87
ALA A  89
LEU A  88
 None
 0.90A 4xk8A-1rwrA:
undetectable		 4xk8A-1rwrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 8 PHE A  39
ARG A  87
ALA A  89
LEU A  88
 None
 0.89A 4xk8a-1rwrA:
undetectable		 4xk8a-1rwrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 11 GLY A 156
ALA A 154
PHE A 160
TYR A 159
ASN A 118
 None
 1.32A 5c8tB-1rwrA:
0.0		 5c8tB-1rwrA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 6 ASP A 218
ARG A 242
GLY A 240
GLU A 260
 None
 0.97A 5cdqA-1rwrA:
undetectable
5cdqC-1rwrA:
undetectable
5cdqD-1rwrA:
undetectable		 5cdqA-1rwrA:
20.77
5cdqC-1rwrA:
20.77
5cdqD-1rwrA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 GLY A 151
LEU A 169
VAL A 111
VAL A 145
VAL A 162
 None
 1.14A 5dpdA-1rwrA:
undetectable		 5dpdA-1rwrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 GLY A 151
LEU A 169
VAL A 111
VAL A 145
VAL A 162
 None
 1.09A 5dpdB-1rwrA:
undetectable		 5dpdB-1rwrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 10 THR A 116
ALA A 154
THR A 155
SER A 175
ASP A 183
 None
 1.16A 5l66K-1rwrA:
undetectable
5l66L-1rwrA:
undetectable		 5l66K-1rwrA:
24.24
5l66L-1rwrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 10 THR A 116
ALA A 154
THR A 155
SER A 175
ASP A 183
 None
 1.17A 5l66Y-1rwrA:
undetectable
5l66Z-1rwrA:
undetectable		 5l66Y-1rwrA:
24.24
5l66Z-1rwrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		4 / 4 LEU A 181
GLY A 227
SER A 249
SER A 251
 None
 1.36A 5uunA-1rwrA:
undetectable		 5uunA-1rwrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		3 / 3 GLY A  90
ASN A  43
ARG A  87
 None
 0.65A 5w7bD-1rwrA:
undetectable		 5w7bD-1rwrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 PHE A  39
ALA A  75
ALA A  99
ILE A  59
LEU A  92
 None
 1.19A 6aybA-1rwrA:
undetectable		 6aybA-1rwrA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		3 / 3 SER A 257
SER A 234
ALA A 214
 None
 0.67A 6dwnC-1rwrA:
undetectable		 6dwnC-1rwrA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 1rwr FILAMENTOUS
HEMAGGLUTININ
(Bordetella
pertussis) 		5 / 12 VAL A 131
THR A 116
HIS A  33
PRO A  19
GLY A  30
 None
 0.94A 6gngB-1rwrA:
undetectable		 6gngB-1rwrA:
21.54