SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 189
GLY A 243
PHE A 244
GLY A 241
 None
 0.73A 1jhqA-1rx0A:
undetectable		 1jhqA-1rx0A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLU A 199
HIS A 104
LEU A 127
PRO A 126
ALA A 134
 None
 1.41A 1mjqC-1rx0A:
undetectable
1mjqD-1rx0A:
undetectable		 1mjqC-1rx0A:
14.25
1mjqD-1rx0A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 SER A 218
GLY A 215
GLU A  49
SER A  96
ASP A 368
 None
 1.21A 1pk7A-1rx0A:
undetectable		 1pk7A-1rx0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 SER A 218
GLY A 215
GLU A  49
SER A  96
ASP A 368
 None
 1.20A 1pk7C-1rx0A:
undetectable		 1pk7C-1rx0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 SER A 218
GLY A 215
GLU A  49
SER A  96
ASP A 368
 None
 1.18A 1pk9A-1rx0A:
undetectable		 1pk9A-1rx0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 SER A 218
GLY A 215
GLU A  49
SER A  96
ASP A 368
 None
 1.20A 1pk9B-1rx0A:
undetectable		 1pk9B-1rx0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 SER A 218
GLY A 215
GLU A  49
SER A  96
ASP A 368
 None
 1.18A 1pk9C-1rx0A:
undetectable		 1pk9C-1rx0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 SER A 218
GLY A 215
GLU A  49
SER A  96
ASP A 368
 None
 1.19A 1pw7A-1rx0A:
undetectable		 1pw7A-1rx0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PRO A 125
ILE A 111
ARG A 120
ASP A 112
 None
 1.43A 2rhmB-1rx0A:
undetectable		 2rhmB-1rx0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PRO A 125
ILE A 111
ARG A 120
ASP A 112
 None
 1.49A 2rhmD-1rx0A:
undetectable		 2rhmD-1rx0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A  65
TYR A  68
GLY A  75
ASN A 105
 None
 1.05A 3e9rA-1rx0A:
undetectable		 3e9rA-1rx0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A  65
TYR A  68
GLY A  75
ASN A 105
 None
 1.08A 3e9rC-1rx0A:
undetectable		 3e9rC-1rx0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LYS A 132
VAL A 181
MET A 110
ILE A 196
 None
 0.90A 3gp0A-1rx0A:
undetectable		 3gp0A-1rx0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 178
ILE A  69
THR A 129
VAL A  73
GLY A  74
 None
 0.93A 3kw4A-1rx0A:
0.0		 3kw4A-1rx0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ALA A  34
GLY A  93
THR A  92
THR A  98
 None
None
EDO  A2001 ( 4.6A)
None
 0.81A 3rglA-1rx0A:
undetectable		 3rglA-1rx0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A  67
ILE A  86
SER A 102
ALA A  91
 None
 0.96A 4eyzA-1rx0A:
undetectable		 4eyzA-1rx0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A  67
ILE A  86
SER A 102
ALA A  91
 None
 0.94A 4eyzB-1rx0A:
undetectable		 4eyzB-1rx0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A  52
VAL A  55
MET A  56
ALA A  59
 None
 1.15A 4lb2A-1rx0A:
0.2		 4lb2A-1rx0A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A  63
GLY A  74
ILE A  69
LEU A 127
 None
 0.85A 4mwzB-1rx0A:
0.0		 4mwzB-1rx0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A  13
ARG A 303
THR A 296
LEU A 297
 None
 0.99A 5b3sA-1rx0A:
undetectable
5b3sJ-1rx0A:
undetectable		 5b3sA-1rx0A:
22.81
5b3sJ-1rx0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 236
ILE A 196
SER A 194
 EDO  A2011 (-3.1A)
None
None
 0.79A 5zw2A-1rx0A:
53.3		 5zw2A-1rx0A:
29.19