SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  67
ILE A  27
MET A  71
LEU A  97
LEU A  11
 None
 1.03A 1bsxA-1rxmA:
undetectable		 1bsxA-1rxmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  67
ILE A  27
MET A  71
LEU A  97
LEU A  11
 None
 1.03A 1bsxB-1rxmA:
undetectable		 1bsxB-1rxmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 7 LEU A 227
ILE A  74
THR A  15
MET A  71
 None
 1.26A 1kglA-1rxmA:
2.2		 1kglA-1rxmA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 6 VAL A  14
THR A  13
GLU A   9
ARG A 231
 None
 1.12A 1s8fB-1rxmA:
undetectable		 1s8fB-1rxmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 209
ILE A  51
VAL A  47
 None
 0.67A 2avvD-1rxmA:
undetectable		 2avvD-1rxmA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 7 LEU A  11
VAL A  14
THR A  15
VAL A  69
 None
 0.84A 2qblA-1rxmA:
undetectable		 2qblA-1rxmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		5 / 9 THR A  13
VAL A 228
GLY A 206
PHE A 225
GLU A 226
 None
 1.31A 2w98A-1rxmA:
undetectable		 2w98A-1rxmA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 6 HIS A  35
ASP A  40
TYR A 236
HIS A  28
 None
 1.38A 2zxwN-1rxmA:
undetectable
2zxwP-1rxmA:
undetectable		 2zxwN-1rxmA:
19.33
2zxwP-1rxmA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 8 GLY A 160
GLU A 180
ILE A 131
ALA A 129
 None
 0.92A 3aodA-1rxmA:
undetectable		 3aodA-1rxmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 8 ILE A  27
LEU A  34
PHE A  29
LEU A  11
 None
 0.92A 3asoN-1rxmA:
undetectable
3asoW-1rxmA:
undetectable		 3asoN-1rxmA:
19.33
3asoW-1rxmA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 6 GLY A 187
GLY A 186
SER A 156
LEU A 181
 None
 0.78A 3o9mB-1rxmA:
undetectable		 3o9mB-1rxmA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EVY_X_SALX502_1
(SALICYLATE
HYDROXYLASE)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 5 SER A 156
MET A 133
LEU A 181
PHE A 184
 None
 1.21A 5evyX-1rxmA:
0.0		 5evyX-1rxmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		5 / 12 PHE A  29
LEU A  11
PRO A  52
GLY A  33
ILE A  27
 None
 1.29A 5tuiB-1rxmA:
undetectable		 5tuiB-1rxmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rxm DNA POLYMERASE
SLIDING CLAMP
(Archaeoglobus
fulgidus) 		4 / 5 ARG A 162
MET A 176
THR A 177
LEU A 181
 None
 1.32A 5x1bJ-1rxmA:
undetectable		 5x1bJ-1rxmA:
12.24