SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rxq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IBG_H_OBNH1_2 (IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN) IGG2B-KAPPA 40-50 FAB (LIGHT CHAIN))	1rxq	YFIT (Bacillus subtilis)	4 / 7	SER A 110 HIS A 66 SER A 104 ARG A 62	None	1.07A	1ibgL-1rxqA: undetectable	1ibgL-1rxqA: 22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZX_X_T3X500_2 (THYROID HORMONE RECEPTOR BETA-1)	1rxq	YFIT (Bacillus subtilis)	3 / 3	PHE A 79 ARG A 91 ASN A 74	None	0.93A	1xzxX-1rxqA: undetectable	1xzxX-1rxqA: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_A_CUA517_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	1rxq	YFIT (Bacillus subtilis)	3 / 3	HIS A 67 HIS A 160 HIS A 164	NI A 300 (-3.3A) NI A 300 (-3.3A) NI A 300 (-3.3A)	0.75A	3ag4A-1rxqA: undetectable	3ag4A-1rxqA: 14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_A_ACTA500_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	1rxq	YFIT (Bacillus subtilis)	4 / 4	ALA A 166 HIS A 167 HIS A 163 PRO A 9	None	1.11A	3mbgA-1rxqA: 2.1	3mbgA-1rxqA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC900_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	1rxq	YFIT (Bacillus subtilis)	4 / 4	ALA A 166 HIS A 167 HIS A 163 PRO A 9	None	1.13A	3mbgC-1rxqA: 2.1	3mbgC-1rxqA: 19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PAH_A_LNRA600_1 (PHENYLALANINE HYDROXYLASE)	1rxq	YFIT (Bacillus subtilis)	4 / 6	LEU A 156 HIS A 67 TYR A 93 GLU A 95	None NI A 300 (-3.3A) None NI A 300 ( 4.1A)	0.86A	4pahA-1rxqA: undetectable	4pahA-1rxqA: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GIQ_A_CUA601_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	1rxq	YFIT (Bacillus subtilis)	3 / 3	HIS A 67 HIS A 160 HIS A 164	NI A 300 (-3.3A) NI A 300 (-3.3A) NI A 300 (-3.3A)	0.58A	6giqa-1rxqA: 2.1	6giqa-1rxqA: 14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6PAH_A_DAHA600_1 (PHENYLALANINE 4-MONOOXYGENASE)	1rxq	YFIT (Bacillus subtilis)	4 / 6	LEU A 156 HIS A 67 TYR A 93 GLU A 95	None NI A 300 (-3.3A) None NI A 300 ( 4.1A)	0.92A	6pahA-1rxqA: undetectable	6pahA-1rxqA: 20.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IBG_H_OBNH1_2","IGG2B-KAPPA 40-50 FAB (HEAVY CHAIN);IGG2B-KAPPA 40-50 FAB (LIGHT CHAIN)","1rxq","YFIT","Bacillus subtilis",4,"SER A 110;HIS A  66;SER A 104;ARG A  62","None","1.07A","1ibgL-1rxqA:undetectable","1ibgL-1rxqA:22.07"],["1XZX_X_T3X500_2","THYROID HORMONE RECEPTOR BETA-1","1rxq","YFIT","Bacillus subtilis",3,"PHE A  79;ARG A  91;ASN A  74","None","0.93A","1xzxX-1rxqA:undetectable","1xzxX-1rxqA:21.65"],["3AG4_A_CUA517_0","CYTOCHROME C OXIDASE SUBUNIT 1","1rxq","YFIT","Bacillus subtilis",3,"HIS A  67;HIS A 160;HIS A 164"," NI A 300 (-3.3A); NI A 300 (-3.3A); NI A 300 (-3.3A)","0.75A","3ag4A-1rxqA:undetectable","3ag4A-1rxqA:14.20"],["3MBG_A_ACTA500_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","1rxq","YFIT","Bacillus subtilis",4,"ALA A 166;HIS A 167;HIS A 163;PRO A   9","None","1.11A","3mbgA-1rxqA:2.1","3mbgA-1rxqA:19.89"],["3MBG_C_ACTC900_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","1rxq","YFIT","Bacillus subtilis",4,"ALA A 166;HIS A 167;HIS A 163;PRO A   9","None","1.13A","3mbgC-1rxqA:2.1","3mbgC-1rxqA:19.89"],["4PAH_A_LNRA600_1","PHENYLALANINE HYDROXYLASE","1rxq","YFIT","Bacillus subtilis",4,"LEU A 156;HIS A  67;TYR A  93;GLU A  95","None; NI A 300 (-3.3A);None; NI A 300 ( 4.1A)","0.86A","4pahA-1rxqA:undetectable","4pahA-1rxqA:20.13"],["6GIQ_A_CUA601_0","CYTOCHROME C OXIDASE SUBUNIT 1","1rxq","YFIT","Bacillus subtilis",3,"HIS A  67;HIS A 160;HIS A 164"," NI A 300 (-3.3A); NI A 300 (-3.3A); NI A 300 (-3.3A)","0.58A","6giqa-1rxqA:2.1","6giqa-1rxqA:14.61"],["6PAH_A_DAHA600_1","PHENYLALANINE 4-MONOOXYGENASE","1rxq","YFIT","Bacillus subtilis",4,"LEU A 156;HIS A  67;TYR A  93;GLU A  95","None; NI A 300 (-3.3A);None; NI A 300 ( 4.1A)","0.92A","6pahA-1rxqA:undetectable","6pahA-1rxqA:20.13"]]