SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		5 / 12 PHE A 407
PHE A 413
LEU A 411
ALA A 388
PHE A 396
 None
 1.45A 3apwB-1rxtA:
undetectable		 3apwB-1rxtA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		3 / 3 CYH A 135
HIS A 134
PHE A 148
 None
 1.20A 3cr4X-1rxtA:
undetectable		 3cr4X-1rxtA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		3 / 3 THR A 313
SER A 328
PHE A 393
 None
 0.80A 3d4sA-1rxtA:
undetectable		 3d4sA-1rxtA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		4 / 6 SER A 350
PHE A 396
PHE A 407
ASN A 404
 None
 1.00A 3lskB-1rxtA:
0.6		 3lskB-1rxtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		4 / 6 SER A 350
PHE A 396
PHE A 407
ASN A 404
 None
 1.02A 3lskD-1rxtA:
undetectable		 3lskD-1rxtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		4 / 7 ILE A 158
LEU A 424
THR A 286
ILE A 452
 None
 0.98A 3p50E-1rxtA:
undetectable		 3p50E-1rxtA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		3 / 3 LEU A 387
MET A 381
ASP A 325
 None
 0.84A 3v5wA-1rxtA:
undetectable		 3v5wA-1rxtA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		4 / 5 THR A 286
ILE A 452
GLU A 167
PHE A 351
 None
 1.16A 4acbC-1rxtA:
undetectable		 4acbC-1rxtA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		5 / 12 CYH A 172
GLY A 207
SER A 150
GLY A 147
LEU A  98
 None
 1.06A 4fp9A-1rxtA:
undetectable		 4fp9A-1rxtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		5 / 12 CYH A 172
GLY A 207
SER A 150
GLY A 147
LEU A  98
 None
 1.09A 4fzvA-1rxtA:
undetectable		 4fzvA-1rxtA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		4 / 8 PHE A 351
TRP A 122
ASN A 169
ILE A 156
 None
 0.88A 4qoiA-1rxtA:
0.0
4qoiB-1rxtA:
0.0		 4qoiA-1rxtA:
18.35
4qoiB-1rxtA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		4 / 6 TYR A 330
TYR A 115
LEU A 120
PHE A 170
 None
 1.19A 4twdD-1rxtA:
undetectable
4twdE-1rxtA:
undetectable		 4twdD-1rxtA:
20.48
4twdE-1rxtA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		4 / 6 TYR A 330
TYR A 115
LEU A 120
PHE A 170
 None
 0.98A 4twdI-1rxtA:
0.0
4twdJ-1rxtA:
0.0		 4twdI-1rxtA:
20.48
4twdJ-1rxtA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		5 / 11 PHE A 111
VAL A 395
ASP A 394
PHE A 234
SER A 334
 None
 1.07A 4xp4A-1rxtA:
undetectable		 4xp4A-1rxtA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens) 		5 / 8 LEU A 261
GLY A 260
VAL A 316
LEU A 327
MET A 381
 None
 1.04A 4zauA-1rxtA:
undetectable		 4zauA-1rxtA:
21.24