SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 185
TYR A 173
LYS A   3
 None
 0.85A 1uujB-1rxwA:
0.0		 1uujB-1rxwA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 147
ILE A 143
VAL A 165
 None
 0.66A 2avvD-1rxwA:
undetectable		 2avvD-1rxwA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		5 / 9 GLU A 207
LEU A 225
LEU A 176
ARG A 185
ALA A   3
 None
 1.45A 2bxcB-1rxwA:
undetectable		 2bxcB-1rxwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 289
ASP A 147
ASP A  80
 None
 0.81A 2ejtA-1rxwA:
undetectable		 2ejtA-1rxwA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		4 / 5 ALA A 261
ILE A 252
ILE A 230
ASP A 227
 None
 1.06A 2h4jA-1rxwA:
2.1		 2h4jA-1rxwA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		4 / 6 ARG A 185
GLN A 171
ASN A  30
ASN A  67
 None
 1.25A 2nyrA-1rxwA:
2.5		 2nyrA-1rxwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		5 / 12 PRO A 295
ILE A  61
THR A  31
VAL A  26
PRO A  75
 None
 1.23A 3a51B-1rxwA:
0.0		 3a51B-1rxwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		4 / 8 LEU A  32
THR A  31
GLY A 169
ILE A 143
 None
 0.83A 3jusB-1rxwA:
undetectable		 3jusB-1rxwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		4 / 4 ASP A 235
ASP A 174
GLY A 152
THR A 168
 None
 1.33A 3tl9B-1rxwA:
undetectable		 3tl9B-1rxwA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 113
LYS A 114
ASP A 115
 None
 0.77A 4a7tA-1rxwA:
undetectable		 4a7tA-1rxwA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A  86
ASP A 235
ASP A  27
GLY A 152
SER A 150
 None
 1.31A 4djeA-1rxwA:
undetectable		 4djeA-1rxwA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A 308
LEU A 319
LEU A  62
LEU A 137
THR A 136
 None
 0.92A 4k13A-1rxwA:
undetectable		 4k13A-1rxwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		5 / 11 ASP A  27
ALA A 161
SER A 175
SER A 180
GLY A 179
 None
 1.27A 4mmaA-1rxwA:
0.0		 4mmaA-1rxwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 260
ILE A 258
PHE A 259
 None
 0.70A 5kirA-1rxwA:
undetectable		 5kirA-1rxwA:
21.43