SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ry2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.01A 1c9hA-1ry2A:
undetectable		 1c9hA-1ry2A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.36A 1c9sA-1ry2A:
undetectable
1c9sK-1ry2A:
undetectable		 1c9sA-1ry2A:
7.99
1c9sK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.33A 1c9sB-1ry2A:
undetectable
1c9sC-1ry2A:
undetectable		 1c9sB-1ry2A:
7.99
1c9sC-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 1c9sC-1ry2A:
undetectable
1c9sD-1ry2A:
undetectable		 1c9sC-1ry2A:
7.99
1c9sD-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.33A 1c9sE-1ry2A:
undetectable
1c9sF-1ry2A:
undetectable		 1c9sE-1ry2A:
7.99
1c9sF-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 1c9sF-1ry2A:
undetectable
1c9sG-1ry2A:
undetectable		 1c9sF-1ry2A:
7.99
1c9sG-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.03A 1fapA-1ry2A:
undetectable		 1fapA-1ry2A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.08A 1fkfA-1ry2A:
undetectable		 1fkfA-1ry2A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.10A 1fkjA-1ry2A:
undetectable		 1fkjA-1ry2A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.11A 1fklA-1ry2A:
undetectable		 1fklA-1ry2A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.33A 1gtfB-1ry2A:
0.0
1gtfC-1ry2A:
undetectable		 1gtfB-1ry2A:
7.99
1gtfC-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.36A 1gtfC-1ry2A:
undetectable
1gtfD-1ry2A:
undetectable		 1gtfC-1ry2A:
7.99
1gtfD-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.35A 1gtfE-1ry2A:
undetectable
1gtfF-1ry2A:
undetectable		 1gtfE-1ry2A:
7.99
1gtfF-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.35A 1gtnG-1ry2A:
undetectable
1gtnH-1ry2A:
undetectable		 1gtnG-1ry2A:
7.99
1gtnH-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 667
GLU A 603
GLU A 592
GLU A 444
 None
 1.16A 1knyA-1ry2A:
undetectable
1knyB-1ry2A:
undetectable		 1knyA-1ry2A:
16.19
1knyB-1ry2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 265
ARG A 289
ASP A 290
THR A 242
 None
 1.25A 1rrjA-1ry2A:
0.0		 1rrjA-1ry2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 255
VAL A 272
VAL A 274
ARG A 289
ASP A 290
 None
 1.37A 1t6zA-1ry2A:
2.2		 1t6zA-1ry2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 0.99A 1tcoC-1ry2A:
undetectable		 1tcoC-1ry2A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 662
LEU A 668
LEU A 624
VAL A 601
ALA A 602
 None
 1.14A 1tsnA-1ry2A:
0.0		 1tsnA-1ry2A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 503
TYR A 469
ILE A 569
ASP A 559
 None
AMP  A 720 (-4.8A)
None
AMP  A 720 (-2.2A)
 1.13A 1upfC-1ry2A:
3.2		 1upfC-1ry2A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.32A 1utdD-1ry2A:
undetectable
1utdE-1ry2A:
undetectable		 1utdD-1ry2A:
7.99
1utdE-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.33A 1utdA-1ry2A:
undetectable
1utdK-1ry2A:
undetectable		 1utdA-1ry2A:
7.99
1utdK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 596
LEU A 668
ALA A 605
GLU A 592
 None
 1.29A 1xvaA-1ry2A:
3.5
1xvaB-1ry2A:
undetectable		 1xvaA-1ry2A:
18.82
1xvaB-1ry2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 365
THR A 359
TYR A 411
 None
 1.06A 2a3aB-1ry2A:
undetectable		 2a3aB-1ry2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 365
THR A 359
TYR A 411
 None
 1.13A 2a3bA-1ry2A:
undetectable		 2a3bA-1ry2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.07A 2fkeA-1ry2A:
undetectable		 2fkeA-1ry2A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 467
SER A 441
GLY A 443
ARG A 418
 AMP  A 720 (-3.4A)
None
AMP  A 720 (-3.9A)
None
 1.23A 2j2pA-1ry2A:
undetectable
2j2pB-1ry2A:
undetectable		 2j2pA-1ry2A:
15.13
2j2pB-1ry2A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 571
GLY A 558
GLY A 560
THR A 546
PHE A 532
 AMP  A 720 (-3.9A)
None
None
None
None
 1.13A 2okcA-1ry2A:
undetectable		 2okcA-1ry2A:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 5 THR A 367
VAL A 442
GLY A 443
TRP A 470
 None
AMP  A 720 ( 4.7A)
AMP  A 720 (-3.9A)
None
 0.38A 2p2fA-1ry2A:
55.0		 2p2fA-1ry2A:
45.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 156
ASN A 247
THR A 255
 None
 0.70A 2pymB-1ry2A:
undetectable		 2pymB-1ry2A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 156
ASN A 247
THR A 255
 None
 0.69A 2q63B-1ry2A:
undetectable		 2q63B-1ry2A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 530
SER A 531
VAL A 108
TRP A 125
 None
 0.90A 2qd3A-1ry2A:
4.4		 2qd3A-1ry2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 366
VAL A 442
GLY A 443
THR A 472
 AMP  A 720 (-4.9A)
AMP  A 720 ( 4.7A)
AMP  A 720 (-3.9A)
AMP  A 720 (-3.6A)
 0.71A 2wd9A-1ry2A:
42.5		 2wd9A-1ry2A:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 8 ILE A 366
VAL A 442
GLY A 443
GLN A 471
THR A 472
 AMP  A 720 (-4.9A)
AMP  A 720 ( 4.7A)
AMP  A 720 (-3.9A)
AMP  A 720 (-4.4A)
AMP  A 720 (-3.6A)
 0.75A 2wd9B-1ry2A:
41.8		 2wd9B-1ry2A:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		6 / 10 THR A 320
ILE A 366
VAL A 442
GLY A 443
GLN A 471
THR A 472
 AMP  A 720 ( 4.8A)
AMP  A 720 (-4.9A)
AMP  A 720 ( 4.7A)
AMP  A 720 (-3.9A)
AMP  A 720 (-4.4A)
AMP  A 720 (-3.6A)
 0.90A 2wd9C-1ry2A:
41.7		 2wd9C-1ry2A:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 369
TYR A 374
LEU A 377
ILE A 164
HIS A 216
 None
 1.28A 2xkwA-1ry2A:
0.0		 2xkwA-1ry2A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 372
ARG A 248
ILE A 401
THR A 367
 None
 1.05A 3cl9A-1ry2A:
undetectable		 3cl9A-1ry2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 235
LEU A 206
SER A 321
VAL A 194
ILE A 363
 None
 1.06A 3frqB-1ry2A:
undetectable		 3frqB-1ry2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.06A 3ihzA-1ry2A:
undetectable		 3ihzA-1ry2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 135
CYH A 137
ASN A 136
THR A 145
 None
 1.06A 3lm8B-1ry2A:
undetectable
3lm8D-1ry2A:
2.8		 3lm8B-1ry2A:
17.35
3lm8D-1ry2A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 454
LEU A 433
VAL A 407
ALA A 360
PHE A 358
 None
 1.45A 3nuvA-1ry2A:
0.0		 3nuvA-1ry2A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 0.99A 3o5rA-1ry2A:
undetectable		 3o5rA-1ry2A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 511
GLU A 513
GLY A 521
ALA A 524
ASP A 559
 None
None
None
None
AMP  A 720 (-2.2A)
 1.30A 3qowA-1ry2A:
4.6		 3qowA-1ry2A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 176
VAL A 194
MET A 196
ILE A 209
 None
 0.82A 3remA-1ry2A:
undetectable		 3remA-1ry2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 176
VAL A 194
MET A 196
ILE A 209
 None
 0.83A 3remB-1ry2A:
undetectable		 3remB-1ry2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_2
(NEURAMINIDASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 577
ARG A 678
ARG A 682
ILE A 676
 None
 1.48A 3sanA-1ry2A:
undetectable		 3sanA-1ry2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.07A 3uf8A-1ry2A:
undetectable		 3uf8A-1ry2A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.07A 3uqaA-1ry2A:
undetectable		 3uqaA-1ry2A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 218
HIS A 369
PHE A 220
PRO A 327
 None
 1.20A 3v35A-1ry2A:
undetectable		 3v35A-1ry2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.07A 3vawA-1ry2A:
undetectable		 3vawA-1ry2A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.17A 4drhA-1ry2A:
undetectable		 4drhA-1ry2A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.12A 4drhD-1ry2A:
undetectable		 4drhD-1ry2A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.08A 4driA-1ry2A:
undetectable		 4driA-1ry2A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.08A 4drjA-1ry2A:
undetectable		 4drjA-1ry2A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.05A 4dz2A-1ry2A:
undetectable
4dz2B-1ry2A:
undetectable		 4dz2A-1ry2A:
9.59
4dz2B-1ry2A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.03A 4dz2A-1ry2A:
undetectable
4dz2B-1ry2A:
undetectable		 4dz2A-1ry2A:
9.59
4dz2B-1ry2A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.04A 4dz3A-1ry2A:
undetectable		 4dz3A-1ry2A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.02A 4dz3B-1ry2A:
undetectable		 4dz3B-1ry2A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 674
SER A 673
TRP A 365
 None
 0.88A 4e7cD-1ry2A:
0.0		 4e7cD-1ry2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 232
LEU A 228
ALA A 193
VAL A 192
 None
 0.55A 4g77A-1ry2A:
undetectable		 4g77A-1ry2A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 685
GLY A 608
ALA A 619
LEU A 668
ILE A 663
 None
 1.21A 4hytA-1ry2A:
4.3		 4hytA-1ry2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 685
GLY A 608
ALA A 619
LEU A 668
ILE A 663
 None
 1.21A 4hytC-1ry2A:
undetectable		 4hytC-1ry2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 530
SER A 531
VAL A 108
TRP A 125
 None
 0.90A 4kmmA-1ry2A:
0.0		 4kmmA-1ry2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.11A 4laxA-1ry2A:
undetectable		 4laxA-1ry2A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 375
THR A 359
TYR A 371
PHE A 357
 None
 1.02A 4m5mA-1ry2A:
undetectable		 4m5mA-1ry2A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.06A 4nnrA-1ry2A:
undetectable
4nnrB-1ry2A:
undetectable		 4nnrA-1ry2A:
12.82
4nnrB-1ry2A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.06A 4nnrB-1ry2A:
undetectable		 4nnrB-1ry2A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.12A 4qt2A-1ry2A:
undetectable		 4qt2A-1ry2A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.13A 4qt3A-1ry2A:
undetectable		 4qt3A-1ry2A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 193
VAL A 239
GLY A 268
THR A 266
 None
 1.14A 4ubeA-1ry2A:
4.8		 4ubeA-1ry2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 332
SER A 474
GLY A 329
PHE A 316
GLY A 364
 None
 1.30A 4uinH-1ry2A:
undetectable
4uinL-1ry2A:
undetectable		 4uinH-1ry2A:
17.33
4uinL-1ry2A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 155
GLN A 160
TYR A 162
PHE A 153
 None
 1.04A 4wryA-1ry2A:
undetectable		 4wryA-1ry2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.19A 5b8iC-1ry2A:
undetectable		 5b8iC-1ry2A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 SER A 321
THR A 320
ALA A 326
GLY A 325
THR A 324
 None
AMP  A 720 ( 4.8A)
None
None
None
 1.33A 5bxnV-1ry2A:
undetectable
5bxnW-1ry2A:
undetectable		 5bxnV-1ry2A:
16.16
5bxnW-1ry2A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.33A 5eeuA-1ry2A:
undetectable
5eeuB-1ry2A:
undetectable		 5eeuA-1ry2A:
7.99
5eeuB-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5eeuD-1ry2A:
undetectable
5eeuE-1ry2A:
undetectable		 5eeuD-1ry2A:
7.99
5eeuE-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.34A 5eeuA-1ry2A:
undetectable
5eeuK-1ry2A:
undetectable		 5eeuA-1ry2A:
7.99
5eeuK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5eevD-1ry2A:
undetectable
5eevE-1ry2A:
undetectable		 5eevD-1ry2A:
7.99
5eevE-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.34A 5eevA-1ry2A:
undetectable
5eevK-1ry2A:
undetectable		 5eevA-1ry2A:
7.99
5eevK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5eewD-1ry2A:
undetectable
5eewE-1ry2A:
undetectable		 5eewD-1ry2A:
7.99
5eewE-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5eewA-1ry2A:
undetectable
5eewK-1ry2A:
undetectable		 5eewA-1ry2A:
7.99
5eewK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5eexD-1ry2A:
undetectable
5eexE-1ry2A:
undetectable		 5eexD-1ry2A:
7.99
5eexE-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.36A 5eexI-1ry2A:
undetectable
5eexJ-1ry2A:
undetectable		 5eexI-1ry2A:
7.99
5eexJ-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5eexA-1ry2A:
undetectable
5eexK-1ry2A:
undetectable		 5eexA-1ry2A:
7.99
5eexK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5eeyD-1ry2A:
undetectable
5eeyE-1ry2A:
undetectable		 5eeyD-1ry2A:
7.99
5eeyE-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.36A 5eeyI-1ry2A:
undetectable
5eeyJ-1ry2A:
undetectable		 5eeyI-1ry2A:
7.99
5eeyJ-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5eeyA-1ry2A:
undetectable
5eeyK-1ry2A:
undetectable		 5eeyA-1ry2A:
7.99
5eeyK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5eezD-1ry2A:
undetectable
5eezE-1ry2A:
undetectable		 5eezD-1ry2A:
7.99
5eezE-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.36A 5eezI-1ry2A:
undetectable
5eezJ-1ry2A:
undetectable		 5eezI-1ry2A:
7.99
5eezJ-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5eezA-1ry2A:
undetectable
5eezK-1ry2A:
undetectable		 5eezA-1ry2A:
7.99
5eezK-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5ef0D-1ry2A:
undetectable
5ef0E-1ry2A:
undetectable		 5ef0D-1ry2A:
7.99
5ef0E-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.36A 5ef0I-1ry2A:
undetectable
5ef0J-1ry2A:
undetectable		 5ef0I-1ry2A:
7.99
5ef0J-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5ef0A-1ry2A:
undetectable
5ef0K-1ry2A:
undetectable		 5ef0A-1ry2A:
7.99
5ef0K-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5ef1D-1ry2A:
undetectable
5ef1E-1ry2A:
undetectable		 5ef1D-1ry2A:
7.99
5ef1E-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.37A 5ef1I-1ry2A:
undetectable
5ef1J-1ry2A:
undetectable		 5ef1I-1ry2A:
7.99
5ef1J-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5ef1A-1ry2A:
undetectable
5ef1K-1ry2A:
undetectable		 5ef1A-1ry2A:
7.99
5ef1K-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5ef2D-1ry2A:
undetectable
5ef2E-1ry2A:
undetectable		 5ef2D-1ry2A:
7.99
5ef2E-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.36A 5ef2I-1ry2A:
undetectable
5ef2J-1ry2A:
undetectable		 5ef2I-1ry2A:
7.99
5ef2J-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5ef2A-1ry2A:
undetectable
5ef2K-1ry2A:
undetectable		 5ef2A-1ry2A:
7.99
5ef2K-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.31A 5ef3D-1ry2A:
undetectable
5ef3E-1ry2A:
undetectable		 5ef3D-1ry2A:
7.99
5ef3E-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.37A 5ef3I-1ry2A:
undetectable
5ef3J-1ry2A:
0.0		 5ef3I-1ry2A:
7.99
5ef3J-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 477
THR A 370
ILE A 366
THR A 344
SER A 531
 None
None
AMP  A 720 (-4.9A)
None
None
 1.35A 5ef3A-1ry2A:
undetectable
5ef3K-1ry2A:
undetectable		 5ef3A-1ry2A:
7.99
5ef3K-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.04A 5hkgA-1ry2A:
undetectable		 5hkgA-1ry2A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.13A 5hw8A-1ry2A:
undetectable
5hw8D-1ry2A:
undetectable		 5hw8A-1ry2A:
10.61
5hw8D-1ry2A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.15A 5hw8D-1ry2A:
undetectable		 5hw8D-1ry2A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.17A 5hw8G-1ry2A:
undetectable		 5hw8G-1ry2A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.08A 5hwcA-1ry2A:
undetectable		 5hwcA-1ry2A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 133
ASN A 132
LEU A 131
 None
 0.47A 5i1oA-1ry2A:
undetectable		 5i1oA-1ry2A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 167
LEU A 207
ILE A 151
 None
 0.76A 5kc0A-1ry2A:
undetectable		 5kc0A-1ry2A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 255
SER A 246
ASP A 362
 None
 0.81A 5kvaA-1ry2A:
4.6		 5kvaA-1ry2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 THR A 255
SER A 246
ASP A 362
 None
 0.83A 5kvaB-1ry2A:
4.9		 5kvaB-1ry2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 MET A 184
LEU A 180
VAL A 192
ILE A 232
THR A 266
 None
 1.29A 5tiwB-1ry2A:
undetectable		 5tiwB-1ry2A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 417
VAL A 412
TYR A 454
ALA A 360
GLY A 361
 None
 1.14A 5tzoB-1ry2A:
undetectable		 5tzoB-1ry2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 492
THR A 344
PRO A 481
 None
 0.62A 5v5zA-1ry2A:
undetectable		 5v5zA-1ry2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 446
LEU A 439
PHE A 410
THR A 348
 None
 0.99A 5vc0A-1ry2A:
undetectable		 5vc0A-1ry2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 193
SER A 237
GLY A 235
TYR A 319
 None
 1.26A 5yodD-1ry2A:
undetectable		 5yodD-1ry2A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.14A 6mkeA-1ry2A:
undetectable
6mkeD-1ry2A:
undetectable		 6mkeA-1ry2A:
9.10
6mkeD-1ry2A:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.10A 6mkeB-1ry2A:
undetectable
6mkeC-1ry2A:
undetectable		 6mkeB-1ry2A:
9.10
6mkeC-1ry2A:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.05A 6mkeC-1ry2A:
undetectable		 6mkeC-1ry2A:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1ry2 ACETYL-COENZYME A
SYNTHETASE 1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
 None
 1.01A 6mkeD-1ry2A:
undetectable		 6mkeD-1ry2A:
9.10