SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ry6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		3 / 3 PHE A  89
LEU A 267
LEU A 288
 None
 0.67A 1mx1E-1ry6A:
undetectable		 1mx1E-1ry6A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		4 / 8 VAL A 291
ASP A 294
TYR A 144
LEU A 151
 None
 1.01A 1z2bB-1ry6A:
undetectable		 1z2bB-1ry6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		5 / 12 TYR A 144
ILE A 235
ASP A 294
ILE A 178
LEU A 176
 None
 1.17A 2jn3A-1ry6A:
undetectable		 2jn3A-1ry6A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		4 / 4 PRO A  10
ASP A  22
ASP A  35
ASP A  59
 None
 1.44A 2nyuA-1ry6A:
undetectable		 2nyuA-1ry6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		5 / 12 PHE A  89
ILE A 124
LEU A 187
ASN A 217
ILE A 232
 None
 1.31A 2ycjA-1ry6A:
undetectable		 2ycjA-1ry6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		5 / 12 TYR A 131
GLY A 230
GLY A  83
ASP A 294
SER A 228
 None
 1.28A 3dlcA-1ry6A:
undetectable		 3dlcA-1ry6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		3 / 3 LEU A 229
LEU A 220
ARG A 180
 None
 0.57A 3hcnB-1ry6A:
undetectable		 3hcnB-1ry6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		4 / 5 GLY A 104
PRO A 114
ASN A  64
TYR A 119
 None
 1.06A 3u8qA-1ry6A:
undetectable		 3u8qA-1ry6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		4 / 8 ILE A 295
PHE A 296
SER A 325
VAL A   4
 None
 0.80A 3ua5A-1ry6A:
undetectable		 3ua5A-1ry6A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		5 / 9 SER A  96
ALA A  90
LEU A 237
GLY A 239
ALA A 273
 SO4  A 401 (-3.6A)
None
None
None
None
 1.34A 4l6va-1ry6A:
0.0
4l6vf-1ry6A:
undetectable		 4l6va-1ry6A:
18.00
4l6vf-1ry6A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		5 / 12 ILE A 215
ALA A 214
ARG A 198
ALA A  90
LEU A 237
 None
 1.22A 4zo1X-1ry6A:
undetectable		 4zo1X-1ry6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		5 / 11 VAL A  54
VAL A   6
VAL A  57
ILE A  24
LEU A 322
 None
 0.97A 5e4dB-1ry6A:
undetectable		 5e4dB-1ry6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1ry6 INTERNAL KINESIN
(Plasmodium
falciparum) 		4 / 6 LEU A 176
LYS A 290
GLU A 287
LEU A 151
 None
 1.32A 5xooA-1ry6A:
undetectable		 5xooA-1ry6A:
13.64