SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ry9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Shigella
flexneri) 		5 / 12 ILE A  45
LEU A  37
ILE A  17
LEU A  14
PRO A  20
 None
 1.12A 1jolB-1ry9A:
undetectable		 1jolB-1ry9A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Shigella
flexneri) 		3 / 3 LEU A  88
LEU A  54
MET A  53
 None
 0.55A 2itzA-1ry9A:
undetectable		 2itzA-1ry9A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Shigella
flexneri) 		5 / 8 LEU A 119
VAL A 109
LEU A   9
ILE A 104
VAL A  52
 CL  A 303 ( 4.7A)
CL  A 301 (-4.7A)
None
None
None
 1.38A 3kp6A-1ry9A:
undetectable
3kp6B-1ry9A:
undetectable		 3kp6A-1ry9A:
22.89
3kp6B-1ry9A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Shigella
flexneri) 		4 / 7 VAL A 102
PHE A  81
PHE A 115
ILE A  45
 None
 0.88A 3zjqA-1ry9A:
undetectable		 3zjqA-1ry9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Shigella
flexneri) 		4 / 7 VAL A 102
PHE A  81
PHE A 115
ILE A  45
 None
 0.87A 3zjqB-1ry9A:
undetectable		 3zjqB-1ry9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1ry9 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Shigella
flexneri) 		3 / 3 THR A  34
ALA A  42
ASN A  44
 None
 0.60A 5ersA-1ry9A:
undetectable		 5ersA-1ry9A:
16.31