SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ryl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CEO_A_T44A1395_1 (THYROXINE-BINDING GLOBULIN)	1ryl	HYPOTHETICAL PROTEIN YFBM (Escherichia coli)	5 / 11	LEU A 34 LEU A 18 SER A 76 LEU A 77 LEU A 162	None	1.11A	2ceoA-1rylA: 0.0	2ceoA-1rylA: 16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CL9_A_MTXA602_2 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS))	1ryl	HYPOTHETICAL PROTEIN YFBM (Escherichia coli)	4 / 4	VAL A 71 ARG A 45 ILE A 122 THR A 163	None	1.21A	3cl9A-1rylA: undetectable	3cl9A-1rylA: 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_D_ACTD403_0 (D-ALANINE--D-ALANINE LIGASE)	1ryl	HYPOTHETICAL PROTEIN YFBM (Escherichia coli)	4 / 6	TYR A 6 GLY A 36 SER A 35 LEU A 34	None	1.30A	5bphD-1rylA: undetectable	5bphD-1rylA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	1ryl	HYPOTHETICAL PROTEIN YFBM (Escherichia coli)	5 / 12	PHE A 59 PHE A 84 THR A 163 SER A 76 GLY A 73	None	1.47A	5xioA-1rylA: undetectable	5xioA-1rylA: 17.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CEO_A_T44A1395_1","THYROXINE-BINDING GLOBULIN","1ryl","HYPOTHETICAL PROTEIN YFBM","Escherichia coli",5,"LEU A  34;LEU A  18;SER A  76;LEU A  77;LEU A 162","None","1.11A","2ceoA-1rylA:0.0","2ceoA-1rylA:16.22"],["3CL9_A_MTXA602_2","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)","1ryl","HYPOTHETICAL PROTEIN YFBM","Escherichia coli",4,"VAL A  71;ARG A  45;ILE A 122;THR A 163","None","1.21A","3cl9A-1rylA:undetectable","3cl9A-1rylA:16.06"],["5BPH_D_ACTD403_0","D-ALANINE--D-ALANINE LIGASE","1ryl","HYPOTHETICAL PROTEIN YFBM","Escherichia coli",4,"TYR A   6;GLY A  36;SER A  35;LEU A  34","None","1.30A","5bphD-1rylA:undetectable","5bphD-1rylA:21.82"],["5XIO_A_HFGA801_0","PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE)","1ryl","HYPOTHETICAL PROTEIN YFBM","Escherichia coli",5,"PHE A  59;PHE A  84;THR A 163;SER A  76;GLY A  73","None","1.47A","5xioA-1rylA:undetectable","5xioA-1rylA:17.51"]]