SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ryn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 10 ASP A  95
ASP A  94
VAL A  24
ILE A 137
GLY A 101
 ASP  A  95 ( 0.6A)
ASP  A  94 ( 0.6A)
VAL  A  24 ( 0.5A)
ILE  A 137 ( 0.6A)
GLY  A 101 ( 0.0A)
 1.19A 1d4sA-1rynA:
undetectable		 1d4sA-1rynA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 12 GLY A 136
SER A 139
ALA A 165
ASP A  95
ILE A 135
 GLY  A 136 ( 0.0A)
SER  A 139 ( 0.0A)
ALA  A 165 ( 0.0A)
ASP  A  95 ( 0.6A)
ILE  A 135 ( 0.7A)
 1.12A 1nt2A-1rynA:
undetectable		 1nt2A-1rynA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1ryn PROTEIN CRS2
(Zea
mays) 		4 / 7 LEU A 124
VAL A 120
GLY A  72
VAL A  62
 LEU  A 124 ( 0.6A)
VAL  A 120 ( 0.6A)
GLY  A  72 ( 0.0A)
VAL  A  62 ( 0.5A)
 0.91A 1t88A-1rynA:
0.0		 1t88A-1rynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 11 GLY A  11
SER A  66
ILE A  75
ALA A  79
VAL A  62
 GLY  A  11 ( 0.0A)
SER  A  66 ( 0.0A)
ILE  A  75 ( 0.7A)
ALA  A  79 ( 0.0A)
VAL  A  62 ( 0.5A)
 1.09A 2nnhA-1rynA:
undetectable		 2nnhA-1rynA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 12 ILE A  38
LEU A  90
LEU A 176
VAL A 173
ILE A  54
 ILE  A  38 ( 0.6A)
LEU  A  90 ( 0.6A)
LEU  A 176 ( 0.6A)
VAL  A 173 ( 0.6A)
ILE  A  54 ( 0.7A)
 1.30A 3adsB-1rynA:
undetectable		 3adsB-1rynA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		4 / 8 HIS A  22
GLY A  11
ASN A  23
TYR A  17
 HIS  A  22 ( 1.0A)
GLY  A  11 ( 0.0A)
ASN  A  23 ( 0.6A)
TYR  A  17 ( 1.3A)
 1.40A 3ccfA-1rynA:
undetectable		 3ccfA-1rynA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 GLN A  44
PHE A  45
TYR A  82
 GLN  A  44 ( 0.6A)
PHE  A  45 ( 1.3A)
TYR  A  82 ( 1.3A)
 0.97A 3ucjB-1rynA:
undetectable		 3ucjB-1rynA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 GLN A  44
PHE A  45
TYR A  82
 GLN  A  44 ( 0.6A)
PHE  A  45 ( 1.3A)
TYR  A  82 ( 1.3A)
 0.97A 3ucjA-1rynA:
undetectable		 3ucjA-1rynA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 8 GLY A  52
GLY A  55
GLU A  36
LEU A 178
VAL A 177
 GLY  A  52 ( 0.0A)
GLY  A  55 ( 0.0A)
GLU  A  36 ( 0.5A)
LEU  A 178 ( 0.6A)
VAL  A 177 ( 0.5A)
 1.38A 4fgzA-1rynA:
undetectable		 4fgzA-1rynA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 PRO A  99
LEU A  98
GLN A 192
 PRO  A  99 ( 1.1A)
LEU  A  98 ( 0.5A)
GLN  A 192 ( 0.6A)
 0.53A 4pevB-1rynA:
5.0		 4pevB-1rynA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		4 / 5 GLY A 138
ARG A  21
GLU A 158
PHE A 154
 GLY  A 138 ( 0.0A)
ARG  A  21 ( 0.6A)
GLU  A 158 ( 0.6A)
PHE  A 154 ( 1.3A)
 1.02A 4r82A-1rynA:
undetectable
4r82B-1rynA:
undetectable		 4r82A-1rynA:
24.19
4r82B-1rynA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 SER A  97
ASP A 163
ASP A  94
 SER  A  97 ( 0.0A)
ASP  A 163 ( 0.6A)
ASP  A  94 ( 0.6A)
 0.78A 4uckA-1rynA:
undetectable		 4uckA-1rynA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ryn PROTEIN CRS2
(Zea
mays) 		4 / 5 ILE A  32
LEU A  60
HIS A  88
VAL A 177
 ILE  A  32 ( 0.6A)
LEU  A  60 ( 0.6A)
HIS  A  88 ( 1.0A)
VAL  A 177 ( 0.5A)
 1.24A 5jmnB-1rynA:
undetectable		 5jmnB-1rynA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ryn PROTEIN CRS2
(Zea
mays) 		5 / 11 LEU A 105
PRO A 131
LEU A 133
THR A 175
ALA A 172
 LEU  A 105 ( 0.6A)
PRO  A 131 ( 1.1A)
LEU  A 133 ( 0.6A)
THR  A 175 ( 0.8A)
ALA  A 172 ( 0.0A)
 1.06A 5o96A-1rynA:
undetectable
5o96B-1rynA:
2.1		 5o96A-1rynA:
22.13
5o96B-1rynA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.62A 5oexA-1rynA:
undetectable		 5oexA-1rynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.65A 5oexB-1rynA:
undetectable		 5oexB-1rynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.64A 5oexC-1rynA:
undetectable		 5oexC-1rynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.65A 5oexD-1rynA:
undetectable		 5oexD-1rynA:
19.03