SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ryo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 6 HIS A 249
LYS A  78
ALA A 253
VAL A 305
 FE  A 329 ( 3.3A)
None
None
None
 1.01A 1hk1A-1ryoA:
undetectable		 1hk1A-1ryoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 6 LEU A 134
VAL A  67
VAL A 246
ILE A 323
 None
 1.14A 2hyyB-1ryoA:
undetectable		 2hyyB-1ryoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 GLU A  13
GLN A  20
ARG A  23
 None
 0.77A 2w3bB-1ryoA:
undetectable		 2w3bB-1ryoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 TYR A 319
TYR A  95
GLY A  65
 None
FE  A 329 ( 4.4A)
None
 0.70A 3eteB-1ryoA:
undetectable
3eteD-1ryoA:
undetectable
3eteF-1ryoA:
undetectable		 3eteB-1ryoA:
23.24
3eteD-1ryoA:
23.24
3eteF-1ryoA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 6 LEU A 134
VAL A  67
VAL A 246
ILE A 323
 None
 1.14A 3k5vA-1ryoA:
undetectable		 3k5vA-1ryoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 6 LEU A 134
VAL A  67
VAL A 246
ILE A 323
 None
 1.17A 3k5vB-1ryoA:
undetectable		 3k5vB-1ryoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 TYR A 223
GLU A 212
TYR A 188
 None
None
OXL  A 328 ( 3.7A)
 1.02A 3ug8A-1ryoA:
undetectable		 3ug8A-1ryoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		5 / 12 LEU A 226
LEU A 112
PHE A 204
ALA A  97
SER A 105
 None
 1.33A 4aqlA-1ryoA:
undetectable		 4aqlA-1ryoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 6 GLY A 258
ASN A  55
GLU A 260
ILE A 263
 None
 0.87A 4fglD-1ryoA:
undetectable		 4fglD-1ryoA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 PRO A 247
TYR A 314
GLY A 316
 None
 0.49A 4g2zA-1ryoA:
42.1		 4g2zA-1ryoA:
42.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		6 / 7 ILE A 130
LEU A 134
HIS A 242
ALA A 244
TYR A 319
ALA A 322
 None
 0.58A 4g77A-1ryoA:
41.8		 4g77A-1ryoA:
42.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 8 PHE A 153
VAL A 202
ASP A 201
ALA A  99
 None
 0.88A 4m48A-1ryoA:
undetectable		 4m48A-1ryoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 SER A 125
ASP A  47
ASP A  69
 OXL  A 328 ( 4.6A)
None
None
 0.73A 4uckA-1ryoA:
undetectable		 4uckA-1ryoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 5 LEU A  66
ALA A  64
LEU A  62
VAL A 246
 None
 1.18A 5cr1A-1ryoA:
undetectable		 5cr1A-1ryoA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 GLY A  34
GLN A 269
LYS A   4
 None
 0.94A 5imsB-1ryoA:
undetectable		 5imsB-1ryoA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		4 / 6 ASP A 138
ASN A 230
LEU A 226
PHE A 204
 None
 1.10A 6ekuA-1ryoA:
0.0		 6ekuA-1ryoA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 LEU A  72
ASN A 129
LEU A 315
 None
 0.57A 6exiD-1ryoA:
undetectable		 6exiD-1ryoA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ryo SEROTRANSFERRIN
(Homo
sapiens) 		3 / 3 ASP A  63
LEU A  66
ARG A 327
 FE  A 329 ( 3.2A)
None
None
 0.59A 7dfrA-1ryoA:
undetectable		 7dfrA-1ryoA:
20.66