SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_B_VIBB504_1 (YKOF)	1rz3	HYPOTHETICAL PROTEIN RBSTP0775 (Geobacillus stearothermophil us)	4 / 6	HIS A 57 LEU A 38 ILE A 27 SER A 33	None	1.17A	1sbrA-1rz3A: 0.0 1sbrB-1rz3A: 0.0	1sbrA-1rz3A: 24.43 1sbrB-1rz3A: 24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JSE_A_H4BA804_1 (NITRIC OXIDE SYNTHASE, BRAIN)	1rz3	HYPOTHETICAL PROTEIN RBSTP0775 (Geobacillus stearothermophil us)	4 / 7	MET A 58 ARG A 137 PHE A 144 GLU A 131	None	1.29A	4jseA-1rz3A: 0.0 4jseB-1rz3A: 0.0	4jseA-1rz3A: 19.56 4jseB-1rz3A: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MJ8_C_SPMC201_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	1rz3	HYPOTHETICAL PROTEIN RBSTP0775 (Geobacillus stearothermophil us)	4 / 7	ASN A 73 GLU A 74 GLU A 75 TYR A 69	None	1.37A	4mj8C-1rz3A: undetectable	4mj8C-1rz3A: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1rz3	HYPOTHETICAL PROTEIN RBSTP0775 (Geobacillus stearothermophil us)	4 / 4	GLY A 50 LEU A 25 PHE A 146 ILE A 14	None	0.95A	4xv2A-1rz3A: undetectable	4xv2A-1rz3A: 21.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SBR_B_VIBB504_1","YKOF;YKOF","1rz3","HYPOTHETICAL PROTEIN RBSTP0775","Geobacillus stearothermophilus",4,"HIS A  57;LEU A  38;ILE A  27;SER A  33","None","1.17A","1sbrA-1rz3A:0.0;1sbrB-1rz3A:0.0","1sbrA-1rz3A:24.43;1sbrB-1rz3A:24.43"],["4JSE_A_H4BA804_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","1rz3","HYPOTHETICAL PROTEIN RBSTP0775","Geobacillus stearothermophilus",4,"MET A  58;ARG A 137;PHE A 144;GLU A 131","None","1.29A","4jseA-1rz3A:0.0;4jseB-1rz3A:0.0","4jseA-1rz3A:19.56;4jseB-1rz3A:19.56"],["4MJ8_C_SPMC201_1","SPERMIDINE N1-ACETYLTRANSFERASE","1rz3","HYPOTHETICAL PROTEIN RBSTP0775","Geobacillus stearothermophilus",4,"ASN A  73;GLU A  74;GLU A  75;TYR A  69","None","1.37A","4mj8C-1rz3A:undetectable","4mj8C-1rz3A:21.26"],["4XV2_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1rz3","HYPOTHETICAL PROTEIN RBSTP0775","Geobacillus stearothermophilus",4,"GLY A  50;LEU A  25;PHE A 146;ILE A  14","None","0.95A","4xv2A-1rz3A:undetectable","4xv2A-1rz3A:21.21"]]